Carbon dots doped with nitrogen and sulfur and loaded with copper(II) as a “turn-on” fluorescent probe for cystein, glutathione and homocysteine

Guo, Ying; Yang, Lianli; Li, Wu-Wu; Wang, Xiaofang; Shang, Yonghui; Li, Baoxin

doi:10.1007/s00604-016-1779-6

Cited by 112 publications

(35 citation statements)

References 35 publications

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“…The N,S-CDs probe was successful in the selective detection of biothiols in human serum but so far lacks selectivity for each of GSH/Cys/Hcy. [15t] …”

Section: Nanoprobes As Materials For the Potential Discrimination Of mentioning

confidence: 99%

“…[14] There have been a large number of fluorescent probes for biothiols reported in just the past decade. Most can be divided into three categories based on function: 1) The detection of GSH/Cys/Hcy (universal thiol probes) over other amino acids, [15] 2) the selective detection one or two of GSH/Cys/Hcy (Table 1), and 2) simultaneous discrimination of Cys, Hcy, and GSH. This purpose of this Minireview is two-fold.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH

et al. 2017

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Biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) play crucial roles in maintaining redox homeostasis in biological systems. This Minireview summarizes the most significant current challenges in the field of thiol-reactive probes for biomedical research and diagnostics, emphasizing the needs and opportunities that have been under-investigated by chemists in the selective probe and sensor field. Progress on multiple binding site probes to distinguish Cys, Hcy, and GSH is highlighted as a creative new direction in the field that can enable simultaneous, accurate ratiometric monitoring. New probe design strategies and researcher priorities can better help address current challenges, including the monitoring of disease states such as autism and chronic diseases involving oxidative stress that are characterized by divergent levels of GSH, Cys, and Hcy.

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“…The N,S-CDs probe was successful in the selective detection of biothiols in human serum but so far lacks selectivity for each of GSH/Cys/Hcy. [15t] …”

Section: Nanoprobes As Materials For the Potential Discrimination Of mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH

et al. 2017

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“…For instance, one of the major limitations of single-element-doped C-dots is that their light emission spectra are confined to the blue-yellow range. 139 Several researchers suggested that such disadvantages of singleelement doping can be overcome by doping two or more atoms simultaneously, which is called co-doping. 39,106,135, Please do not adjust margins…”

Section: Co-dopingmentioning

confidence: 99%

Improving the functionality of carbon nanodots: doping and surface functionalization

et al. 2016

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Distinct from conventional carbon nanostructures, such as fullerene, graphene, and carbon nanotubes, carbon nanodots (C-dots) exhibit unique properties such as strong fluorescence, high photostability, chemical inertness, low toxicity, and biocompatibility. Various synthetic routes for C-dots have been developed in the last few years, and now intense research efforts have been focused on improving their functionality. In this aspect, doping and surface functionalization are two major ways to control the chemical, optical, and electrical properties of C-dots. Doping introduces atomic impurities into C-dots to modulate their electronic structure, and surface functionalization modifies the C-dot surface with functional molecules or polymers. In this review, we summarize recent progress in doping and surface functionalization of C-dots for improving their functionality, and offer insight into controlling the properties of C-dots for a variety of applications ranging from biomedicine to optoelectronics to energy.

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“…Dabei löscht das Metall die N,S‐CD‐Fluoreszenz, und die biologischen Thiole stellen diese wieder her. Die N,S‐CD‐Sonde wurde erfolgreich bei der selektiven Bestimmung biologischer Thiole in humanem Serum eingesetzt, kann aber bisher nicht zwischen GSH/Cys/Hcy unterscheiden …”

Section: Nanomaterialien Als Potenzielle Sonden Zur Unterscheidung Vounclassified

Fluoreszenzsonden mit mehreren Bindungsstellen unterscheiden zwischen Cys, Hcy und GSH

et al. 2017

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Thiole wie Cystein (Cys), Homocystein (Hcy) und Glutathion (GSH) spielen für das Redoxgleichgewicht in biologischen Systemen eine entscheidende Rolle. Dieser Kurzaufsatz fasst aktuelle Aspekte aus dem Bereich der reaktiven Thiolsonden für die biomedizinische Forschung und Diagnostik zusammen und betont die verbleibenden Herausforderungen für Chemiker im Bereich der selektiven Sonden und Sensoren. Der Fortschritt bei Sonden mit mehreren Bindungsstellen stellt eine kreative neue Richtung des Feldes dar, die gleichzeitige und akkurate ratiometrische Messungen ermöglichen kann. Neue Strategien zur Entwicklung von Sonden können helfen, aktuelle Aufgaben anzugehen. Dazu zählt das Monitoring von Krankheiten, die durch abweichende GSH‐, Cys‐ und Hcy‐Spiegel gekennzeichnet sind, wie etwa Autismus und chronische Erkrankungen, die auf oxidativem Stress beruhen.

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Carbon dots doped with nitrogen and sulfur and loaded with copper(II) as a “turn-on” fluorescent probe for cystein, glutathione and homocysteine

Cited by 112 publications

References 35 publications

Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH

Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH

Improving the functionality of carbon nanodots: doping and surface functionalization

Fluoreszenzsonden mit mehreren Bindungsstellen unterscheiden zwischen Cys, Hcy und GSH

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