Carbon–carbon bond formation in acid deep eutectic solvent: chalcones synthesis via Claisen–Schmidt reaction

Abstract

Claisen–Schmidt reaction in acid deep eutectic solvent without the use of acid or basic catalyst.

Assessment of the organocatalytic activity of chiral l-Proline-based Deep Eutectic Solvents based on their structural features

“…In organic synthesis, DESs are finding fruitful applications for the cleanliness, the purity of the obtained products, and the quickness of the developed synthetic procedures. In this field, the role of DESs can be defined as "active" or "innocent" if they participate as reactant or catalyst in the chemical transformation or they just act as green and environmental friendly liquids [30][31][32][33].…”

Deep Eutectic Solvents formed by chiral components as chiral reaction media and studies of their structural properties

“…[26] For these reasons DESs are rapidly increasing their relevance in the green chemistry literature; their application is wide and concerns solvents for organic synthesis, extraction media, media for the synthesis of nanoparticles, electrochemistry, biocatalysys, and so on. [27][28][29][30][31][32][33] DESs represent a novel step forward in the green chemistry, and many topics about these liquids are yet to be explored. The step forward in this topic is represented by the use of smart DESs: solvents that could play an active role (such as a catalytic one) in the reaction or in the process where they are applied.…”

Use of deep eutectic solvents as catalyst: A mini-review

“…The synthesis of chalcones that show significant pharmaceutical properties are under research in terms of green chemistry framework. With this aim, Tiecco et al [68] prepared a DES using 3-(cyclohexyldimethylammonio) propane-1-sulfonate and (1S)-(+)-10-camphorsulfonic acid (SB3-Cy:CSA). They used this Brønsted acid type DES as a catalyst for carbon-carbon bond formation reaction through Claisen-Schmidt condensation and also as a reaction medium.…”

“…Claisen-Schmidt reaction of acetophenones and monoand bi-substituted benzaldehydes catalyzed by DES. g g See Tiecco et al[68] for detailed reaction components and conditions.…”