Carbon dioxide transport

Arthurs, Graham; Sudhakar, M.

doi:10.1093/bjaceaccp/mki050

Cited by 158 publications

(59 citation statements)

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“…1). Given a solubility constant of 0Á0308 for CO 2 in blood at 37°C [41], the change in CO 2 concentration is roughly 0Á93 mM which is the same order of magnitude as measured internal citrate and malate concentrations. In a previous study of AS-3 where RBC units were sampled pre-, during, and postleucoreduction and prior to day 1, high intracellular citrate levels were detected immediately following blood collection and dropped during storage [12].…”

Section: Discussionmentioning

confidence: 69%

Metabolomics comparison of red cells stored in four additive solutions reveals differences in citrate anticoagulant permeability and metabolism

et al. 2017

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Section: Discussionmentioning

confidence: 69%

Metabolomics comparison of red cells stored in four additive solutions reveals differences in citrate anticoagulant permeability and metabolism

et al. 2017

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“…readily measurable. An equilibrium exists and the covalent N-C bond is rapidly reversible in the presence of oxygen, among others [17]. However, the amount of carbon dioxide held in blood in the carbamino form is small [17] and the sum of dissolved CO 2 plus bicarbonate nearly stands for the total content of carbon dioxide.…”

Section: Discussionmentioning

confidence: 99%

Novel CO2 removal device driven by a renal-replacement system without hemofilter. A first step experimental validation

Godet

Combes

Zogheib

et al. 2015

Anaesthesia Critical Care & Pain Medicine

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“…Molar concentrations for oxygen and carbon dioxide were calculated for the inlet region:

{c false({normalO}_{2} false)}_{normalI normaln normall normale normalt} = {p normalO}_{2, normalI normaln normall normale normalt} \cdot α_{{normalO}_{2}}

{c false({normalC normalO}_{2} false)}_{normalI normaln normall normale normalt} = {p normalC normalO}_{2, normalI normaln normall normale normalt} \cdot α_{normalC {normalO}_{2}}

where

α_{{normalO}_{2}}

is the solubility for oxygen in blood with a value of 0.00156 (mol mm Hg −1 m 3 ) and

α_{normalC {normalO}_{2}}

is the solubility for carbon dioxide in blood with a value of 0.0308 (mol mm Hg −1 m 3 ) .…”

Section: Methodsmentioning

confidence: 99%

Computational Modeling of Oxygen Transfer in Artificial Lungs

et al. 2018

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Under physiological conditions, up to 97% of the oxygen in blood that is transported from lungs to tissue is bound to hemoglobin. To predict oxygen transfer in artificial lungs on a membrane fiber level with computational fluid dynamics (CFD), previous investigators have incorporated the hemoglobin-oxygen interaction into an effective diffusivity coefficient to modify the convection-diffusion equation. Based on our own simulations and experiments, these approaches tend to significantly overestimate the oxygen transfer. The present study introduces a novel approach to model the oxygen transfer in blood on a fiber level with CFD. Plasma and red blood cells were implemented as two phases and the reaction of hemoglobin and oxygen to oxyhemoglobin was included in the convection-diffusion equation in form of a source term. The model was implemented with the commercial software Ansys CFX 18.1. CFD simulations were compared with in vitro experiments on three micro oxygenators with a staggered fiber configuration under multiple blood flow conditions. To calibrate the model, a reaction rate R was introduced and experimental data was fitted to a blood flow of 50 mL/h. Our model approximated the oxygen transfer rates with a difference, relative to in vitro results, of -23.7 and +6.3% for blood flows of 20 and 90 mL/h, respectively. The effective diffusivity model, used by previous authors, was implemented for comparison and approximated oxygen transfer rates with a difference, relative to in vitro data, of +13.7, +68.8, and +121.0% for blood flows of 20, 50, and 90 mL/h, respectively. A well-established numerical mass transfer correlation approximated the gas transfer with a difference, referenced on the average in vitro data, of 31.8, 13.1, and 5.0% for blood flows of 20, 50, and 90 mL/h, respectively. Even though results are promising, a thorough validation of the model will require extensive CFD and in vitro studies of multiple fiber arrangements, fiber diameters, and therefore fiber bundle porosities in the future. This article should be understood as a first feasibility study to evaluate the potential of the novel oxygen transfer model.

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Carbon dioxide transport

Cited by 158 publications

References 1 publication

Metabolomics comparison of red cells stored in four additive solutions reveals differences in citrate anticoagulant permeability and metabolism

Metabolomics comparison of red cells stored in four additive solutions reveals differences in citrate anticoagulant permeability and metabolism

Novel CO2 removal device driven by a renal-replacement system without hemofilter. A first step experimental validation

Computational Modeling of Oxygen Transfer in Artificial Lungs

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