Carbon ion radiotherapy for elderly patients 80 years and older with stage I non-small cell lung cancer

[11C]Gefitinib ([11C]Iressa): Radiosynthesis, In Vitro Uptake, and In Vivo Imaging of Intact Murine Fibrosarcoma

“…In our institute, CIRT has been used to treat patients with various cancers such as bone and soft tissue sarcoma, rectal cancer, and NSLC [17][18][19]. Our aim was to apply [ 11 C] gefitinib PET to evaluate the effect of CIRT in clinical treatment.…”

“…PET is a powerful modality to determine the efficacy of radiotherapy and to monitor the different functions (receptor, sugar metabolism, and nucleic acid synthesis) of tumor cells [15,16]. In our institute, carbon-ion radiotherapy (CIRT) using a carbon-ion beam was started in 1994, and more than 3,000 patients suffering from malignant diseases, including NSCLC, have been treated by CIRT [17][18][19]. PET with [ 11 C]methionine has been used to monitor the response of CIRT in patients with bone and soft tissue sarcoma and rectal cancer [20,21].…”

Comparison of the Effects of Carbon Ion and Photon Irradiation on the Angiogenic Response in Human Lung Adenocarcinoma Cells

“…Apart from tumor treatment with photon irradiation, carbon ion radiation therapy is emerging as an alternative option for various tumor entities, including lung tumors (7,8). Carbon ion irradiation provides both physical and biological advantages, such as the inverted dose-depth profile in tissue and an increased relative biological effectiveness (RBE) in the tumor region (9) and, thus, is promising for the treatment of radiotherapy-resistant cancers (7,8).…”

Do We Have Enough Evidence to Implement Particle Therapy as Standard Treatment in Lung Cancer? A Systematic Literature Review

“…Taking the most recent publications into account, the percentages of late toxicities were similar in the group of patients receiving proton therapy (and even lower after treatment with C-ions) and in the group of patients receiving SRT-proton therapy, 10% (grade 2) [30]; C-ion therapy, 4% (grade 2) [31,39]; photon SRT, 9%(grade 2-5; range, 5%-27%) [47,52,55,56]. Even in a subgroup of elderly patients, C-ion radiotherapy seemed to be a safe treatment modality [33]. Because of the relatively low number of patients evaluated so far, the results regarding late severe toxicities after particle therapy should be interpreted with caution.…”

“…Sugane et al [33], who investigated elderly patients aged Ն80 years, reported no severe acute or late side effects in that subgroup of patients (n ϭ 28).…”