Carbon Nanotube- and Asbestos-Induced DNA and RNA Methylation Changes in Bronchial Epithelial Cells

Emerce, Esra; Ghosh, Manosij; Öner, Deniz; Duca, Radu Corneliu; Vanoirbeek, Jeroen; Bekaert, Bram; Hoet, Peter; Godderis, Lode

doi:10.1021/acs.chemrestox.8b00406

Cited by 32 publications

(25 citation statements)

References 85 publications

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“…A further study estimated the carcinogenic effects of CNTs: the study was conducted for 15 days, and results highlighted an increase in the tumor rate (bronchial alveolar adenoma and adenocarcinoma) and suggests CNTs as promoters of carcinogenesis [22]. However, although researchers have compared some forms of CNTs to other hazardous fibrous materials, such as asbestos [20,23], the possible health effects associated with CNT exposure are still to be defined. A particular MWCNT (Mitsui-7) was classified as "possibly carcinogenic to humans" (Group 2B), while for other CNTs, insufficient data are available for classification [8,24].…”

Section: Hazard Identificationmentioning

confidence: 99%

Carbon Nanotubes: Probabilistic Approach for Occupational Risk Assessment

et al. 2021

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In this study, the occupational risk assessment of carbon nanotubes (CNTs) was performed by means of a probabilistic approach. Chronic and subchronic inhalation exposure studies were retrieved during the hazard identification phase of the study. These studies were then used to obtain a guidance value (BMCh, expressed as a lognormal distribution with geometric mean ± geometric standard deviation = 10.0 ± 4.2 µg/m3) for occupational inhalation exposure to CNTs. An exposure scenario was selected from the scientific literature: three different work events (WEs) related to the production of conductive films were considered: (WE1) manufacturing of single walled carbon nanotubes films during normal operation using local exhaust ventilation (LEV); (WE2) manufacturing of SWCNT film without LEV; and (WE3) cleaning of one of the reactors. For each WE, a probability distribution function was applied, considering exposure expressed as mass concentration, as derived from three different measurement techniques. The ratio of the exposure and the BMCh distributions (i.e., the risk characterization ratio—RCR) was used to calculate the probability of occurrence of a relevant occupational risk. All the considered WEs indicated the presence of a risk (i.e., RCR distributions ≥ 1); however, only WE2 resulted in a statistically significant level of risk.

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Section: Hazard Identificationmentioning

confidence: 99%

Carbon Nanotubes: Probabilistic Approach for Occupational Risk Assessment

et al. 2021

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“…In fact, most of the nanoparticles are insoluble by nature and, at the same time, they can be dispersed and remain stable within a solution [41]. So, the health and safety concerns about the different types of carbon nanoparticles have been addressed for almost two decades, however consensus on this topic is still far from being reached [5,42].…”

Section: Healthmentioning

confidence: 99%

Health and Safety Concerns Related to CNT and Graphene Products, and Related Composites

et al. 2020

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The use of Carbon Nanotubes (CNT) and Graphene increased in the last decade and it is likely to keep increasing in the near future. The attractiveness of their properties, particularly the possibility to enhance the composites performance using a tailor made methodology, brings new materials, processes and products for highly demanding industrial applications and to the market. However, there are quite a lot of health/safety issues, as well as lack of understanding and standards to evaluate their effects. This paper starts with a general description of materials, processes and products dealing with CNT and graphene. Then, an overview of concerns related to the health and safety when handling, researching, producing and using products that include these materials is presented. It follows a risk management approach with respect to simulation and evaluation tools, and considering the consensual limits already existing for research, industry and consumers. A general discussion integrating the relevant aspects of health and safety with respect to CNT and graphene is also presented. A proactive view is presented with the intention to contribute with some guidelines on installation, maintenance, evaluation, personal protection equipment (PPE) and personnel training to deal with these carbon-based nanomaterials in research, manufacture, and use with composite materials.

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“…In the present days, CNTs are extensively used in different industries, such as electronic industry, nanomedicine for efficient drug delivery, biochemical sensors, and diagnostic supplies production. CNTs, including their single‐layered and multilayered products are well‐known carbon nanomaterials applied for various nanotechnological benefits (Chatterjee, Yang, Kim, Woo, & Choi, 2016; Emerce et al, 2019). Environmental agents are contributing factors for epigenetic changes, a persuasive signature of carcinoma (Pogribny & Beland, 2009).…”

Section: Epigenetic Changes Link Ecs To Adverse Health Outcomesmentioning

confidence: 99%

“…The epigenetic silencing of MAP kinases, ATM and PIK3R2 genes, may lead to tumorigenesis or carcinoma (Ai et al, 2004). Interestingly, Emerce et al (2019) uncovered that MWCNTs exposure in 16HBE cells caused RNA modifications in addition to genomic DNA methylation. MWCNTs can hypomethylate RNA (m6A‐RNA) at the base adenine.…”

Section: Epigenetic Changes Link Ecs To Adverse Health Outcomesmentioning

confidence: 99%

Linking emerging contaminants exposure to adverse health effects: Crosstalk between epigenome and environment

Alam

Shapla

Shen

et al. 2020

J of Applied Toxicology

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Environmental epigenetic findings shed new light on the roles of epigenetic regulations in environmental exposure‐induced toxicities or disease susceptibilities. Currently, environmental emerging contaminants (ECs) are in focus for further investigation due to the evidence of human exposure in addition to their environmental occurrences. However, the adverse effects of these environmental ECs on health through epigenetic mechanisms are still poorly addressed in many aspects. This review discusses the epigenetic mechanisms (DNA methylation, histone modifications, and microRNA expressions) linking ECs exposure to health outcomes. We emphasized on the recent literature describing how ECs can dysregulate epigenetic mechanisms and lead to downstream health outcomes. These up‐to‐date research outputs could provide novel insights into the toxicological mechanisms of ECs. However, the field still faces a demand for further studies on the broad spectrum of health effects, synergistic/antagonistic effects, transgenerational epigenetic effects, and epidemiologic and demographic data of ECs.

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Carbon Nanotube- and Asbestos-Induced DNA and RNA Methylation Changes in Bronchial Epithelial Cells

Cited by 32 publications

References 85 publications

Carbon Nanotubes: Probabilistic Approach for Occupational Risk Assessment

Carbon Nanotubes: Probabilistic Approach for Occupational Risk Assessment

Health and Safety Concerns Related to CNT and Graphene Products, and Related Composites

Linking emerging contaminants exposure to adverse health effects: Crosstalk between epigenome and environment

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