Carbon disulfide: A semiochemical mediating socially-induced diet choice in rats

Galef, Bennett G.; Mason, J. Russell; Preti, George; Bean, N. Jay

doi:10.1016/0031-9384(88)90285-5

Cited by 213 publications

(163 citation statements)

References 9 publications

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“…Galef et al (1988) have shown that smelling the food odor in combination with the breath of the demonstrator is essential for acquiring the preference for the demonstrated food, and this requires sniffing of the mouth area. In this experiment, there were no meaningful effects of PPT on the amount of oronasal investigation, and thus the inhibitory effects of PPT on social learning cannot be explained by an effect on this behavior.…”

Section: Effects Of Pptmentioning

confidence: 99%

“…In the socially transmitted food preference (STFP) paradigm, an 'observer' will acquire a food preference from a brief interaction with a recently fed 'demonstrator' (Galef and Wigmore, 1983). The STFP was initially described in rats (eg Galef and Wigmore, 1983;Galef et al, 1988), and has been subsequently found in several rodent species, including house mice (Mus musculus; Valsecchi and Galef, 1989). In mice, like rats, the food odor must be carried in the mouth of a live conspecific for the observer to learn the preference (Valsecchi and Galef, 1989).…”

Section: Introductionmentioning

confidence: 99%

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Differential Effects of Estrogen Receptor Alpha and Beta Specific Agonists on Social Learning of Food Preferences in Female Mice

Clipperton

Spinato

Chernets

et al. 2007

Neuropsychopharmacol

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There is an evolutionary advantage to learning food preferences from conspecifics, as social learning allows an individual to bypass the risks associated with trial and error individual learning. The social transmission of food preferences (STFP) paradigm examines this advantage. Females in the proestrus and diestrus phases of the estrous cycle show a prolonged preference for the demonstrated food relative to estrus and ovariectomized females. Additionally, both estrogen receptor alpha (ERa) and estrogen receptor beta (ERb) knockout mice show impaired social recognition, which suggests that both receptors may be involved in other types of socially dependent learning, including the STFP. The present study investigated the effect of the ERa selective agonist PPT (1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole) and the ERb selective agonist WAY-200070 (7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol) on the STFP. Results showed that ovariectomized (ovx) mice treated with PPT failed to learn the socially acquired preference, while WAY-200070-treated ovx mice showed a two-fold prolonged preference for the food eaten by their demonstrator. The effects of PPT on the socially acquired food preference cannot be explained by effects on the total food intake of the groups or on the type of interaction with the demonstrator mouse. The effects of WAY-200070 may be partially due to effects on Submissive Behavior. The higher WAY-200070 doses produced prolonged preferences similar to those seen previously in intact female mice during the proestrus and diestrus phases. This suggests that the estrous cycle's effects on social learning may be due to the action of ERb on Submissive Behavior, or to ERb countering that of ERa.

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Section: Effects Of Pptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differential Effects of Estrogen Receptor Alpha and Beta Specific Agonists on Social Learning of Food Preferences in Female Mice

Clipperton

Spinato

Chernets

et al. 2007

Neuropsychopharmacol

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“…When the second (or third) cagemate was tested, it was prevented from contacting the first cagemate before participating in the test, to avoid social facilitation through smelling the novel food on its cagemate's breath (Galef, Mason, Preti, & Bean, 1988). Between tests the bowl was cleaned with a damp tissue and a dry one, and any remaining sweetcorn was replaced with fresh kernels, again to avoid the influences of any odor deposits from previous rats.…”

Section: Author Proofmentioning

confidence: 99%

Marked for life? Effects of early cage‐cleaning frequency, delivery batch, and identification tail‐marking on rat anxiety profiles

Burn

Deacon

Mason

2008

Developmental Psychobiology

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Daily handling of preweanling rats reduces their adult anxiety. Even routine cage-cleaning, involving handling, reduces adult anxiety compared with controls. Cage-cleaning regimes differ between animal breeders, potentially affecting rodent anxiety and experimental results. Here, 92 adult male rats given different cage-cleaning rates as pups, were compared on plus-maze, hyponeophagia, corticosterone, and handling tests. They were pair-housed and half were tailmarked for identification. Anxiety/stress profiles were unaffected by cage-cleaning frequency, suggesting that commercial-typical differences in husbandry contribute little variance to adult rat behavior. However, delivery batch affected some elevated plus-maze measures. Also, tail-marked rats spent three times longer on the plusmaze open arms than their unmarked cagemates, suggesting reduced anxiety, yet paradoxically they showed greater chromodacryorrhoea responses to handling, implying increased aversion to human contact. A follow-up study showed that rats avoided the odor released from the marker pen used. Thus, apparently trivial aspects of procedure can greatly affect experimental results.

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“…Consequently, when the chemical contents of a sample of air taken from the nose of a rat and the chemical contents of a sample of air taken from the mouth of that rat are compared, any differences between the two samples should reveal the chemical components of rat breath. Results of mass spectrometry carried out in collaboration with the Monell Chemical Senses Center revealed carbon disulfide and carbonyl sulfide as important components of rat breath (Galef, Mason, Preti, & Bean, 1988). As can be seen in Figure 10, adding a few drops of a dilute solution of carbon disulfide (a compound found in rat breath) to a surrogate rat powdered with food made that piece of cotton batting almost as effective as an anesthetized demonstrator rat in altering observers' food preferences.…”

Section: Social Influences On the Food Choices Of Norway Ratsmentioning

confidence: 99%

“…Third, while eating, adult rats mark both foods and feeding sites they exploit with residual chemical cues, and marked foods and feeding sites are far more attractive to juveniles than are unmarked sites or foods (Galef & Beck, 1985;Galef & Heiber, 1976;Galef & Muskus, 1979). Fourth, adult rats lay scent trails as they travel from a feeding site back to their burrow, and juveniles follow trails adults have created leading to food (Galef & Buckley, 1996).…”

Section: Social Influences On the Food Choices Of Norway Ratsmentioning

confidence: 99%

Social influences on food choices of Norway rats and mate choices of Japanese quail

Galef

2002

Appetite

Self Cite

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Here I review the two major lines of research in which my laboratory has been engaged for the past 35 years. The first of these research programs concerns the description and analysis of social learning processes influencing food choices of Norway rats (Rattus norvegicus). The second involves social interactions affecting mate choices of Japanese quail (Coturnix japonica). Study of these model systems has shown that at least two biologically important behaviors, food choice and mate choice, can be shaped by social interactions and that the social interactions that bias behavioral development are open to reductionist analysis in terms of the behavior of interacting individuals.

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Carbon disulfide: A semiochemical mediating socially-induced diet choice in rats

Cited by 213 publications

References 9 publications

Differential Effects of Estrogen Receptor Alpha and Beta Specific Agonists on Social Learning of Food Preferences in Female Mice

Differential Effects of Estrogen Receptor Alpha and Beta Specific Agonists on Social Learning of Food Preferences in Female Mice

Marked for life? Effects of early cage‐cleaning frequency, delivery batch, and identification tail‐marking on rat anxiety profiles

Social influences on food choices of Norway rats and mate choices of Japanese quail

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