Carbon dots embedded metal organic framework @ chitosan core-shell nanoparticles for vitro dual mode imaging and pH-responsive drug delivery

Lin, Caixue; Sun, Keke; Zhang, Cheng; Tan, Tingyuan; Xu, Mingyue; Liu, Yana; Xu, Chen; Wang, Yingxi; Li, Ling; Whittaker, Andrew K.

doi:10.1016/j.micromeso.2019.109775

Cited by 47 publications

(24 citation statements)

References 30 publications

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“…To demonstrate their optical imaging properties, Lin et al [141] encapsulated CQDs into novel core-shell Metal Organic Frameworks (MOFs). The composite was further coated with O-carboxymethyl chitosan (OCMC) to form OCMC/MOFs/CQDs to improve biocompatibility and endow pH-responsive property.…”

Section: Carbon Quantum Dots (Cqds)mentioning

confidence: 99%

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Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

239

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Section: Carbon Quantum Dots (Cqds)mentioning

confidence: 99%

“…Figure22. Schematic illustrated the preparation of the MOFs/CDs/OCMC nanocomposites and their application as drug carriers of DOX for the treatment of cancer[141]. Reproduced with permission from Elsevier (Copyright©2020).…”

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confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

239

120

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“…MOFs are among the most promising classes of materials for bioapplications reported within the past two decades. Some of these solids are biodegradable and biocompatible, with a structure and composition that can be easily tuned to optimize the loading capacities (drugs, gases) and release properties to meet the requirements for drug delivery systems (DDS), 18,19 imaging, [19][20][21][22] sensing [23][24][25][26][27][28] and tissue engineering.…”

Section: Advantages Of Mofs In Biomedical Applicationsmentioning

confidence: 99%

Metal–organic frameworks towards bio-medical applications

Lepoitevin

Serre

2021

Mater. Chem. Front.

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“…Li and co‐workers encapsulated fluorescent carbon dots (CDs) into MIL100 (Fe‐BTC) to realize FOI/MRI dual‐mode imaging for the first time. [ 56 ] MIL 100 was a kind of non‐toxic iron(iii) carboxylate MOFs, which have good biocompatibility, degradability and imaging function. [ 57 ] MOFs/CDs@OCMC particles were highly biocompatible and suitable to be used to transport drugs in human bodies.…”

Section: Mofs For Fluorescence Imaging In Living Cellsmentioning

confidence: 99%

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo^†

et al. 2021

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Metal‐organic frameworks (MOFs) as a class of porous functional materials have attracted more and more attention for biomedical applications. To date, MOFs have been developed for bioimaging based on a series of advantages such as the large surface areas, high porosity, fluorescence functionalities and good biocompatibility. It is worth noting that organic or inorganic fluorescent materials such as fluorescent dyes, quantum dots, metal nanoclusters and nanosheets can combine MOFs or be encapsulated in MOFs to form fluorescent nanocomposites for excellent imaging function. Importantly, excellent imaging capabilities are of great significance in living cells and in vivo for detection, diagnosis and cancer therapy. In this review, we focus on the recent research of the bioimaging in living cells and in vivo based on various MOF‐based nanocomposites and their potential biological clinical applications.

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Carbon dots embedded metal organic framework @ chitosan core-shell nanoparticles for vitro dual mode imaging and pH-responsive drug delivery

Cited by 47 publications

References 30 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Metal–organic frameworks towards bio-medical applications

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo^†

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Carbon dots embedded metal organic framework @ chitosan core-shell nanoparticles for vitro dual mode imaging and pH-responsive drug delivery

Cited by 47 publications

References 30 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Metal–organic frameworks towards bio-medical applications

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo†

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Product

Resources

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Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo^†