Carbon in airway macrophages from children with asthma

Brugha, Rossa; Mushtaq, Naseem; Round, Thomas; Gadhvi, Dev; Dundas, Isobel; Gaillard, Erol; Koh, Lee; Fleming, Louise; Lewis, Daniel; Sanak, Marek; Wood, Helen E.; Barratt, Benjamin; Mudway, Ian; Kelly, Frank J.; Griffiths, Christopher J.; Grigg, Jonathan

doi:10.1136/thoraxjnl-2013-204734

Cited by 32 publications

(29 citation statements)

References 32 publications

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“…Kulkarni et al (2006) also found that asthmatic children had, surprisingly, much lower carbon loading in AM than healthy children. This finding has been further validated in a recently published study involving three groups of children that showed carbon loading to be 51% lower in children with moderate-to-severe asthma than in those with mild asthma and in healthy children (Brugha et al, 2014). The reason was speculated to be a result of impaired phagocytosis by AM in severe asthma (Brugha et al, 2014).…”

Section: Studymentioning

confidence: 59%

“…This finding has been further validated in a recently published study involving three groups of children that showed carbon loading to be 51% lower in children with moderate-to-severe asthma than in those with mild asthma and in healthy children (Brugha et al, 2014). The reason was speculated to be a result of impaired phagocytosis by AM in severe asthma (Brugha et al, 2014). To contrast, AM in healthy subjects can engulf particles rapidly (Alexis et al, 2006).…”

Section: Studymentioning

confidence: 65%

“…Airway inflammation will thus lead to a lower percentage of macrophages in a sputum sample in comparison to healthy controls (Brugha et al, 2014;Kulkarni et al, 2006). It is not known whether inflammation will affect the proportion of macrophages containing BC, and hence act as a confounder in the relation between exposure to pollutant and AM BC.…”

Section: Confounding Factors and Limitationsmentioning

confidence: 98%

“…Background PM 10 measured by monitoring station. Brugha et al (2014) London, UK Healthy children (mean age 9.3 years, n = 47), children with mild asthma (mean age 9.4 years, n = 13), children with moderate to severe asthma (mean age 11.6 years, n = 36) IS Traffic.…”

Section: Ismentioning

confidence: 99%

See 3 more Smart Citations

Carbon loading in airway macrophages as a biomarker for individual exposure to particulate matter air pollution — A critical review

Bai

Brugha

Jacobs

et al. 2015

Environment International

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Section: Studymentioning

confidence: 59%

Section: Studymentioning

confidence: 65%

Section: Confounding Factors and Limitationsmentioning

confidence: 98%

Section: Ismentioning

confidence: 99%

See 2 more Smart Citations

Carbon loading in airway macrophages as a biomarker for individual exposure to particulate matter air pollution — A critical review

Bai

Brugha

Jacobs

et al. 2015

Environment International

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“…Pollution leads to the accumulation of carbon particles in alveolar macrophages, but there is less carbon in macrophages of children with severe asthma 23. Is this due to impaired macrophage function in these children?…”

Section: Paediatric Year In Reviewmentioning

confidence: 99%

Year in review 2014. Paediatric and adult clinical studies

Bush

Pavord

2015

Thorax

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Auswirkungen von Schadstoffen der Außenluft auf den kindlichen Respirationstrakt

Frischer

2015

Wien Med Wochenschr

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The exposure against common air pollutants such as NO2, PM10 and SO2 has decreased in the last decades due to efforts of the EC to reduce emissions of industrial or traffic related origins. However, ozone exposure demonstrates an upward trend. New epidemiologic studies use geographical information systems for a more precise special and temporal categorisation of exposure. They show adverse effects of ultrafine particles as well as elemental carbon on the respiratory system of children. Children growing up next to busy traffic routes are most affected. Adverse effects include respiratory symptoms as well as a delay in lung growth. Intrauterine exposure against PM10 seems to effect lung function in newborns. There is a lack of data about other organic substances widely used in synthetic materials in the outdoor air such as phthalates or bisphenols, some studies show detrimental effects.

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Carbon in airway macrophages from children with asthma

Cited by 32 publications

References 32 publications

Carbon loading in airway macrophages as a biomarker for individual exposure to particulate matter air pollution — A critical review

Carbon loading in airway macrophages as a biomarker for individual exposure to particulate matter air pollution — A critical review

Year in review 2014. Paediatric and adult clinical studies

Auswirkungen von Schadstoffen der Außenluft auf den kindlichen Respirationstrakt

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