Carbon dioxide laser photoablation adjunctive therapy following superficial lamellar keratectomy and bulbar conjunctivectomy for the treatment of corneolimbal squamous cell carcinoma in horses: a review of 24 cases

Abstract

As an adjunctive therapy, CO(2) photoablation was successful in 87.5% of the horses following a single procedure and in a total of 91.7% following a second therapeutic application. CO(2) photoablation appears to be effective as an adjunctive therapy following removal of large corneolimbal SCC in the horse and in cases in which all tumor cells were not excised.

Equine ocular squamous cell carcinoma: a case report

“…In numerous publications, recurrences have not been reported doi: 10.17221/8386-VETMED in surrounding tissues after enucleation (Beard and Wilkie 2002;Mosunic et al 2004;Bosch and Klein 2005;Kafranik et al 2009;Michau et al 2012;Albanese et al 2014).…”

“…Adjunctive treatment may involve cryotherapy (Schoster 1992;Bosh and Klein 2005), radiofrequency hyperthermia (Wilkie and Burt 1990), photodynamic therapy (English et al 1990;Guiliano et al 2008;Michau et al 2012), immunotherapy (McCalla et al 1992), chemotherapy with cisplatin (Theon et al 1993), 5-fluorouracyl (Pucket and Gilmour 2014) or mitomycin C (Clode et al 2012), radiotherapy such as brachytherapy (King et al 1991), interstitial therapy (Chachory et al 2002), and beta radiation (Walker et al 1986;Rebhun 1990;Plummer et al 2007).…”

“…The disease mainly affects horses eight to 13 years old (Gelatt et al 1974;Schwink 1987;Mosunic et al 2004;Michau et al 2012;Lassaline et al 2014). A more frequent incidence of the neoplasm has been reported in equine breeds with a grey hair coat component than in dark-pigmented horses (Gelatt et al 1974;Lavach and Severin 1977;Dugan et al 1991a).…”

“…The recurrence rate ranges from 11.1% to 66.7% and is associated with factors such as the type of applied treatment (King et al 1991;Mosunic et al 2004;Michau et al 2012). In addition, recurrences are more common in OSCC affecting the eyelids than in the corneal form of the tumour (Dugan et al 1991b;King et al 1991).…”

“…SCCs of the cornea may be primary when only the corneal cells are involved (Kafarnik et al 2009) or secondary such as a corneolimbal form, when the limbus is primarily infiltrated followed by the cornea (Michau et al 2012;Scurrell et al 2013). Corneal SCC (CSCC) may affect the corneal epithelium (Rebhun 1990), epithelium and stroma (van der Woerdt et al 1996) or the stroma alone as a corneal stromal invasive SCC (Kafranik et al 2009).…”