Carbon Monoxide-Bound Red Blood Cell Resuscitation Ameliorates Hepatic Injury Induced by Massive Hemorrhage and Red Blood Cell Resuscitation via Hepatic Cytochrome P450 Protection in Hemorrhagic Shock Rats

Correlation between adiponectin and hemorrhagic shock in mice

“…HS is accompanied by many complications, the most evident of which is disseminated intravascular coagulation, which leads to the dysfunction of circulatory (and other internal organ) function, secondary fibrinolysis and consumptive coagulopathy. These complications will result in shock, hemorrhage, thrombosis, and hemolysis Ogaki et al, 2014). Therefore, various means should be employed in the treatment of HS, such as ensuring airway ventilation, providing endotracheal intubation and mechanical ventilation, and conducting immediate hemostasis (Ogaki et al, 2014;Zhao et al, 2014).…”

“…These complications will result in shock, hemorrhage, thrombosis, and hemolysis Ogaki et al, 2014). Therefore, various means should be employed in the treatment of HS, such as ensuring airway ventilation, providing endotracheal intubation and mechanical ventilation, and conducting immediate hemostasis (Ogaki et al, 2014;Zhao et al, 2014). Adiponectin (ADPN) has a pronounced effect on vascular endothelial function; thus, much attention has and should be paid to the relationship between ADPN and HS (Lim et al, 2014).…”

Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1/TLR-4 pathway during resuscitation from hemorrhagic shock

“…Hemorrhagic shock model rats were prepared by removing 40% of the total blood volume according to our previous report [5,16]. Under these experimental conditions, the mean arterial pressure remained at less than 40 mm Hg for 30 min.…”

“…The washed RBC resuscitative fluid was prepared from donor rats as described in a previous report [5,16], and the hemoglobin (Hb) concentration of the RBC resuscitative fluid was subsequently adjusted to 10 g/dL. CO-RBC resuscitative fluid was prepared by gently bubbling CO gas through the RBC resuscitative fluid.…”

The Therapeutic Potential of Carbon Monoxide for Inflammatory Bowel Disease

“…It has been reported that CO in the organ preservation solution that is used during kidney transplantation can bind to and stabilize renal CYP and prevent CYP degradation and detrimental heme release in renal grafts [19]. In addition, it has been reported that CO-bound red blood cells reduce hepatic ischemia-reperfusion (I-R) injury through the inhibition of CYP destruction [20]. …”