Carbon nanomaterials and metallic nanoparticles-incorporated electrochemical sensors for small metabolites: Detection methodologies and applications

Si, Yunpei; Lee, Hye Jin

doi:10.1016/j.coelec.2020.08.007

Cited by 37 publications

(13 citation statements)

References 75 publications

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“…Small metabolites are considered as sensitive markers for disease diagnosis ( Wishart, 2016 ; Si and Lee, 2020 ). For example, the increase of dimethylarginine dimethylaminohydrolases (DDAHs) and inducible nitric oxide synthase (iNOS) could cause the up-regulation of nitric oxide (NO) expression in patients with IPF ( Dong et al, 2020 ).…”

Section: Imaging Of Pulmonary Fibrosis-related Biomarkersmentioning

confidence: 99%

Recent Advances in Fluorescence Imaging of Pulmonary Fibrosis in Animal Models

Liu

Tang

Zhu

et al. 2021

Front. Mol. Biosci.

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Pulmonary fibrosis (PF) is a lung disease that may cause impaired gas exchange and respiratory failure while being difficult to treat. Rapid, sensitive, and accurate detection of lung tissue and cell changes is essential for the effective diagnosis and treatment of PF. Currently, the commonly-used high-resolution computed tomography (HRCT) imaging has been challenging to distinguish early PF from other pathological processes in the lung structure. Magnetic resonance imaging (MRI) using hyperpolarized gases is hampered by the higher cost to become a routine diagnostic tool. As a result, the development of new PF imaging technologies may be a promising solution. Here, we summarize and discuss recent advances in fluorescence imaging as a talented optical technique for the diagnosis and evaluation of PF, including collagen imaging, oxidative stress, inflammation, and PF-related biomarkers. The design strategies of the probes for fluorescence imaging (including multimodal imaging) of PF are briefly described, which can provide new ideas for the future PF-related imaging research. It is hoped that this review will promote the translation of fluorescence imaging into a clinically usable assay in PF.

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Section: Imaging Of Pulmonary Fibrosis-related Biomarkersmentioning

confidence: 99%

Recent Advances in Fluorescence Imaging of Pulmonary Fibrosis in Animal Models

Liu

Tang

Zhu

et al. 2021

Front. Mol. Biosci.

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“…The main types of neurotransmitters are amino acids (e.g., glutamic acid), peptides (e.g., somatostatin), purine derivatives (e.g., ATP), and monoamines (e.g., dopamine) [ 16 ]. Amino acids metabolism is related to alkaline proteinuria, phenylketonuria and maple syrupuria [ 17 ], which are the components of proteins and precursors of neurotransmitters [ 18 ]. ATP is an important neurotransmitter that produces metabolites in the degradation process, including inosine (INO), hypoxanthine (HX) and uric acid (UA).…”

Section: Introductionmentioning

confidence: 99%

Human metabolite detection by surface-enhanced Raman spectroscopy

Liu

2022

Materials Today Bio

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Metabolites are important biomarkers in human body fluids, conveying direct information of cellular activities and physical conditions. Metabolite detection has long been a research hotspot in the field of biology and medicine. Surface-enhanced Raman spectroscopy (SERS), based on the molecular “fingerprint” of Raman spectrum and the enormous signal enhancement (down to a single-molecule level) by plasmonic nanomaterials, has proven to be a novel and powerful tool for metabolite detection. SERS provides favorable properties such as ultra-sensitive, label-free, rapid, specific, and non-destructive detection processes. In this review, we summarized the progress in recent 10 years on SERS-based sensing of endogenous metabolites at the cellular level, in tissues, and in biofluids, as well as drug metabolites in biofluids. We made detailed discussions on the challenges and optimization methods of SERS technique in metabolite detection. The combination of SERS with modern biomedical technology were also anticipated.

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“…Um aspecto importante na preparação de um EQM é a escolha do modificador [28]. Este material deve apresentar características eletroquímicas apropriadas e ser adequado para o método de modificação selecionado [29]. Entre os materiais convencionais estão: grafeno, metais, fulereno, nanotubos de carbono, pontos quânticos de carbono (CQDs), polímeros, estruturas metálicas orgânicas (MOFs) e compósitos [23].…”

Section: Eletrodos Quimicamente Modificadosunclassified

“…Nesse sentido, é importante selecionar a melhor técnica entre os diferentes procedimentos disponíveis para a fabricação e caracterização de eletrodos de modo a obter melhores resultados de análise. A escolha de uma abordagem depende de diversos fatores, dentre os quais das possibilidades econômicas, requisitos analíticos, tipo de eletrodo e natureza do modificador [29].…”

Section: Eletrodos Quimicamente Modificadosunclassified

“…[22][23][24] Among them, nickel-based electrocatalysts such as Ni, NiO 2 and Ni(OH) 2 micro and NPs have been extensively explored for modification of electrodes given their low prices and high electrocatalytic activity for many types of analytes. [25][26][27][28] These nanomaterials present great chemical stability, [29,30] as well as outstanding merits such as facile synthesis, excellent electrical conductivity, compatibility with water and organic solvents, large surface area, and high density of electrochemically active metallic sites on the surface, [23,24] as expected for their small particle size and relatively open layered structure.…”

Section: Introductionmentioning

confidence: 99%

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Desenvolvimento de (bio)sensores (nano)estruturados visando a determinação de analitos em amostras farmacêuticas e fluidos biológicos

Azeredo¹

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Carbon nanomaterials and metallic nanoparticles-incorporated electrochemical sensors for small metabolites: Detection methodologies and applications

Cited by 37 publications

References 75 publications

Recent Advances in Fluorescence Imaging of Pulmonary Fibrosis in Animal Models

Recent Advances in Fluorescence Imaging of Pulmonary Fibrosis in Animal Models

Human metabolite detection by surface-enhanced Raman spectroscopy

Desenvolvimento de (bio)sensores (nano)estruturados visando a determinação de analitos em amostras farmacêuticas e fluidos biológicos

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