Carbon Nanoparticles Based Electrochemical Biosensor Strip for Detection of Japanese Encephalitis Virus

Lai, Huat Choi; Chin, Suk Fun; Pang, Suh Cem; Sum, Magdline Sia Henry; Perera, David

doi:10.1155/2017/3615707

Cited by 35 publications

(29 citation statements)

References 21 publications

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“…Which improves electron transfer efficiency. In addition, the amino group on the surface of CNPs enable the attachment of antibody ( Lai et al, 2017 ). Later, AgNPs was used to modify SPCE, and investigated by EIS analysis concerning JEV.…”

Section: Electrochemical Biosensors For Virus Detectionmentioning

confidence: 99%

Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art

Khan¹,

Hasan

Hossain

et al. 2020

Biosensors and Bioelectronics

164

108

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Last few decades, viruses are a real menace to human safety. Therefore, the rapid identification of viruses should be one of the best ways to prevent an outbreak and important implications for medical healthcare. The recent outbreak of coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus which belongs to the single-stranded, positive-strand RNA viruses. The pandemic dimension spread of COVID-19 poses a severe threat to the health and lives of seven billion people worldwide. There is a growing urgency worldwide to establish a point-of-care device for the rapid detection of COVID-19 to prevent subsequent secondary spread. Therefore, the need for sensitive, selective, and rapid diagnostic devices plays a vital role in selecting appropriate treatments and to prevent the epidemics. During the last decade, electrochemical biosensors have emerged as reliable analytical devices and represent a new promising tool for the detection of different pathogenic viruses. This review summarizes the state of the art of different virus detection with currently available electrochemical detection methods. Moreover, this review discusses different fabrication techniques, detection principles, and applications of various virus biosensors. Future research also looks at the use of electrochemical biosensors regarding a potential detection kit for the rapid identification of the COVID-19.

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Section: Electrochemical Biosensors For Virus Detectionmentioning

confidence: 99%

Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art

Khan¹,

Hasan

Hossain

et al. 2020

Biosensors and Bioelectronics

164

108

View full text Add to dashboard Cite

show abstract

“…The majority of publications are devoted to registration of the resultant current of the redox probe corresponding to changing electrode potential. Ferri/ferrocyanide, ferrocene, ferrocenethanol systems, and ruthenium complexes are the most frequently used redox probes [50,69,70]. The electrochemical behavior of redox probes depends on the receptor layer and the biosensor operating principle.…”

Section: Voltammetry Amperometrymentioning

confidence: 99%

“…Chin and co-workers successfully applied CNPs for conjugation with JEV antibody and detection of JEV in human serum samples on a SPCE, with LOD of 2 ng/mL [121]. Another research group also modified a SPCE by CNPs for rapid and sensitive detection of JEV in human serum, with an LOD of 0.36 ng/mL [70]. Figure 6 depicts the preparation of the electrochemical biosensor for the detection of JEV with using CNPs as an immobilization platform for the JEV antibody [70].…”

Section: Electrochemical Biosensors For Jev Diagnosticmentioning

confidence: 99%

Label-Free Electrochemical Biosensors for the Determination of Flaviviruses: Dengue, Zika, and Japanese Encephalitis

Khristunova

Dorozhko

Короткова

et al. 2020

Sensors

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A highly effective way to improve prognosis of viral infectious diseases and to determine the outcome of infection is early, fast, simple, and efficient diagnosis of viral pathogens in biological fluids. Among a wide range of viral pathogens, Flaviviruses attract a special attention. Flavivirus genus includes more than 70 viruses, the most familiar being dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV). Haemorrhagic and encephalitis diseases are the most common severe consequences of flaviviral infection. Currently, increasing attention is being paid to the development of electrochemical immunological methods for the determination of Flaviviruses. This review critically compares and evaluates recent research progress in electrochemical biosensing of DENV, ZIKV, and JEV without labelling. Specific attention is paid to comparison of detection strategies, electrode materials, and analytical characteristics. The potential of so far developed biosensors is discussed together with an outlook for further development in this field.

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“…They showed that the smartphone reader had a hardware which connected to the back of a smartphone and provided the user with an interface to handle the operation, communicate with cloud services and acquire test results, and also developed a safe cloud service for the tele-monitoring of results (Natesan et al, 2019). Carbon-NPs-modified screen-printed carbon electrode (SPCE)-based electrochemical biosensor strip for rapid and sensitive detection of the Japanese Encephalitis Virus (JEV) was developed by Lai et al (2017). Hamdy et al (2018) developed an ultrasensitive AuNPs biosensor functionalized with thiol-linked oligonucleotides, which could recognize conserved RNA standards of foot and mouth disease virus (FMDV).…”

Section: Nanotechnology-based Techniquesmentioning

confidence: 99%

Emerging Molecular Prospective of SARS-CoV-2: Feasible Nanotechnology Based Detection and Inhibition

et al. 2020

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The rapid dissemination of SARS-CoV-2 demonstrates how vulnerable it can make communities and is why it has attained the status of global pandemic. According to the estimation from Worldometer, the SARS-CoV-2 affected cases and deaths are exponentially increasing worldwide, marking the mortality rate as ∼3.8% with no probability of its cessation till now. Despite massive attempts and races among scientific communities in search of proper therapeutic options, the termination of this breakneck outbreak of COVID-19 has still not been made possible. Therefore, this review highlights the diverse molecular events induced by a viral infection, such as autophagy, unfolded protein response (UPR), and inflammasome, illustrating the intracellular cascades regulating viral replication inside the host cell. The SARS-CoV-2-mediated endoplasmic reticulum stress and apoptosis are also emphasized in the review. Additionally, host's immune response associated with SARS-CoV-2 infection, as well as the genetic and epigenetic changes, have been demonstrated, which altogether impart a better understanding of its epidemiology. Considering the drawbacks of available diagnostics and medications, herein we have presented the most sensitive nano-based biosensors for the rapid detection of viral components. Moreover, conceptualizing the viral-induced molecular changes inside its target cells, nano-based antiviral systems have also been proposed in this review.

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Carbon Nanoparticles Based Electrochemical Biosensor Strip for Detection of Japanese Encephalitis Virus

Cited by 35 publications

References 21 publications

Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art

Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art

Label-Free Electrochemical Biosensors for the Determination of Flaviviruses: Dengue, Zika, and Japanese Encephalitis

Emerging Molecular Prospective of SARS-CoV-2: Feasible Nanotechnology Based Detection and Inhibition

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