Carbon Nano-Onion-Decorated ZnO Composite-Based Enzyme-Less Electrochemical Biosensing Approach for Glucose

Abstract

This study investigates the enzyme-less biosensing property of the zinc oxide/carbon nano-onion (ZnO/CNO) nanocomposite coated on a glassy carbon electrode. The ZnO/CNO nanocomposite was synthesized using the ex situ mixing method, and the structural characterization was done using XRD, SEM, and TEM, whereas functional groups and optical characterization were done through FTIR and UV–visible spectroscopy. The electrochemical sensing response of the ZnO/CNO nanocomposite for the linear range of glucose concentration (0.1–15 mM) was examined using cyclic voltammetry (CV) with a potential window of −1.6 to +1.6 V using 0.1 M NaOH as an electrolyte. The ZnO/CNO nanocomposites showed enhanced sensing ability toward glucose with a sensitive value of 606.64 μA/mM cm2. Amperometric i-t measurement supports the finding of CV measurement and showed good sensing ability of the electrode ZnO/CNO nanocomposite material for up to 40 days. The enhanced electrocatalytic activity of the ZnO/CNO nanocomposite is explained due to the synergetic effect of both ZnO and CNO. Our findings suggest a high potential for ZnO/CNO nanocomposite-based glucose biosensors, which could be further utilized to develop noninvasive skin-attached sensors for biomedical applications.

XPS valence band observable light-responsive system for photocatalytic acid Red114 dye decomposition using a ZnO–Cu2O heterojunction

“…To investigate the chemical functionality, FT-IR experiments were performed for all the samples [ 31 , 32 ]. The FT-IR of the ZnO, ZnO–Cu 2 O and Cu 2 O is depicted in Fig.…”

Cu2O/MXene/rGO Ternary Nanocomposites as Sensing Electrodes for Nonenzymatic Glucose Sensors

“…From these CVs, a bar graph of the current response with different sensing elements in the presence and absence of glucose was plotted and is given in Figure f. The highest current change was observed for the MGA-75 composites as compared to the others related to the above observation of electrochemical properties such as a larger electrochemically active surface area, a synergistic effect of the MXene graphene aerogel with Cu 2 O (3D arrangement may enhance the adsorption of copper ions on the surface during the preparation of the Cu 2 O composite, which helps in more CuO or Cu­(OH) 2 ion formation for sensing of glucose), and a lower charge transfer resistance for the MGA-75 composites as compared to the others . For this composite, apart from the current increment, a wider CV curve in the presence of glucose was observed as compared to the others.…”

Biosensing Platforms for Cardiac Biomarker Detection

“…These bioreceptors can take the form of various biological entities, such as enzymes, antibodies, DNA aptamers, whole cells, and more . Among the most commonly used bioreceptors are enzymes and antibodies. , Transducers play a pivotal role in biosensors by converting the sensed form of energy, arising from the interaction between the bioreceptor and the analyte, into another form of energy, typically electrical. This transformation allows for the generation of a measurable signal that correlates with the presence or quantity of a chemical or biological target analyte.…”