Carbon dioxide laser ablation associated with interferon alfa-2binjections reduces the recurrence of keloids

Conejo‐Mir, Julián; Corbi, Rosa María Lidón; Linares, M. Suárez

doi:10.1016/s0190-9622(98)70295-6

Cited by 47 publications

(13 citation statements)

References 4 publications

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“…The recommendation for postoperative interferon injection is 1,000,000 IU/cm 2 of skin surrounding the postoperative site, administered immediately after surgery and one to two weeks thereafter [50]. In combination with other modalities, such as intralesional triamcinolone acetate and CO 2 lasers, IFN-α2b lowers recurrence rates and leads to good outcomes [35,47]. …”

Section: Methodsmentioning

confidence: 99%

Recent Developments in the Use of Intralesional Injections Keloid Treatment

Perdanasari

Lazzeri

et al. 2014

Arch Plast Surg

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Keloid scars are often considered aesthetically unattractive and frustrating problems that occur following injuries. They cause functional and cosmetic deformities, displeasure, itching, pain, and psychological stress and possibly affect joint movement. The combination of these factors ultimately results in a compromised quality of life and diminished functional performance. Various methods have been implemented to improve keloid scars using both surgical and non-surgical approaches. However, it has proven to be a challenge to identify a universal treatment that can deliver optimal results for all types of scars. Through a PubMed search, we explored most of the literature that is available about the intralesional injection treatment of hypertrophic scars and keloids and highlights both current (corticosteroid, 5-fluorouracil, bleomycin, interferon, cryotherapy and verapamil) and future treatments (interleukin-10 and botulinum toxin type A). The reference lists of retrieved articles were also analysed. Information was gathered about the mechanism of each injection treatment, its benefits and associated adverse reactions, and possible strategies to address adverse reactions to provide reliable guidelines for determining the optimal treatment for particular types of keloid scars. This article will benefit practitioners by outlining evidence-based treatment strategies using intralesional injections for patients with hypertrophic scars and keloids.

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Section: Methodsmentioning

confidence: 99%

Recent Developments in the Use of Intralesional Injections Keloid Treatment

Perdanasari

Lazzeri

et al. 2014

Arch Plast Surg

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“…65 Broker et al observed short-term improvement in 3 of 7 keloids treated with weekly INF-g. 66 Lastly, in an uncontrolled series of 30 patients treated with CO 2 laser excision of keloids and adjuvant intralesional INF-a2b, Conejo-Mir et al found 66% success rate on long-term follow-up. 67 Although some studies have shown keloid remission following intralesional injection of IFN, other data in the literature do not favor IFN alone as a potent treatment approach for keloids and HTS. A prospective-controlled clinical trial by Davison et al investigated the efficacy of IFN-a2b as postexcisional adjuvant therapy for keloids.…”

Section: Interferonmentioning

confidence: 99%

The Emerging Role of Antineoplastic Agents in the Treatment of Keloids and Hypertrophic Scars

Shridharani

Magarakis

Manson

et al. 2010

Annals of Plastic Surgery

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The management of keloids and hypertrophic scars continues to challenge health-care providers. Though both forms of pathologic scarring are distinct entities at the macro and microscopic level, their etiologies and treatment are often similar. Potential treatment approaches are progressing, and combinations of treatment options have been proposed in the literature with promising outcomes. The treatment evolution has reached a level where molecular therapeutic modalities are being investigated. Currently, no gold standard treatment exists. Overall success rates and patient satisfaction seem to be slowly climbing, but additional investigational studies must continue to be performed. Several studies have investigated antineoplastic agents, and there seems to be a marked improvement in rates of recurrence, patient satisfaction, and overall quality of scar when these agents are used. Intralesional injection and/or wound irrigation with interferon-a2b, interferon-g, mitomycin-C, bleomycin, or 5-fluorouracil seems to have a positive effect on the reduction of pathologic scars. There is mounting evidence that these drugs used alone or in combination therapy, have the potential to be an integral part of the treatment paradigm for hypertrophic scars and keloids.

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“…Keloids are notoriously difficult to treat. Many treatments have been proposed, including topical and intralesional steroids, 9,18 lathyrogens, 19 ultraviolet irradiation, 20 intralesional interferon-gamma injections, 21 intralesional 5-fluorouracil, 22 iontophoric tranilast, 23 laser treatment, 9,24 pressure and silicone application, 9 radiation, 9 and surgical excision with or without skin grafting and adjunctive medical/radiation modalities. 9 Success rates using any of these treatments are extremely variable, and none of these treatments has been established as a consistent, reproducible criterion standard for keloids.…”

Section: Treatment Optionsmentioning

confidence: 99%