Carbon dioxide laser-assisted dermabrasion versus mechanical dermabrasion in the treatment of stable vitiligo

Makki, Mahmoud; Saudi, Wael M.; Hasan, Hafizhah Fakhirah

doi:10.4103/jewd.jewd_22_19

Cited by 3 publications

(18 citation statements)

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“…However, early treatment of segmental vitiligo (duration of less than 1 year) demonstrates more favorable outcome. Darker skin phototypes have superior improvement along with more postinflammatory hyperpigmentation (PIH) rate compared to lighter skin phototypes 2–43 . Combination of laser with other medical modalities leads to faster RR, higher efficacy, lower relapse rate, and better compliance in patients with localized non‐segmental type of vitiligo, though this combination has superior efficacy on both UV‐sensitive and UV‐resistant (acral and bony prominence) areas compared to monotherapy; however, UV‐sensitive areas revealed significantly favorable regimentation rate compared to UV‐resistant areas 2–43 .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, release of growth factors and inflammatory cytokines (interleukin [IL]‐17, matrix metalloproteinase [MMP]‐2, and MMP‐9) during healing process results in proliferation of melanocytes and leads to melanogenesis. On the contrary, skin resurfacing enhances transdermal drug delivery into dermis 27–38 . Combined fractional ablative lasers with other medical modalities are preferable to conventional lasers due to favorable safety profile and outcome 27–43 .…”

Section: Discussionmentioning

confidence: 99%

“…Fractional ablative lasers are preferred to conventional ablative lasers due to favorable safety profile and faster recovery time. [27][28][29][30][31][32][33][34][35][36][37][38] One study demonstrated no significant difference between adding high or low-fluence fractional CO 2 to combined TCS plus NB-UVB. This indicates that only superficial ablation of skin into papillary dermis is sufficient to promote proliferation and migration of melanocytes and enhances penetration of topical drug.…”

Section: Combination Of Arls With Other Medical Treatment Modalitiesmentioning

confidence: 99%

“…36 There were two studies that evaluated efficacy of combined fractional CO 2 with 5-FU. 37,38 The first study compared efficacy of adding fractional CO 2 or dermabrasion to combined 5FU plus MEL.…”

Section: Combination Of Arls With Other Medical Treatment Modalitiesmentioning

confidence: 99%

“…On the contrary, skin resurfacing enhances transdermal drug delivery into dermis. [27][28][29][30][31][32][33][34][35][36][37][38] Combined fractional ablative lasers with other medical modalities are preferable to conventional lasers due to favorable safety profile and outcome. [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] ***Fractional Er:YAG usually have slower response rate with higher safety profile compared to fractional CO 2 laser.…”

Section: Combination Of Nafl With Other Medical Treatment Modalitiesmentioning

confidence: 99%

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Treatment protocols and efficacy of combined laser with medical treatment modalities in vitiligo

Mohammadi

Amiri

Khalili

et al. 2021

J of Cosmetic Dermatology

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Vitiligo is an acquired immune-mediated pigmentary skin disease affecting 1%-2% of worldwide population. 1 First-line therapy for restricted and extensive involvement is topical therapy (corticosteroids [TCS] and calcineurin inhibitors [TCI, tacrolimus, and pimecrolimus]) and narrow-band ultraviolet B (NB-UVB), respectively. 2-5 Nowadays, lasers are used for treatment of difficult-to-treat areas and refractory lesions. Monochromatic excimer laser (MEL)/excimer light (EL) was the first laser used in treatment of vitiligo. Ablative resurfacing

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Combination Of Arls With Other Medical Treatment Modalitiesmentioning

confidence: 99%

Section: Combination Of Arls With Other Medical Treatment Modalitiesmentioning

confidence: 99%

Section: Combination Of Nafl With Other Medical Treatment Modalitiesmentioning

confidence: 99%

See 3 more Smart Citations

Treatment protocols and efficacy of combined laser with medical treatment modalities in vitiligo

Mohammadi

Amiri

Khalili

et al. 2021

J of Cosmetic Dermatology

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Comparing the efficacy of Micro-needling Alone versus Micro-needling with Topical 5-Fluorouracil in Treating Stable Non-Segmental Vitiligo

Khafagy¹,

Hassen²,

Ezat³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Vitiligo is a commonly acquired, idiopathic, heritable white macule which increases in diameter with time due to melanocytes loss. Several treatment modalities, ranging from medical to surgical interference, are available. Many studies stated that inducing injury combined with topical 5Fluoro-uracil (5-FU) induces skin re-pigmentation in vitiligo lesions. Microneedling is a reasonably, inexpensive, easy and fast evaluating tool present in outpatient clinics as a trans-dermal drug delivery device for high molecular-weight drugs to enhance their absorption and effect. Objectives: Evaluation of the efficacy of micro-needling plus topical 5-FU in treating stable non-segmental vitiligo and comparing its results with micro-needling alone. Patients and Methods: Fifty patients complaining of stable, non segmental vitiligo were recruited for our study, where we picked two patches; one patch was treated with micro-needling without adding any medicine, while we treated the other with micro-needling with 5-FU added. The sessions were every 2 weeks, and each patient received 6 sessions in 3 months. Results: On the micro-needling alone side, none (0%) of studied participants showed repigmentation, while in microneedling with 5FU side, 38 (76%) of patients showed repigmentation response, out of which 23 cases (46.0%) had mild repigmentation (<25%) whereas the remaining 15 cases (30.0%) had moderate repigmentation (25-50%). Conclusion: Micro-needling with 5-FU is considered a safe, easy, and tolerable procedure for vitiligo treatment. Significance: Micro-needling and 5 Fluorouracil are well known treatments, used frequently in aesthetic and skin malignancy fields; can be helpful also in pigmentary problems by delivering the drug and creating an inflammatory environment also helping the transportation of melanocytes to the vitiliginous area.

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Problems and prospects in the treatment of various forms of pigmented nevi in children (a literature review)

Podurar,

Gorbatova

2023

Russian Journal of Pediatric Surgery

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Introduction. Pigmented nevi (PN) are formations in the skin layers which consist of accumulated melanocytes of various differentiation degrees and located in different layers of the skin. In modern society, this pathology causes serious medical and psychological problems; not infrequently , one can see unsatisfactory clinical and aesthetic outcomes. There is no any clear tactics which could take into account PN forms, location and child’s age. Purpose. To study modern problems and to outline prospects for treating various PN forms in children using the information obtained after literature search for the period 2005–2022. Material and methods. The authors made the literature search in domestic and foreign databases for the period 2005–2022. The following key words were used for the search: benign melanocytic skin lesions; pigmented nevus; laser radiation. 1627 literature sources were studied, 87 works were included in the review. Results. Despite of various techniques used for PN removal, unsatisfactory results are still noted in 41 % of patients with a complication rate of up to 50 %. After implementation laser scalpel for PN removal, complications in the form of hypertrophic and keloid scars were noted in 2–5 % of patients, postoperative hyperemia- in 21 % of cases, hyperpigmentation in 13 % and hypopigmentation in 34 %. The present review outlines advantages and disadvantages of various modalities used for removing PN. The authors also underline that the most promising ones are laser techniques in which laser light has a specific selectivity to pigmented tissues. The article has no information on parameters of laser irradiation which are required for treating definite forms of PN in children. Conclusion. Further research is needed to optimize existing and to develop new laser light techniques for treating various PN forms which should bring a significant improvement in outcomes.

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Carbon dioxide laser-assisted dermabrasion versus mechanical dermabrasion in the treatment of stable vitiligo

Cited by 3 publications

References 0 publications

Treatment protocols and efficacy of combined laser with medical treatment modalities in vitiligo

Treatment protocols and efficacy of combined laser with medical treatment modalities in vitiligo

Comparing the efficacy of Micro-needling Alone versus Micro-needling with Topical 5-Fluorouracil in Treating Stable Non-Segmental Vitiligo

Problems and prospects in the treatment of various forms of pigmented nevi in children (a literature review)

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