Carbon Electrode Modified with Molecularly Imprinted Polymers for the Development of Electrochemical Sensor: Application to Pharmacy, Food Safety, Environmental Monitoring, and Biomedical Analysis

Bou-Maroun, Elias

doi:10.3390/chemosensors11110548

Cited by 6 publications

(2 citation statements)

References 92 publications

(105 reference statements)

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“…27,28 A plethora of publications detailing the implementation of MIPs in numerous drug assessments have been reported in recent years. 27,29,30 Molecular imprinting is the method of inducing sites for identifying a particular molecule within the polymer substance by using a template and a functional monomer. This procedure involves polymerizing a combination of monomer materials surrounding a selected target that serves as a template.…”

Section: Introductionmentioning

confidence: 99%

“…It is theoretically possible to manufacture imprinted polymers for any desired analyte. As many as 10,000 chemicals and biological components including inorganic ions, pharmaceuticals, nucleic acids, proteins, and even organisms have all been efficiently imprinted. , A plethora of publications detailing the implementation of MIPs in numerous drug assessments have been reported in recent years. ,, …”

Section: Introductionmentioning

confidence: 99%

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Development and Fabrication of a Molecularly Imprinted Polymer-Based Electroanalytical Sensor for the Determination of Acyclovir

Al Faysal,

Cetinkaya,

Kaya

et al. 2024

ACS Omega

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Acyclovir (ACV), a synthetic nucleoside derivative of purine, is one of the most potent antiviral medications recommended in the specific management of varicella-zoster and herpes simplex viruses. The molecularly imprinted polymer (MIP) was utilized to create an effective and specific electrochemical sensor using a straightforward photopolymerization process to determine ACV. The polymeric thin coating was developed using the template molecule ACV, a functional monomer acrylamide, a basic monomer 2-hydroxyethyl methacrylate, a cross-linker ethylene glycol dimethacrylate, and a photoinitiator 2-hydroxy-2-methyl propiophenone on the exterior of the glassy carbon electrode (GCE). Scanning electron microscopy, attenuated total reflectance−Fourier transform infrared spectroscopy, electrochemical impedance spectroscopy, and cyclic voltammetry were employed for the purpose of characterizing the constructed sensor (AM-ACV@MIP/GCE). Differential pulse voltammetry and a 5 mM ferrocyanide/ferricyanide ([Fe(CN) 6 ] 3−/4− ) redox reagent were used to detect the ACV binding to the specific cavities on MIP. The study involves density functional theory (DFT) calculations, which were conducted to investigate template-functional monomer interactions thoroughly, calculate template-functional monomer interaction energies, and determine the optimal template/functional monomer ratio. DFT calculations were performed using Becke's three-parameter hybrid functional with the Lee−Yang−Parr correlation functional (B3LYP) method and 6-31G(d,p) basis set. The sensor exhibits linear performance throughout the concentration region 1 × 10 −11 to 1 × 10 −10 M, and the limit of detection and limit of quantification were 7.15 × 10 −13 M and 2.38 × 10 −12 M, respectively. For the electrochemical study of ACV, the sensor demonstrated high accuracy, precision, robustness, and a short detection time. Furthermore, the developed electrochemical sensor exhibited exceptional recovery in tablet dosage form and commercial human blood samples, with recoveries of 99.40 and 100.44%, respectively. The findings showed that the AM-ACV@MIP/GCE sensor would effectively be used to directly assess pharmaceuticals from actual specimens and would particularly detect ACV compared to structurally similar pharmaceutical compounds.

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