Carbon dioxide laser for removal of multiple cutaneous neurofibromas

Moreno, J.C.; Mathoret, C; Lantieri, Laurent; Zeller, J; Revuz, J; Wolkenstein, Pierre

doi:10.1046/j.1365-2133.2001.04214.x

Cited by 30 publications

(18 citation statements)

References 5 publications

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“…The disadvantages are a longer procedure time and higher risk of bleeding [6]. CO 2 laser treatment is suitable for removing large numbers of neurofibromas in a short time with good cosmetic outcomes and a low complication rate [2, 8]. The current study confirmed that CO 2 laser treatment under general anesthetic for hundreds of small-to-medium-sized cutaneous neurofibromas has a high patient satisfaction and recommendation rate.…”

Section: Discussionsupporting

confidence: 65%

Carbon Dioxide Laser Treatment of Cutaneous Neurofibromas

Chiang

Al‐Niaimi

Ferguson

et al. 2012

Dermatol Ther (Heidelb)

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IntroductionNeurofibromatosis type 1 (NF1) is an autosomal dominant disorder, with multisystem involvement, including cutaneous manifestations of hyperpigmentation and neurofibromas. Multiple cutaneous lesions are often disfiguring and lead to emotional distress and social isolation. Treatment of NF1 is predominantly surgical but alternative treatments should be considered for patients with large numbers of lesions as cold steel excision of multiple lesions can be cumbersome and may not be practical. The authors report a series of patients with multiple neurofibromas successfully treated using a CO2 laser.MethodsData on CO2 laser treatments, follow-up, and recurrence following treatment was collected retrospectively. A post-treatment telephone survey was carried out to assess patient satisfaction using a standardized set of questions and a scoring tool.ResultsFive of seven patients who underwent CO2 laser treatment of their multiple neurofibromas responded to the post-treatment survey. All five patients (age range 36–56 years, mean age 45.2 years, three men:two women) had multiple variable-sized neurofibromas. The mean number of lesions per patient was 114 (range 20–200 lesions). The mean number of treatment sessions was 2.2 (range 1–4 sessions) and mean follow-up was 14.4 months (range 6–24 months). Three patients (60%) reported no recurrence up to 2 years post-laser treatment. Two patients (40%) had recurrences of a few lesions (≤10% of treated lesions per patient). The mean patient satisfaction score was 9.2 out of 10 (range 8–10). All patients mentioned that they would recommend CO2 laser treatment to others with multiple neurofibromas. Hypopigmentation or depigmentation at treatment sites were the only reported adverse effects.ConclusionBased on current results, the authors feel that CO2 laser treatment achieves a high level of patient satisfaction with a low recurrence of treated lesions.

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Section: Discussionsupporting

confidence: 65%

Carbon Dioxide Laser Treatment of Cutaneous Neurofibromas

Chiang

Al‐Niaimi

Ferguson

et al. 2012

Dermatol Ther (Heidelb)

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“…In parallel, the laser treatment should be tested, systematically, on a few lesions before carrying out extensive treatment. An early study of 11 patients [14] revealed that CO 2 laser ablation was quicker than conventional surgery, with no need for sutures and more acceptable scars than were obtained by surgical excision, for cutaneous neurofibromas <1 cm in diameter.…”

Section: Discussionmentioning

confidence: 99%

“…NF1 has been established as an indication for this treatment for more than 20 years. It was initially performed for cutaneous neurofibromas <1 cm in diameter [14]. In our department, the indications for this treatment now include all cutaneous neurofibromas and dermohypodermal neurofibromas (<3 cm).…”

Section: Introductionmentioning

confidence: 99%

“…Cutaneous neurofibromas result in dysmorphic features and aesthetic prejudice, leading to considerable stigma [10,11,12] and a significant impact on quality of life [13]. The excision of cutaneous neurofibromas, by surgery or with a carbon dioxide (CO 2 ) laser [14,15,16], could improve aesthetic appearance and self-esteem.…”

Section: Introductionmentioning

confidence: 99%

“…In our department, the indications for this treatment now include all cutaneous neurofibromas and dermohypodermal neurofibromas (<3 cm). This treatment seems to be effective in patients with large numbers of small to medium-sized cutaneous neurofibromas [14,16]. …”

Section: Introductionmentioning

confidence: 99%

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Treatment of Neurofibromas with a Carbon Dioxide Laser: A Retrospective Cross-Sectional Study of 106 Patients

et al. 2015

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Background: Few studies have evaluated the efficacy of carbon dioxide (CO₂) laser ablation for treating neurofibromatosis type 1 (NF1). Objective: To evaluate laser treatment safety and patient satisfaction at the French National Referral Centre for Neurofibromatosis. Methods: Retrospective survey with a specific questionnaire. The principal outcome measures included pain evaluation and assessments of treatment safety. Results: We included 106 patients, 70% of whom had more than 50 neurofibromas. Laser treatment was performed mostly for aesthetic reasons, or due to pain, recurrent local trauma or familial influence, under a local anaesthetic, during outpatient visits. The mean pain score was 4.0 ± 2.7 during the administration of local anaesthesia, 2.4 ± 2.1 during laser treatment and <2 48 h after treatment in 56% of cases. The mean satisfaction score for the treatment was 4.6 ± 3.4 and was not associated with disease phenotype. Conclusions: CO₂ laser treatment for NF could be considered more frequently and might help to decrease the social impact of the disease.

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