Carbon Monoxide Uptake and Pulmonary Diffusing Capacity in Normal Subjects at Rest and During Exercise 1

Filley, Giles F.; Macintosh, D. J.; Wright, George W.

doi:10.1172/jci102923

Cited by 329 publications

(112 citation statements)

References 17 publications

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“…Our average value at 24-48 hr of age 1.52 f 0.09) falls within the ranges reported in human newborns at this age (6,9,12). These latter studies were all made using a steady state CO uptake technique (4).…”

Section: Discussionsupporting

confidence: 85%

Pulmonary Diffusing Capacity in Lambs during the Early Neonatal Period

et al. 1978

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Summarvwhen auiet they were intubated. Lambs in which re~eated studies were d a d e weie bottle fed. A rebreathing method was used to make 53 measurements Of DLco was measured by the rebreathing method (10) with slight pulmonary diffusing (D~CO) and capac-modifications for small animals, The volume of the rebreathing ity (FRC) in 17 newborn lambs during the first 2 days of life. D~eo, system was 400 and the lambs were ventilated from a 60-ml FRC, and DL~O/FRC all increased in studies made at 24-48 hr of syringe, The rebreathing circuit was made up of 3/16-inch ID age 'Ompared to those at 2-4 hr Of age: D~c o * 0'18 plastic tubing (Tygon tubing, Norton Plastics and Synthetics * Oeo9 ml/min/torr; FRC 37 * lo to 60 * m1 and DLcO/FRC Division, Akron, OH) which connected the endotracheal tube and 2.52 + 0.75 to 2.89 + 0.37 ml/min/torr/ml x D L~, measured ventilation syringe to a double headed pump (model no, using 0'005% C0 in the test gas was not different than that W21R031, Cole Palmer Instrument Company, Chicago, IL) where measured using 0.5% CO.the gas sample was split and run through a helium analyzer (Warren E. Collins Inc., Braintree, MA) and carbon monoxide Speculation analyzer (model no. 865 infrared analyzer, Beckman Instruments ~h~ increase in pulmonary diffusing capacity is in part due to Inc., Fullerton, CA) in parallel. The output of both analyzers was an increase in lung volume, but the significant increase in cOntinuOusl~ B44 P~~Y~~~P~, AssOciDLco/FRC demonstrates that other factors such as a change in ates In'., Beaverton, OR) at a paper 'peed of cm/sec. The pulmonary capillary blood volume may also be We entire rebreathing circuit was equilibrated with gas made up of conclude that there is no evidence for a co carrier in the early either 0.005 or 0.5% CO, 8.0% helium, 20.9% oxygen, and balance neonatal period in lambs. nitrogen (Airco Industrial Gases, Vancouver, WA). The circuit was then attached to the endotracheal tube at the end of expiration and the lamb rapidly rebreathed at 40-50 breaths/min with a tidal The is an index of the lung's capability for oxygen transport volume of 60 ml for 33-45 set. and is dependent upon alveolar volume and pulmonary capillary DLCO and FRC were calculated from the recorded changes in blood volume. Although DLco has been measured in human neo-CO and helium concentrations (Fig. 1) as follows nates (6, 9, 12), none of these studies have made a systematic = (0.693/t1/2) X Vs/BP -47 examination of the first 2 days of life. The early neonatal period involves the establishment of FRC (1,7,8) and the reabsorption where DLco = lung diffusing capacity in milliliters per min per of pulmonary fluid (2, 5, 1 I), which may in turn affect the volume torr STPD; t = time in minutes for [CO] to fall by 50%; Vs = of blood in the pulmonary capillary bed. We have measured DL~,, volume of the entire rebreathing system (rebreathing circuit plus and FRC by a rebreathing method in lambs in lambs at 2-4 hr of lung volume) in milliliters STPD; BP = barometric pressure in age and at 24-48...

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Section: Discussionsupporting

confidence: 85%

Pulmonary Diffusing Capacity in Lambs during the Early Neonatal Period

et al. 1978

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“…DL,, was measured using the steady state method of Filley and colleagues (8). Nondistressed infants were given 0.1 % carbon monoxide in room air.…”

Section: Methodsmentioning

confidence: 99%

“…Alveolar C O tension must therefore be estimated using the alveolar dead space equation (1 I), making the method extremely sensitive to variations in dead space volumes. Measurement of the diffusing capacity during exercise has been used in adults as a means of overcoming this difficulty (2,3,8), but this is not practical in the newborn infant. The method is also sensitive to leaks and lack of a steady state which affect the value of V,/V, used in the calculation of alveolar C O .…”

Section: Evaluation Of the Methodsmentioning

confidence: 99%

Carbon Monoxide Diffusing Capacity in Newborn Infants

1976

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ExtractIn order to test the role of diffusing capacity in determining the arterial oxygen tension of newborn infants, pulmonary diffusing capacity for carbon monoxide (DL,,) was measured in 21 healthy infants ranging in birth weight from 765 to 4,720 g. DL,, in infants without respiratory distress correlated well with lung volume ( r = 0.76, P < 0.001). A smaller correlation (r = 0.39, P < 0.01) was obtained between DL,, and arterial oxygen tension. D L , per unit volume of lung is similar when healthy premature infants, full term infants, and normal adults are compared.The wide range of normal values obtained in resting infants and the lack of correlation with arterial oxygen tensions are similar to observations made in adults. SpeculationDiffusion "block" was not demonstrable in this study, even in infants with mild hypoxemia. These data, in conjunction with other studies reviewed in this report, suggest that lung volume plays a critical role in the level of arterial oxygen tension in newborn infants.

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“…A number of papers have been published in which measurements of the rate of gas diffusion in disease have been presented. A steady state Dco technique devised by Filley, MacIntosh, and Wright (5) has been used in a study of a variety of patients with pulmonary fibrosis (3,6). The oxygen method has been used in studies of sarcoidosis (7), emphysema (2), mitral stenosis (8), and a number of other conditions.…”

mentioning

confidence: 99%

The Measurement of the Pulmonary Diffusing Capacity in the Presence of Lung Disease

Bates¹

1958

J. Clin. Invest.

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Carbon Monoxide Uptake and Pulmonary Diffusing Capacity in Normal Subjects at Rest and During Exercise 1

Cited by 329 publications

References 17 publications

Pulmonary Diffusing Capacity in Lambs during the Early Neonatal Period

Pulmonary Diffusing Capacity in Lambs during the Early Neonatal Period

Carbon Monoxide Diffusing Capacity in Newborn Infants

The Measurement of the Pulmonary Diffusing Capacity in the Presence of Lung Disease

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