Carbon ion radiotherapy for stage I non-small cell lung cancer

Miyamoto, Tadaaki; Yamamoto, Naoyoshi; Nishimura, Hideki; Koto, Masashi; Tsujii, Hirohiko; Mizoe, Jun‐etsu; Kamada, Tadashi; Kato, Hirotoshi; Yamada, Shigeru; Morita, Shinroku; Yoshikawa, Ken; Kandatsu, Susumu; Fujisawa, Takehiko

doi:10.1016/s0167-8140(02)00367-5

Cited by 197 publications

(108 citation statements)

References 34 publications

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“…In the latter, the clinical aim of maximizing damage in the tumor sites while minimizing damages to healthy surrounding tissue has lead to the use of protons and, more recently, carbon ions to provide high spatial-specifi c damage profi les [13][14][15][16][17][18]. In radiation or particle therapy there is a possibility that the particle interacts directly with critical components of the cell or with water.…”

Section: C-ion Therapymentioning

confidence: 99%

“…As these radicals are extremely reactive, the diffusion length must be within about 20Å from the target. Recently, good effective radiotoxic responses from C-ion tumor therapy was reported [14][15][16][17][18]. The high ionization densities within the Bragg peak make normal DNA enzymatic repair diffi cult in contrast to low LET (Linear Energy Transfer) electron, proton and photon irradiation [13].…”

Section: C-ion Therapymentioning

confidence: 99%

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Primary radicals production from water fragmentation by heavy ions

Montenegro¹,

Luna²

2005

Braz. J. Phys.

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The importance of fragmentation of water molecules by heavy ions is discussed for several different physical environments, including tumor treatment, planetary sciences and fi ssion reactors. The characteristics of the fragmentation yields by electrons, protons and photons are presented and compared with fragmentation yields of water molecules by C 3+ and O 5+ ions at energies corresponding to the Bragg peak. It is shown that for low energy electron loss and high energy electron capture, the water molecules essentially blow-out, releasing a much larger fraction of O q+ ions as compared with electrons, protons and photons.

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Section: C-ion Therapymentioning

confidence: 99%

Section: C-ion Therapymentioning

confidence: 99%

Primary radicals production from water fragmentation by heavy ions

Montenegro¹,

Luna²

2005

Braz. J. Phys.

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“…The neutron experience taught us that late effects of high-LET radiations can have a higher RBE than the acute effects from neutrons [119]. A handicap in the evaluation of late effects is that the follow-up time of patients treated with carbon or neon ions is considerably shorter than patients treated with protons [23,25,57,70,78,79,98,99,111,112].…”

Section: Carbon Ion Beam Radiation Therapymentioning

confidence: 99%

Late effects from hadron therapy

Blakely

Chang

2004

Radiotherapy and Oncology

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Successful cancer patient survival and local tumor control from hadron radiotherapy warrant a discussion of potential secondary late effects from the radiation. The study of late-appearing clinical effects from particle beams of protons, carbon, or heavier ions is a relatively new field with few data. However, new clinical information is available from pioneer hadron radiotherapy programs in the USA, Japan, Germany and Switzerland. This paper will review available data on late tissue effects from particle radiation exposures, and discuss its importance to the future of hadron therapy.Potential late radiation effects are associated with irradiated normal tissue volumes at risk that in many cases can be reduced with hadron therapy. However, normal tissues present within hadron treatment volumes can demonstrate enhanced responses compared to conventional modes of therapy. Late endpoints of concern include induction of secondary cancers, cataract, fibrosis, neurodegeneration, vascular damage, and immunological, endocrine and hereditary effects. Low-dose tissue effects at tumor margins need further study, and there is need for more acute molecular studies underlying late effects of hadron therapy.2

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“…Carbon ions were selected for clinical trials, because they have the biologic characteristics of high LET, with 78 KeV/m at the distal end of the spread-out Bragg peak (SOBP), and because they show good dose-localizing properties compared with heavier ions. These advantages have been shown in various cancers 3,16,27,28,33,36) . Preliminary results of phase II clinical trials have shown extremely favorable therapeutic results in the treatment of head and neck cancers (including oral cancers) that were otherwise intractable with conventional photon radiation 16,27) .…”

Section: Introductionmentioning

confidence: 96%

“…The efficacy of carbon ion therapy has been demonstrated in clinical trials at the National Institute of Radiological Sciences (NIRS), Chiba, Japan, since 1994 16,27,29,40) . Carbon ions were selected for clinical trials, because they have the biologic characteristics of high LET, with 78 KeV/m at the distal end of the spread-out Bragg peak (SOBP), and because they show good dose-localizing properties compared with heavier ions.…”

Section: Introductionmentioning

confidence: 99%

Genetic Effects of X-Ray and Carbon Ion Irradiation in Head and Neck Carcinoma Cell Lines

Yamamoto

Ikeda

Yakushiji

et al. 2007

Bull. Tokyo Dent. Coll.

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The effects of X-ray and carbon ion irradiation on DNA and genes in head and neck carcinoma cells were examined. Four head and neck cancer cell lines (squamous cell carcinoma, salivary gland cancer, malignant melanoma, normal keratinocyte) were treated with 1, 4, and 7 GyE of carbon ion, or 1, 4, and 8 Gy of X-ray, respectively. DNA and RNA in the treated cells were extracted and purified. PCR-LOH (polymerase chain reactionloss of heterozygosity) analysis with 6 microsatellite regions on chromosome 17 was performed to determine DNA structural damage, and then microarray analysis was performed to reveal changes in gene expression. PCR-LOH analysis detected high LOH in cells treated by radiation, indicating that most of the damage by X-ray occurred in the target region on one of the homologous chromosomes. However, carbon ion caused homodeletion, which means deletion of the counterparts in both homologous chromosomes.

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Carbon ion radiotherapy for stage I non-small cell lung cancer

Cited by 197 publications

References 34 publications

Primary radicals production from water fragmentation by heavy ions

Primary radicals production from water fragmentation by heavy ions

Late effects from hadron therapy

Genetic Effects of X-Ray and Carbon Ion Irradiation in Head and Neck Carcinoma Cell Lines

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