Carbon Dots as a New Class of Diamagnetic Chemical Exchange Saturation Transfer (diaCEST) MRI Contrast Agents

Zhang, Jia; Yuan, Yue; Gao, Minling; Zheng, Han; Chu, Chengyan; Li, Yuguo; Zijl, Peter C.M. van; Ying, Mingyao; Bulte, Jeff W.M.; Liu, Guanshu

doi:10.1002/anie.201904722

Cited by 48 publications

(19 citation statements)

References 56 publications

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“…Carbon dots (CDs), with good biocompatibility, low cost, and simple synthesis procedure, − have been used as a versatile class of nanomaterials for fluorescence bioanalysis, photocatalysis, and optoelectronic devices. − As well known, some CDs staining mitochondria or the nucleolus have been reported. , For example, Wei et al prepared the nitrogen and sulfur co-doped carbon nanodots that can target mitochondria and enhance intracellular reactive oxygen species (ROS) . Wu’s group produced the red emissive CDs with nucleolus-targeting ability for cell and in vivo imaging .…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Carbon Dots Shuttling between Mitochondria and the Nucleolus for in Situ Visualization of Cell Viability

Guo

Sun

et al. 2020

ACS Appl. Bio Mater.

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Monitoring cell viability plays a vital role in fundamental aspects of pathology, medicine, and biology. Mitochondria and the nucleolus are involved in regulating cell viability in many biological processes, such as mitochondrial autophagy, apoptosis, and cell growth. Thus, exploring the variational cell viability reflecting with mitochondria and the nucleolus is very significant and highly required. Herein, in this work, a kind of fluorescent carbon dots (CDs) capable of shuttling between mitochondria and the nucleolus was synthesized through a simple microwave-assisted strategy and utilized for in situ visualization of cell viability. Meanwhile, hydrogen peroxide (H2O2)-induced cell damage and ascorbic acid-mediated cell protective effects were successfully visualized. Moreover, these CDs demonstrate an intrinsic character of wash-free imaging that makes them preferable for the monitoring of cell viability. We believe that the developed CDs have a great potential to be used as a robust tool to facilitate the progress in cell viability-related medicine, biology, and pathology studies.

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Section: Introductionmentioning

confidence: 99%

Fluorescent Carbon Dots Shuttling between Mitochondria and the Nucleolus for in Situ Visualization of Cell Viability

Guo

Sun

et al. 2020

ACS Appl. Bio Mater.

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“…The XPS spectra of C-CDs showed three typical peaks of C 1s (at around 284.6 eV), N 1s (at around 397.9 eV), and O 1s (at around 531.6 eV). The deconvolutions of the C 1s reveal the presence of four carbon species of C–C (284.2 eV), C–N (285.7 eV), C–O (286.8 eV), and CO (288.2 eV). − The N 1s spectra can be deconvolved into three components attributed to C–N (399.5 eV), OC–N (401.4 eV), and N–H (402.3 eV), and the O 1s peak consists of three components corresponding to CO (531.5 eV), OC–N (531.7 eV), and OC–OH (532.2 eV). ,− …”

Section: Resultsmentioning

confidence: 98%

Cross-Linked Polyamide Chains Enhanced the Fluorescence of Polymer Carbon Dots

Yang¹,

Zhang²,

Xue

et al. 2020

ACS Omega

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Carbon dots (CDs) have attracted tremendous attention for their outstanding advantages in luminescence. Here, α-amino-substituted lysine derivatives with the determined chemical structure were employed as precursors to obtain bright and highly stable fluorescent CDs through a facile hydrothermal route. The relationships among the chemical structure of precursors, CD fluorescence, and particle size were investigated. The results indicated that increased numbers of functional groups in precursors could promote the degree of cross-linking and lead to a smaller size, better fluorescent properties, and stronger stability of CDs. The C-CDs that were prepared from lysine derivatives with most functional groups showed excitation-dependent dual excitation and dual emission (DE2), high-stability luminescence, strong resistance to photobleaching, and high selectivity to Fe3+ and could be used as a sensitive probe for Fe3+ detection.

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“…Fluorescent dots were found to dissociate within lysosomes after endocytic uptake and activate cellular apoptosis, triggering a cytotoxic effect in U-87 MG GBM cells [ 195 ]. Similarly, CNDQs were observed to distribute to lysosomes 6 h after incubation and also selectively target pediatric GBM cells, without affecting normal human embryonic kidney (HEK293) cells after conjugation with transferrin protein [ 196 , 197 , 198 ]. Interestingly, CNQDs prepared from spices (red chili, black pepper, cinnamon, turmeric) displayed higher uptake and toxicity in LN-229 GBM cells than normal human kidney cells [ 199 ].…”

Section: Metal-based Nanoparticlesmentioning

confidence: 99%

Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update

2022

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Glioblastoma (GBM) is the most commonly diagnosed and most lethal primary malignant brain tumor in adults. Standard treatments are ineffective, and despite promising results obtained in early phases of experimental clinical trials, the prognosis of GBM remains unfavorable. Therefore, there is need for exploration and development of innovative methods that aim to establish new therapies or increase the effectiveness of existing therapies. One of the most exciting new strategies enabling combinatory treatment is the usage of nanocarriers loaded with chemotherapeutics and/or other anticancer compounds. Nanocarriers exhibit unique properties in antitumor therapy, as they allow highly efficient drug transport into cells and sustained intracellular accumulation of the delivered cargo. They can be infused into and are retained by GBM tumors, and potentially can bypass the blood–brain barrier. One of the most promising and extensively studied groups of nanostructured therapeutics are metal-based nanoparticles. These theranostic nanocarriers demonstrate relatively low toxicity, thus they might be applied for both diagnosis and therapy. In this article, we provide an update on metal-based nanostructured constructs in the treatment of GBM. We focus on the interaction of metal nanoparticles with various forms of electromagnetic radiation for use in photothermal, photodynamic, magnetic hyperthermia and ionizing radiation sensitization applications.

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Carbon Dots as a New Class of Diamagnetic Chemical Exchange Saturation Transfer (diaCEST) MRI Contrast Agents

Cited by 48 publications

References 56 publications

Fluorescent Carbon Dots Shuttling between Mitochondria and the Nucleolus for in Situ Visualization of Cell Viability

Fluorescent Carbon Dots Shuttling between Mitochondria and the Nucleolus for in Situ Visualization of Cell Viability

Cross-Linked Polyamide Chains Enhanced the Fluorescence of Polymer Carbon Dots

Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update

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