Carbon nanomaterials for phototherapy of cancer and microbial infections

Amaral, Sara I.; Costa‐Almeida, Raquel; Gonçalves, Inês C.; Magalhães, Fernão D.; Pinto, Artur M.

doi:10.1016/j.carbon.2021.12.084

Cited by 28 publications

(21 citation statements)

References 333 publications

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“…Systematic and thorough in vitro and in vivo testing, both short and long-term, are the first steps prior to human clinical trials. Bioaccumulation in the major organs or tissues, impurities/contamination, dosage, ROS generation, and particle size are some of the biggest concerns regarding the use of nano-scaled materials [ 125 , 126 , 127 , 128 ]. Graphene has been widely researched for biomedical applications and has demonstrated great properties for its use in cancer treatment, despite controversial results regarding its biosafety [ 126 , 129 ].…”

Section: 2d Nanomaterials Polymeric Composites For Biomedical Applica...mentioning

confidence: 99%

“…Bioaccumulation in the major organs or tissues, impurities/contamination, dosage, ROS generation, and particle size are some of the biggest concerns regarding the use of nano-scaled materials [ 125 , 126 , 127 , 128 ]. Graphene has been widely researched for biomedical applications and has demonstrated great properties for its use in cancer treatment, despite controversial results regarding its biosafety [ 126 , 129 ]. BP has been demonstrated to have higher biocompatibility than graphene, especially when incorporated in biopolymers or surface-functionalized [ 130 ].…”

Section: 2d Nanomaterials Polymeric Composites For Biomedical Applica...mentioning

confidence: 99%

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New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications

2022

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The constant evolution and advancement of the biomedical field requires robust and innovative research. Two-dimensional nanomaterials are an emerging class of materials that have risen the attention of the scientific community. Their unique properties, such as high surface-to-volume ratio, easy functionalization, photothermal conversion, among others, make them highly versatile for a plethora of applications ranging from energy storage, optoelectronics, to biomedical applications. Recent works have proven the efficiency of 2D nanomaterials for cancer photothermal therapy (PTT), drug delivery, tissue engineering, and biosensing. Combining these materials with hydrogels and scaffolds can enhance their biocompatibility and improve treatment for a variety of diseases/injuries. However, given that the use of two-dimensional nanomaterials-based polymeric composites for biomedical applications is a very recent subject, there is a lot of scattered information. Hence, this review gathers the most recent works employing these polymeric composites for biomedical applications, providing the reader with a general overview of their potential.

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Section: 2d Nanomaterials Polymeric Composites For Biomedical Applica...mentioning

confidence: 99%

Section: 2d Nanomaterials Polymeric Composites For Biomedical Applica...mentioning

confidence: 99%

New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications

2022

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“…Thus, immobilization on other materials has been proposed to decrease cellular internalization [25] . Graphene-based materials (GBM) are promising particles with larger sizes –hundreds to thousands of nanometers– for reduced internalization, showing good biocompatibility at high concentrations in vitro and in vivo , as well as biodegradation by neutrophils or the human enzyme myeloperoxidase [26,27] . In particular, reduced graphene oxide (rGO) is a popular GBM with greater hemocompatibility than graphene oxide [28,29] that has been shown to promote myogenic differentiation with low reduction in cell viability [13] .…”

Section: Introductionmentioning

confidence: 99%

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

Servin

Dahri

Meneses

et al. 2023

Preprint

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Tunable culture platforms that guide cellular organization and mechanically stimulate skeletal muscle development are still unavailable due to limitations in biocompatibility and actuation triggered without contact. This study reports the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting (MEW) of a thermoplastic/graphene/iron oxide composite. In situ deposition of iron oxide nanoparticles on oxidized graphene yielded homogeneously dispersed magnetic particles with sizes above 0.5 micrometer and low aspect ratio, preventing cellular internalization and toxicity. With these fillers, homogeneous magnetic composites with very high magnetic filler content (up to 10 wt.%) were obtained and successfully processed in a solvent-free manner for the first time. MEW of magnetic composites enabled the skeletal muscle-inspired design of hexagonal scaffolds with tunable fiber diameter, reconfigurable modularity, and zonal distribution of magneto-active and nonactive material. Importantly, the hexagonal microstructures displayed elastic deformability under tension, mitigating the mechanical limitations due to high filler content. External magnetic fields below 300 mT were sufficient to trigger out-of-plane reversible deformation leading to effective end-to-end length decrease up to 17%. Moreover, C2C12 myoblast culture on 3D Matrigel/collagen/MEW scaffolds showed that the presence of magnetic particles in the scaffolds did not significantly affect viability after 8 days with respect to scaffolds without magnetic filler. Importantly, in vitro culture demonstrated that myoblasts underwent differentiation at similar rates regardless of the presence of magnetic filler. Overall, these innovative microfiber scaffolds were proven as a magnetically deformable platform suitable for dynamic culture of skeletal muscle with potential for in vitro disease modeling.

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“…The clinical treatment of cancer still faces numerous problems associated with unsatisfactory treatment effectiveness and damage to healthy tissues. − Phototherapy is noninvasive, exhibits minimal side effects, and is highly selective and has been established as an excellent candidate for cancer treatment. − However, treatment efficacy is often unsatisfactory when phototherapy is used, due to limits imposed by the hypoxic tumor microenvironment (TME), including less O 2 that can decrease photodynamic efficacy and the up-regulated heat shock proteins (HSPs) may cause thermal resistance. − To overcome these obstacles, nanodrug combinations called “nanococktails” comprised of photosensitizers and multiple units for the relief of hypoxia and the down-regulation of HSPs have been fabricated and utilized for cancer therapy. However, their construction remains challenging due to the utility of multiple components, requiring multistep manufacturing and potential systemic toxicity. − …”

Section: Introductionmentioning

confidence: 99%

Nanococktail Based on Supramolecular Glyco-Assembly for Eradicating Tumors In Vivo

Feng

Zhang

Wan

et al. 2022

ACS Appl. Mater. Interfaces

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The development of robust phototherapeutic strategies for eradicating tumors remains a significant challenge in the transfer of cancer phototherapy to clinical practice. Here, a phototherapeutic nanococktail atovaquone/17-dimethylaminoethylamino-17-demethoxygeldanamycin/glyco-BODIPY (ADB) was developed to enhance photodynamic therapy (PDT) and photothermal therapy (PTT) via alleviation of hypoxia and thermal resistance that was constructed using supramolecular self-assembly of glyco-BODIPY (BODIPY-SS-LAC, BSL-1), hypoxia reliever atovaquone (ATO), and heat shock protein inhibitor 17dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG). Benefiting from a glyco-targeting and glutathione (GSH) responsive units BSL-1, ADB can be rapidly taken up by hepatoma cells, furthermore the loaded ATO and 17-DMAG can be released in original form into the cytoplasm. Using in vitro and in vivo results, it was confirmed that ADB enhanced the synergetic PDT and PTT upon irradiation using 685 nm near-infrared light (NIR) under a hypoxic tumor microenvironment where ATO can reduce O 2 consumption and 17-DMAG can down-regulate HSP90. Moreover, ADB exhibited good biosafety, and tumor eradication in vivo. Hence, this as-developed phototherapeutic nanococktail overcomes the substantial obstacles encountered by phototherapy in tumor treatment and offers a promising approach for the eradication of tumors.

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Carbon nanomaterials for phototherapy of cancer and microbial infections

Cited by 28 publications

References 333 publications

New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications

New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

Nanococktail Based on Supramolecular Glyco-Assembly for Eradicating Tumors In Vivo

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