Carbon Monoxide and Other Tissue Poisons

Jain, K. K.

doi:10.1007/978-3-319-47140-2_13

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…Carbon monoxide (CO) CO toxicity occurs due to the synergistic effect of tissue hypoxia as well as direct CO-mediated cell damage [44]. The affinity of CO to hemoglobin is approximately 210 times more than O 2 .…”

Section: Air Pollutants Induced Cellular Toxicity Dna Damage and Apmentioning

confidence: 99%

A review on effect of air pollutants on fetal development and pregnancy outcomes

Kashyap

Gupta

Mansuri

et al. 2019

JAPH

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Developing fetus is connected to the mother by placenta to receive oxygen and nutrients. Maternal exposure to ambient air pollution not only affects maternal health but also provides a pathway for many toxic pollutants to cross the placental barrier and interrupt biochemical milieu. There are numerous scientific studies available describing possible negative health impact of air pollutants on reproductive health, pregnancy outcomes and fetal development yet no toxic effect is available recently. Studying the pollutants exposure effect on fetal development is crucial for the underlying mechanism between prenatal exposure and pregnancy outcomes. Present review meticulously provides the compiled data of 40 most recent studies with possible action mechanism of air pollutants on pregnancy outcomes and fetal development to find a better solution to exterminate or reduce the problem.

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Section: Air Pollutants Induced Cellular Toxicity Dna Damage and Apmentioning

confidence: 99%

A review on effect of air pollutants on fetal development and pregnancy outcomes

Kashyap

Gupta

Mansuri

et al. 2019

JAPH

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“…Rather, accumulation of CO within the tissues following unloading of CO from hemoglobin is the key factor that determines the degree of cellular toxicity (Hampson, 2012). Diffusion of CO into the various tissue compartments following exposure is dictated by the Haldane equation and is based on both COHb level and CO tension within the tissue (Figure 1) (Jain, 2009). Thus, resultant COHb concentrations are of central importance and higher levels will lead to greater tissue CO delivery.…”

Section: Environmental Co and Overt Toxicitymentioning

confidence: 99%

Carbon monoxide pollution and neurodevelopment: A public health concern

Levy¹

2015

Neurotoxicology and Teratology

112

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Although an association between air pollution and adverse systemic health effects has been known for years, the effect of pollutants on neurodevelopment has been underappreciated. Recent evidence suggests a possible link between air pollution and neurocognitive impairment and behavioral disorders in children, however, the exact nature of this relationship remains poorly understood. Infants and children are uniquely vulnerable due to the potential for exposure in both the fetal and postnatal environments during critical periods in development. Carbon monoxide (CO), a common component of indoor and outdoor air pollution, can cross the placenta to gain access to the fetal circulation and the developing brain. Thus, CO is of particular interest as a known neurotoxin and a potential public health threat. Here we review overt CO toxicity and the policies regulating CO exposure, detail the evidence suggesting a potential link between CO-associated ambient air pollution, tobacco smoke, and learning and behavioral abnormalities in children, describe the effects of subclinical CO exposure on the brain during development, and provide mechanistic insight into a potential connection between CO exposure and neurodevelopmental outcome. CO can disrupt a number of critical processes in the developing brain, providing a better understanding of how this specific neurotoxin may impair neurodevelopment. However, further investigation is needed to better define the effects of perinatal CO exposure on the immature brain. Current policies regarding CO standards were established based on evidence of cardiovascular risk in adults with pre-existing comorbidities. Thus, recent and emerging data highlighted in this review regarding CO exposure in the fetus and developing child may be important to consider when the standards and guidelines are evaluated and revised in the future.

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“…Interpretation of studies evaluating the potential therapeutic effect of CO should be carried out cautiously given the importance of oxygen tension and oxyhemoglobin saturation in determining the tissue delivery of CO. 95,96 Drawing definitive conclusions about the effects of specific CO concentrations becomes difficult without explicit measurement of such variables. Furthermore, the lack of hemoglobin and its impact on CO binding and diffusion with in vitro experimentation must be taken into account when interpreting the effect of CO exposure of cells and tissue in culture.…”

Section: Biologic Effects Of Comentioning

confidence: 99%

Anesthesia-Related Carbon Monoxide Exposure: Toxicity and Potential Therapy

Levy

2016

Anesthesia &Amp; Analgesia

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Exposure to carbon monoxide (CO) during general anesthesia can result from volatile anesthetic degradation by carbon dioxide absorbents as well as re-breathing of endogenously produced CO. Although adherence to the Anesthesia Patient Safety Foundation guidelines reduces the risk of CO poisoning, patients may still experience a sub-toxic CO exposure during low-flow anesthesia. The consequences of such exposures are relatively unknown. In contrast to the widely recognized toxicity of high CO concentrations, the biological activity of low concentration CO has recently been shown be cytoprotective. As such, low dose CO is being explored as a novel treatment for a variety of different diseases. Here we review the concept of anesthesia-related CO exposure, identify the sources of production, detail the mechanisms of overt CO toxicity, highlight the cellular effects of low dose CO, and discuss the potential therapeutic role for CO as a part of routine anesthetic management.

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Carbon Monoxide and Other Tissue Poisons

Cited by 7 publications

References 41 publications

A review on effect of air pollutants on fetal development and pregnancy outcomes

A review on effect of air pollutants on fetal development and pregnancy outcomes

Carbon monoxide pollution and neurodevelopment: A public health concern

Anesthesia-Related Carbon Monoxide Exposure: Toxicity and Potential Therapy

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