Carbon monoxide-releasing molecule-2 ameliorates postresuscitation myocardial dysfunction in rat via mitochondrial-mediated apoptosis pathway and the regulation of mitochondrial dynamics

Liu, Min; Du, Fang; Liu, Fang; Wang, Xiaohong

doi:10.1016/j.ejphar.2022.175038

Cited by 7 publications

(1 citation statement)

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“…OPA1 is located in the inner mitochondrial membrane and mediates the fusion of the inner membrane ( Rovira-Llopis et al, 2017 ). However, the expression patterns of the genes related to mitochondrial fission and fusion were the same in this experiment, which differs from the opposite patterns commonly seen in studies related to mitochondrial dynamics ( Wang et al, 2022b ; Liu et al, 2022 ). We hypothesize that the reduction of those genes means the inhibition of mitophagy.…”

Section: Discussioncontrasting

confidence: 86%

Cinnamaldehyde regulates mitochondrial quality against hydrogen peroxide induced apoptosis in mouse lung mesenchymal stem cells via the PINK1/Parkin signaling pathway

Zhu

Lan

et al. 2022

PeerJ

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Background Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease without effective treatments. Mitochondrial dysfunction weakens the ability of mesenchymal stem cells (MSCs) to repair the distal lung epithelium, which is a probable pathogenesis of IPF. In previous research, we found that cinnamaldehyde (CA) can maintain the mitochondrial morphology of MSCs. Methods This present study evaluated the effect and mechanism of CA on murine lung MSCs using the hydrogen peroxide model. Antioxidant effects and mitochondrial function were determined using flow cytometry. The mRNA levels of mitochondrial dynamics and the expressions of autophagy-related proteins were also detected. Results CA can increase the levels of SOD, MMP and ATP, decrease the rate of ROS and apoptosis, and restore the mitochondrial structure. CA can also improve the mRNA expression of MFN1, MFN2, FIS1, DRP1, OPA1, and PGC-1α, increase the expression of LC3 II and p62 and promote the PINK1/Parkin signaling pathway. Our results demonstrated that CA can control mitochondrial quality and avoid apoptosis, which may be associated with the regulation of the PINK1/Parkin signaling pathway.

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Section: Discussioncontrasting

confidence: 86%