Carbon dots with two-photon fluorescence imaging for efficient synergistic trimodal therapy

Zhang, Yahui; Xia, Haoyu; Yang, Mengdie; Li, Hairong; Shan, Feishi; Chen, Yilong; Yue, Xue; Wang, Zhouyu; Yu, Xiao‐Qi

doi:10.1016/j.cclet.2023.108197

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…The O-CDs exhibited excellent white-light generation for type I ROS and good photothermal conversion under laser irradiation at 808 nm. ·OH generated by the type I PDT can trigger the conversion of native (M2) macrophages to antitumor (M1) macrophages, for application to immunotherapy …”

Section: Sensing and Imaging Applications Of Cds-based Sensorsmentioning

confidence: 99%

“…Because 0D CNMs nanoparticles exhibit excellent biocompatibility, traces of 0D CNMs can enter and circulate around the bloodstream and, thus, be transported throughout the body to organs, such as the brain, heart, lungs, liver, and kidneys. ,, Overall, 0D CNMs are usually easily excreted from the body, without being metabolized, and predominantly eliminated through renal (urine) and hepatic (bile-to-feces) excretion and some secondary pathways, including the tears, sweat, saliva, and breath. Although renal excretion requires only hours to days, hepatic excretion requires hours to months. , After a long time, if nanoparticles have not been thoroughly metabolized, they are possibly deposited in the body, which leads to chronic toxicity and an inflammatory stress response .…”

Section: Optical Properties Of 0d Cnmsmentioning

confidence: 99%

“…• OH generated by the type I PDT can trigger the conversion of native (M2) macrophages to antitumor (M1) macrophages, for application to immunotherapy. 453 The success of gene therapy relies on the generation of a vector that can efficiently and selectively deliver genes to target cells at a low toxicity. Low-toxicity CDs exhibiting a high quantum yield, low photobleaching, good water solubility, easy surface modification, and chemical stability are emerging as gene-delivering nanocarriers.…”

Section: Sensing and Imaging Applications Of Cds-based Sensorsmentioning

confidence: 99%

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Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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Advances in nanotechnology and nanomaterials have attracted considerable interest and play key roles in scientific innovations in diverse fields. In particular, increased attention has been focused on carbon-based nanomaterials exhibiting diverse extended structures and unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, carbon nanodiamonds, and carbon dots, possess excellent bioaffinities and superior fluorescence properties that make these structures suitable for application to environmental and biological sensing, imaging, and therapeutics. This review provides a systematic overview of the classification and structural properties, design principles and preparation methods, and optical properties and sensing applications of zero-dimensional carbon nanomaterials. Recent interesting breakthroughs in the sensitive and selective sensing and imaging of heavy metal pollutants, hazardous substances, and bioactive molecules as well as applications in information encryption, super-resolution and photoacoustic imaging, and phototherapy and nanomedicine delivery are the main focus of this review. Finally, future challenges and prospects of these materials are highlighted and envisaged. This review presents a comprehensive basis and directions for designing, developing, and applying fascinating fluorescent sensors fabricated based on zero-dimensional carbon nanomaterials for specific requirements in numerous research fields.

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Section: Sensing and Imaging Applications Of Cds-based Sensorsmentioning

confidence: 99%

Section: Optical Properties Of 0d Cnmsmentioning

confidence: 99%

Section: Sensing and Imaging Applications Of Cds-based Sensorsmentioning

confidence: 99%

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Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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“…Photodynamic therapy (PDT) has become a promising treatment for cancer – and can be divided into two mechanisms: type I and type II. , CDs have been extensively reported for PDT due to the outstanding optical properties and good biocompatibility . Since CDs-based photosensitizers (PS) were first developed by Chen’s group for type II PDT guided by near-infrared fluorescence imaging, many CDs-based type II PS have been widely developed for tumor therapy. – Unfortunately, hypoxia is one of the most prominent features of solid tumors, which greatly limits the application of PS in the type II PDT process in cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Carbonized Polymer Dots with Aggregation-Induced Effect for Type I Photodynamic Therapy

Liao

Zhu

et al. 2023

ACS Appl. Nano Mater.

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Carbonized polymer dots (CPDs) have attracted great interest as a nanomaterial in biomedical applications, especially in imaging and photodynamic therapy (PDT). However, CPDs with an aggregation-induced effect for type I PDT has been rarely reported. In this work, N,N′-dimethylurea and citric acid were used as precursors to prepare CPDs (YCPDs) with aggregation-induced effect in one pot by the solvothermal method. The YCPDs have a yellow emission of 550 nm and a high quantum yield of 68%, which lays a solid foundation for cell imaging. In addition, YCPDs can produce • O 2 − under white light irradiation and obtain • OH through electron transfer or hydrogen atom abstraction. In vitro results show that YCPDs possess great cytocompatibility but exert severe cytotoxicity to HeLa cells with only 2% of cell viability when exposed to ultralow-power-intensity (2.5 mW/cm 2 ) light irradiation. Therefore, YCPDs, as a promising type I PDT nanomaterial, have a great potential for cancer therapy.

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“…Intracellular fluorescent imaging is also convenient for practical monitoring of metal ions and biomolecules . Carbon nanodots (CDs) have been considered as a promising candidate for fluorescent materials in bioimaging, biosensing, drug delivery, catalysis, energy conversion, and so on. − CDs have attracted enormous attention due to their properties like excellent water solubility, high emission, easy functionalization, low toxicity, and so on . Herein, we have prepared bright green-emissive CDs with high quantum yield (QY) using carbon sources of [2,2′-bipyridine]-5,5′-diamine and dicyandiamide.…”

mentioning

confidence: 99%

Bright Green-Emissive Carbon Nanodots for Sensing and Intracellular Imaging of Cu²⁺ and Glutathione

Guo

Zhu

2023

ACS Appl. Bio Mater.

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Green-emissive carbon nanodots (CDs) with high quantum yield are prepared. The abundant functional groups on the surfaces of CDs can selectively interact with Cu 2+ . The formed cupric amine complexes induce significant fluorescence quenching. The "on−off" switching can be further adjusted to the fluorescence "on" mode by the introduction of glutathione (GSH), which hinders the interactions between CDs and Cu 2+ . Based on the fantastic optical behavior of CDs, highly sensitive detection of Cu 2+ and GSH can be achieved. Intracellular imaging of the two targets is also validated.

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Carbon dots with two-photon fluorescence imaging for efficient synergistic trimodal therapy

Cited by 13 publications

References 34 publications

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Carbonized Polymer Dots with Aggregation-Induced Effect for Type I Photodynamic Therapy

Bright Green-Emissive Carbon Nanodots for Sensing and Intracellular Imaging of Cu²⁺ and Glutathione

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Carbon dots with two-photon fluorescence imaging for efficient synergistic trimodal therapy

Cited by 13 publications

References 34 publications

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Carbonized Polymer Dots with Aggregation-Induced Effect for Type I Photodynamic Therapy

Bright Green-Emissive Carbon Nanodots for Sensing and Intracellular Imaging of Cu2+ and Glutathione

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Product

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Bright Green-Emissive Carbon Nanodots for Sensing and Intracellular Imaging of Cu²⁺ and Glutathione