Carbon nanoparticles as possible radioprotectors in biological systems

Krokosz, Anita; Lichota, Anna; Nowak, Katarzyna; Grebowski, Jacek

doi:10.1016/j.radphyschem.2016.07.006

Cited by 39 publications

(22 citation statements)

References 61 publications

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“…Several review articles, including ours, have summarized the recent progress. [ 20,24–27 ] Despite great achievements made in the use of nanomedicines for radioprotection, the research undertaken by the biomaterials research community in the past decades has been primarily focused on some common issues, such as the synthesis of nanomaterials with novel structures and functions, the characterization of nanomaterials, and the discovery of new applications. Some fundamental but key questions, such as the rational design principle for radioprotection, are held in low regard.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

Xie

Zhao

Wang

et al. 2021

Adv Healthcare Materials

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Radiation treatments often unfavorably damage neighboring healthy organs and cause a series of radiation sequelae, such as radiation‐induced hematopoietic system diseases, radiation‐induced gastrointestinal diseases, radiation‐induced lung diseases, and radiation‐induced skin diseases. Recently, emerging nanomaterials have exhibited good superiority for these radiation‐induced disease treatments. Given this background, the rational design principle of nanomaterials, which helps to optimize the therapeutic efficiency, has been an increasing need. Consequently, it is of great significance to perform a systematic summarization of the advances in this field, which can trigger the development of new high‐performance nanoradioprotectors with drug efficiency maximization. Herein, this review highlights the advances and perspectives in the rational design of nanomaterials for preventing and treating various common radiation‐induced diseases. Furthermore, the sources, clinical symptoms, and pathogenesis/injury mechanisms of these radiation‐induced diseases will also be introduced. Furthermore, current challenges and directions for future efforts in this field are also discussed.

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Section: Introductionmentioning

confidence: 99%

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

Xie

Zhao

Wang

et al. 2021

Adv Healthcare Materials

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“…Nanotechnology isthe treatment and production of materials on the size of atoms and has possible applications in a wide range of sectors, from energy, materials electronics, optics, and remediation, to food, cosmetics, and medicine (Jeevanandam et al, 2018).The natural radiomitigators in nano form are achieving better stability, lower toxicity, and better penetration and distribution into the tissue (Krokosz et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

et al. 2021

Preprint

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Zinc Coumarate and zinc caffeiatenano-particles (ZCoNPs, ZCaNPs) have been shown to affectthe different biological processes. This work was undertaken to evaluate the mitigating action of ZCoNPs in combination with ZCaNPsagainst liver damage induced by gamma rays (γ-rays). Rats were exposed to 7Gy of γ-rays, and theninjected intraperitoneally (i.p.) with ZCoNPs [2U / rat / day (5 mg/kg)], and ZCaNPs [2U / rat / day (15 mg/kg)] for 7 consecutive days.The results showed that irradiated rats treated with ZCoNPs (5 mg/kg/body weight) in combination with ZCaNPs (15 mg/kg/body weight) for 7 days revealed a significant increase in the body weight, antioxidants levels, T Helper (CD4) Cell and T Cytotoxic (CD8), associated with amarked decrease in the level of lipid peroxidation (LP), nitric oxide(NOx), total free radicals concentrate (TFRC), and DNA fragmentation. Moreover, positive alterations in the morphological state, hematological parameters, and thecell cycle phases were noticed. Additionally, the histopathological study demonstrated an improvement in the liver tissue of irradiated rats after treatment.Thus, ZCoNPs and ZCaNPscould be usedas a natural mitigating agent to reduce the hazards of ionizing radiation.

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“…Researchers have discovered that some carbon nanomaterials such as fullerene, [ 11 ] carbon nanotube, [ 12 ] and graphdiyne [ 13 ] show good free radical scavenging ability, even stronger than traditional molecule drugs. [ 14 ] In addition, these carbon nanomaterials have relatively longer systematic circulation in the body and better chemical stability in different physiological environments than those molecule drugs, and thus show a great potential to alleviate the radiotoxicity of the intestine via oral administration. Although these nanomaterials display efficient radioprotective performance, they still face various challenges in clinical transformation, including the construction of pharmacokinetic models, [ 15 ] the design of nanomedicines [ 16 ] and the evaluation of biological properties, [ 17 ] which make it difficult for clinical transformation.…”

Section: Introductionmentioning

confidence: 99%

Clinically Approved Carbon Nanoparticles with Oral Administration for Intestinal Radioprotection via Protecting the Small Intestinal Crypt Stem Cells and Maintaining the Balance of Intestinal Flora

Wang

Xie

Dong

et al. 2020

Small

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The exploration of an old drug for new biomedical applications has an absolute predominance in shortening the clinical conversion time of drugs for clinical application. In this work, carbon nanoparticles suspension injection (CNSI), the first clinically approved carbon nanoparticles in China, is explored as a new nano‐radioprotective agent for potent intestinal radioprotection. CNSI shows powerful radioprotective performance in the intestine under oral administration, including efficient free radical scavenging ability, good biosafety, high chemical stability, and relatively long retention time. For example, CNSI shows high reactive oxygen species (ROS) scavenging activities, which effectively alleviates the mitochondrial dysfunction and DNA double‐strand breaks to protect the cells against radiation‐induced damage. Most importantly, this efficient ROS scavenging ability greatly helps restrain the apoptosis of the small intestinal epithelial and crypt stem cells, which decreases the damage of the mechanical barrier and thus relieves radiation enteritis. Moreover, CNSI helps remove the free radicals in the intestinal microenvironment and thus maintain the balance of intestinal flora so as to mitigate the radiation enteritis. The finding suggests a new application of clinically approved carbon nanoparticles, which not only promotes the development of new intestinal radioprotector, but also has a great potential for clinical transformation.

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Carbon nanoparticles as possible radioprotectors in biological systems

Cited by 39 publications

References 61 publications

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

Clinically Approved Carbon Nanoparticles with Oral Administration for Intestinal Radioprotection via Protecting the Small Intestinal Crypt Stem Cells and Maintaining the Balance of Intestinal Flora

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