Carbon nanofiber-PEDOT composite films as novel microelectrode for neural interfaces and biosensing

Saunier, Valentin; Flahaut, Emmanuel; Blatché, Marie-Charline; Bergaud, Christian; Maziz, Ali

doi:10.1016/j.bios.2020.112413

Cited by 60 publications

(64 citation statements)

References 60 publications

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“…The PEDOT:PSS/MWCNT composite not only possessed a high mechanical strength but also a high conductivity (323 ± 75 S m −1 ) facilitating a low impedance at a frequency of 1 kHz and thus a high S/N ratio of 24 for recording cardiomyocyte-like HL-1 cells. [85] Other works reported the doping of PEDOT during the electrochemical deposition with other materials such as dopamine [56,80] and carbon nanotubes [86] with the aim to decrease the impedance of the electrodes, as well.…”

Section: Multi-or Microelectrodes: Recording and Stimulationmentioning

confidence: 99%

PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals

Liang

Offenhäusser

Ingebrandt

et al. 2021

Adv Healthcare Materials

115

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To understand the physiology and pathology of electrogenic cells and the corresponding tissue in their full complexity, the quantitative investigation of the transmission of ions as well as the release of chemical signals is important. Organic (semi-) conducting materials and in particular organic electrochemical transistor are gaining in importance for the investigation of electrophysiological and recently biochemical signals due to their synthetic nature and thus chemical diversity and modifiability, their biocompatible and compliant properties, as well as their mixed electronic and ionic conductivity featuring ion-to-electron conversion. Here, the aim is to summarize recent progress on the development of bioelectronic devices utilizing polymer polyethylenedioxythiophene: poly(styrene sulfonate) (PEDOT:PSS) to interface electronics and biological matter including microelectrode arrays, neural cuff electrodes, organic electrochemical transistors, PEDOT:PSS-based biosensors, and organic electronic ion pumps. Finally, progress in the material development is summarized for the improvement of polymer conductivity, stretchability, higher transistor transconductance, or to extend their field of application such as cation sensing or metabolite recognition. This survey of recent trends in PEDOT:PSS electrophysiological sensors highlights the potential of this multifunctional material to revolve current technology and to enable long-lasting, multichannel polymer probes for simultaneous recordings of electrophysiological and biochemical signals from electrogenic cells.

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Section: Multi-or Microelectrodes: Recording and Stimulationmentioning

confidence: 99%

PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals

Liang

Offenhäusser

Ingebrandt

et al. 2021

Adv Healthcare Materials

115

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“…Non-conventional conducting materials that were not initially developed for neural implants have been receiving much attention and applied for neurophysiological recording in recent years because of their favorable properties and manufacturing advantages. Examples of these emerging electrode materials include graphene (Park et al, 2016;Kostarelos et al, 2017), indium tin oxide (ITO) (Aydin and Sezgintürk, 2017), carbon-polymer hybrid nanostructures (Guo et al, 2017;Saunier et al, 2020). In the search for suitable packaging and substrate materials, various types of glass and ceramic materials, such as alumina (Shen and Maharbiz, 2019), silicon nitride (Zhao et al, 2019), silicon carbide (SiC) (Lei et al, 2016), and silica (Cheng et al, 2013b), have greatly expanded the options for researchers.…”

Section: Introductionmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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“…In principle, the specific capacitance of an electrode may be greatly enhanced by introducing porous and high surface area organic materials into the electrode, thus compensating for a reduction of electrode size. Among the various organic materials reported in literature available to meet such requirements, conductive polymers such as Poly (3,4-ethylenedioxythiophene) (PEDOT) has a been popular choice that allow direct delivery of electrical, electrochemical and electromechanical signals at the electrode-tissue interface [1 , 6 , 17] . PEDOT-coated electrodes have been considered for biomedical [18] and bioelectronic applications [2 , 10 , 11 , 13] as well as in the fabrication of devices for neuronal interfaces [1 , 7] and electrochemical sensing and actuating devices [8 , 12 , 16] .…”

Section: Methods Detailsmentioning

confidence: 99%

“…Electrochemical detection of dopamine (DA) was performed by chronoamperometry at 130 mV vs SCE after this potential was identified previously as the oxidation potential of DA on PEDOT:CNF by CV [17] . The DA direct current responses ( N = 3) resulted in calibration plot i.e .…”

Section: Methods Validationmentioning

confidence: 99%

Microelectrodes from PEDOT-carbon nanofiber composite for high performance neural recording, stimulation and neurochemical sensing

et al. 2020

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This present method describes a versatile approach for the electrochemical synthesis of a composite material of Poly (3,4-ethylenedioxythiophene) (PEDOT) and Carbon Nanofibers (CNFs) for neural interfaces and biosensing applications. Oxidized CNFs were utilized as dopants of PEDOT to prepare the composite coating through electrochemical deposition on microelectrodes arrays (MEA). The experimental results of this study showed that PEDOT:CNF microelectrodes exhibit remarkable electrochemical properties, combining low impedance, high surface area, high charge injection capability and reliable neurotransmitters monitoring using amperometric techniques. Taken together, these results suggest the great potential of PEDOT:CNF composite for developing next-generation multifunctional microelectrodes for applications in neural therapies. A simple approach for the electrochemical synthesis of PEDOT:CNF composite material on microelectrodes for neural interfaces and neurochemical sensing. PEDOT:CNF microelectrodes exhibit remarkable electrochemical properties, combining low impedance and high charge injection capabilities. PEDOT:CNF microelectrodes allowed the reliable detection of neurotransmitters with improved sensitivity.

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Carbon nanofiber-PEDOT composite films as novel microelectrode for neural interfaces and biosensing

Cited by 60 publications

References 60 publications

PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals

PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Microelectrodes from PEDOT-carbon nanofiber composite for high performance neural recording, stimulation and neurochemical sensing

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