Carbon Monoxide Poisoning

Goldstein, Mark

doi:10.1016/j.jen.2007.11.014

Cited by 161 publications

(134 citation statements)

References 19 publications

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“…Exogenous CO is poisonous to humans, impairing the O 2 carrying capacity of Hb [1,7,8,12]. However, eukaryotic organisms use endogenous CO, produced during heme degradation by the highly conserved HO enzymes [2][3][4]12,26,27], as a neurotransmitter and as a physiological signal molecule [12,21,152].…”

Section: Discussionmentioning

confidence: 99%

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CO metabolism, sensing, and signaling

et al. 2011

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Abstract.CO is a colorless and odorless gas produced by the incomplete combustion of hydrocarbons, both of natural and anthropogenic origin. Several microorganisms, including aerobic and anaerobic bacteria and anaerobic archaea, use exogenous CO as a source of carbon and energy for growth. On the other hand, eukaryotic organisms use endogenous CO, produced during heme degradation, as a neurotransmitter and as a signal molecule. CO sensors act as signal transducers by coupling a ''regulatory'' heme-binding domain to a ''functional'' signal transmitter. Although high CO concentrations inhibit generally heme-protein actions, low CO levels can influence several signaling pathways, including those regulated by soluble guanylate cyclase and/or mitogenactivated protein kinases. This review summarizes recent insights into CO metabolism, sensing, and signaling.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, despite its toxicity [1,7,8], CO plays a key role in several metabolic processes and in diverse signal transduction pathways in bacteria, archaea, and eukaryotes [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

CO metabolism, sensing, and signaling

et al. 2011

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“…Safety limit of the manhole gases are as follows. Safety limit of NH 3 is laying between 25 -40ppm (as per limit set by World Health Organization), CO is in between 35 -100ppm [40,41,42], H 2 S is in between 50 -100ppm [43,44], CO 2 is in between 5000 -8000ppm [42,45] and CH 4 is on between 5000 -10000 ppm [46].…”

Section: Resultsmentioning

confidence: 99%

Convergence Analysis of Backpropagation Algorithm for Designing an Intelligent System for Sensing Manhole Gases

Ojha

Dutta

Chaudhuri

et al. 2015

Hybrid Soft Computing Approaches

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Human fatalities are reported due to the excessive proportional presence of hazardous gas components in manhole, such as Hydrogen Sulfide, Ammonia, Methane, Carbon Dioxide, Nitrogen Oxide, Carbon Monoxide, etc. Hence, predetermination of these gases is imperative. A neural network (NN) based intelligent sensory system is proposed for the avoidance of such fatalities. Backpropagation (BP) was applied for the supervised training of the neural network. A Gas sensor array consists of many sensor elements was employed for the sensing manhole gases. Sensors in the sensor array are responsible for sensing their target gas components only. Therefore, the presence of multiple gases results in cross sensitivity. The cross sensitivity is a crucial issue to this problem and it is viewed as pattern recognition and noise reduction problem. Various performance parameters and complexity of the problem influences NN training. In present chapter the performance of BP algorithm on such a real life application problem was comprehensively studied, compared and contrasted with the several other hybrid intelligent approaches both, in theoretical and in statistical sense.

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“…The control group was treated in similar manner to the treatment one except for the CO exposure and the 30 minutes postmortem sample collection. The CO gas was produced using one stroke generator (SUMEC) and acute concentrations extrapolated from the findings of Golden [17], and Struttmann et al, [18].…”

Section: Study Populationmentioning

confidence: 99%

“…The concentration of CO was extrapolated from the findings of Golden [17], and Struttmann et al, [18] in averring CO concentrations (ppm) that can lead to death and its corresponding carboxyhaemoglobin.…”

Section: Laboratory Analysismentioning

confidence: 99%