Carbon dots for in vivo fluorescence imaging of adipose tissue-derived mesenchymal stromal cells

The Differential Effect of Carbon Dots on Gene Expression and DNA Methylation of Human Embryonic Lung Fibroblasts as a Function of Surface Charge and Dose

“…In mouse fibroblasts NIH/3T3 exposed to pCD, the viability detected using the MTT assay was not affected after treatment with concentrations relevant for cell imaging [15]. Malina et al [16] exposed human mesenchymal stromal cells to pCD. By the detection of ROS generation, analyses of cell viability, cell cycle changes, and DNA fragmentation by comet assay, they discovered that these carbon nanoparticles are biocompatible, even at a very high dose (400 µg/mL) and did not cause a negative effect on the behavior or native function of the cells at a dose of 100 µg/mL.…”

“…For the first time, Datta et al [15] imported these CDs in the cell nucleus of mouse fibroblasts (NIH/3T3) and showed no cell viability changes after using the concentration necessary for cell imaging. Malina et al [16] used pCDs as a novel stem cell tracking probe in in vivo experiments with transplanted human mesenchymal stromal cells. They described high biocompatibility by studying in vitro toxicity.…”

“…They described high biocompatibility by studying in vitro toxicity. Based on the results of ROS production, cell viability, cell cycle changes, and DNA breaks assessed by comet assay, pCDs in concentration applicable for imaging, have not been found to cause any negative effects on the native function and behavior of the stromal cells [16].…”

Self‐Quenching‐Resistant Red Emissive Carbon Dots with High Stability for Warm White Light‐Emitting Diodes with a High Color Rendering Index

“…Carbon dots (CDs), an emerging class of carbon‐based luminescent nanomaterials, have attracted more and more attention and interest in recent years owing to their outstanding properties, such as chemical stability, [ 10,11 ] photostability, [ 12–14 ] biocompatibility, [ 15,16 ] and low toxicity. [ 17–19 ] Because of those distinct merits, CDs could be able to apply in extensive fields, such as drug delivery, [ 20,21 ] solar cell, [ 22 ] optoelectronic devices, [ 23,24 ] bioimaging, [ 25,26 ] and so on.…”

Sensible graphene oxide differentiates macrophages and Leishmania: a bio-nano interplay in attenuating intracellular parasite

“…14 The drug-delivery efficiency of the nanocarriers has demonstrated a large dependence on the surface charge, and it is predominantly believed that a positive surface charge could increase the uptake and toxicity. [15][16][17][18] Hence to avoid such nonspecic binding, a smart system having a negative charge but which could attain a positive charge in the targeted cell environment is desired. To achieve this, a nanogel with 2-diisopropylamino, which can turn negatively to positively charged in the acidic environment at the extracellular tumour cell space has been previously demonstrated.…”