Carbon nanocoatings: A new approach to recording mass spectra of low-molecular compounds using surface-assisted laser desorption/ionization mass spectrometry

Kosyakov, D. S.; Sorokina, E. A.; Ul’yanovskii, N. V.; Varakin, E. A.; Чухчин, Д. Г.; Горбова, Н. С.

doi:10.1134/s1061934816130086

Cited by 8 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The method replaces the matrix by specifically adapted nanotextured materials such as silicon or various metal surfaces in order to assist the ionization process. − It is particularly suitable for small molecules such as amino acids and sugars that by themselves show little UV absorption in the range of commonly utilized MALDI lasers (330–360 nm). With respect to opiates, one report describes the use of carbon nanocoatings for inducing LDI of papaverine, while morphine and codeine were analyzed using silicon or clathrates. , Present results however have shown that opiates do sufficiently ionize upon simple laser irradiation and can be detected in crude poppy extracts without the support of any nanotextured material or surface. The SALDI approach may nevertheless be very useful for their detection in trace amounts …”

Section: Resultsmentioning

confidence: 91%

Matrix-Free Laser Desorption Ionization Mass Spectrometry as an Efficient Tool for the Rapid Detection of Opiates in Crude Extracts of Papaver somniferum

Skopikova

Hashimoto

Richomme

et al. 2019

J. Agric. Food Chem.

View full text Add to dashboard Cite

Having a long history of traditional medicinal applications, Papaver somniferum is also known as a source of various pharmacologically highly active opiates. Consequently, their detection from plant extracts is an important analytical task and generally addressed by methods of GC−MS and LC−MS. However, opiates do also show structural similarities to matrix molecules used in matrix-assisted laser desorption ionization (LDI) and may therefore ionize upon simple laser irradiation. Following this analytical approach, the present work thoroughly evaluated the direct detection of opiates by matrix-free LDI in crude extracts of P. somniferum. The method facilitated the identification of 10 reported opiates by their molecular formulas without any chromatographic prepurification. Moreover, a principal component analysis based on LDI-MS data permitted the correct grouping of all extracts according to their inherent chemistry. Concluding experiments on serial dilutions of thebaine further evaluated potential quantitative applications of the method. Overall results highlight the promising potential of LDI-MS for the swift detection of opiates in complex mixtures.

show abstract

Section: Resultsmentioning

confidence: 91%

Matrix-Free Laser Desorption Ionization Mass Spectrometry as an Efficient Tool for the Rapid Detection of Opiates in Crude Extracts of Papaver somniferum

Skopikova

Hashimoto

Richomme

et al. 2019

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…A carbon nanocoating was applied on the target plate using a Q150T ES deep-vacuum sputtering sys- [24]. The plant tissues were extracted using a pressurized liquid extraction system ASE-350 (Dionex, United States).…”

Section: Methodsmentioning

confidence: 99%

“…Previously we have proposed a new approach to recording MALDI mass spectra of low-molecularweight compounds using a carbon nanocoating (CNC) formed by the vacuum thermodesorption deposition of carbon on a target plate as a matrix [24]. A comparison of the efficiency of various types of carbon materials for the desorption/ionization of number of natural low-molecular-weight compounds (including betulin, one of representatives of PCTs) has shown that the highest intensity of analyte signals was attained using carbon nanotubes (CNTs).…”

Section: Introductionmentioning

confidence: 99%

Application of Carbon Matrices to Screening Pentacylic Triterpenoids in Plant Feedstock by MALDI Mass Spectrometry

et al. 2020

Self Cite

View full text Add to dashboard Cite

An approach based on the use of carbon matrices is proposed to obtain MALDI mass spectra of the most important secondary plant metabolites, pentacyclic triterpenoids (PCTs). The best results were obtained using carboxylated carbon nanotubes as a matrix; they form the most homogeneous solid phase with PCTs on a MALDI target plate surface. The cationization of analytes with lithium ions made it possible to obtain the most intense signals in the mass spectra of betulin, lupeol, and betulinic acid and ensured limits of detection for these analytes at a level of 15-25 ng. Because of the occurrence of side processes of the hydration and dehydration of cationized molecules, as well as of the replacement of labile protons by lithium ions, the resulting mass spectra are characteristic for various classes of PCTs and allow their reliable detection without using tandem mass spectrometry. The developed approach was successfully tested on real samples of birch bark extracts, and also on extracts from cranberry and lingonberry peels.

show abstract

“…The coatings were characterized by homogeneity, hydrophobicity, and high mechanical strength, which eliminated contamination of the mass spectrometer. The targets produced good spectral resolution and the absence of spectral interferences at low m / z values (Kosyakov et al, 2016).…”

Section: Matricesmentioning

confidence: 99%

Analysis of Carbohydrates and Glycoconjugates by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2015–2016

Harvey

2021

Mass Spectrometry Reviews

View full text Add to dashboard Cite

This review is the ninth update of the original article published in 1999 on the application of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2016. Also included are papers that describe methods appropriate to analysis by MALDI, such as sample preparation techniques, even though the ionization method is not MALDI. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation and arrays. The second part of the review is devoted to applications to various structural types such as oligo‐ and poly‐saccharides, glycoproteins, glycolipids, glycosides and biopharmaceuticals. Much of this material is presented in tabular form. The third part of the review covers medical and industrial applications of the technique, studies of enzyme reactions and applications to chemical synthesis. The reported work shows increasing use of combined new techniques such as ion mobility and the enormous impact that MALDI imaging is having. MALDI, although invented over 30 years ago is still an ideal technique for carbohydrate analysis and advancements in the technique and range of applications show no sign of deminishing. © 2020 Wiley Periodicals, Inc.

show abstract

Carbon nanocoatings: A new approach to recording mass spectra of low-molecular compounds using surface-assisted laser desorption/ionization mass spectrometry

Cited by 8 publications

References 13 publications

Matrix-Free Laser Desorption Ionization Mass Spectrometry as an Efficient Tool for the Rapid Detection of Opiates in Crude Extracts of Papaver somniferum

Matrix-Free Laser Desorption Ionization Mass Spectrometry as an Efficient Tool for the Rapid Detection of Opiates in Crude Extracts of Papaver somniferum

Application of Carbon Matrices to Screening Pentacylic Triterpenoids in Plant Feedstock by MALDI Mass Spectrometry

Analysis of Carbohydrates and Glycoconjugates by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2015–2016

Contact Info

Product

Resources

About