Carbon beam dosimetry intercomparison at HIMAC

Fukumura, Akifumi; Hiraoka, Takeshi; Omata, Kaname; Takeshita, Mitsue; Kawachi, Kiyomitsu; Kanai, Tatsuaki; Matsufuji, Naruhiro; Tomura, H.; Futami, Yasuyuki; Kaizuka, Yoshihisa; Hartmann, G.

doi:10.1088/0031-9155/43/12/005

Cited by 24 publications

(16 citation statements)

References 8 publications

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“…With the detection efficiency of FNTDs being close to 100 % [6] we found a detection efficiency of about 99 % for the PNTDs for these conditions. The data presented here do thus not support the findings of Fukumura et al [3], namely that the accuracy of PNTDs in the entrance channel of a clinical carbon beam is hampered by incomplete detection of low-LET particles such as fragments. These would have been registered by the FNTDs.…”

Section: Discussioncontrasting

confidence: 99%

Single track coincidence measurements of fluorescent and plastic nuclear track detectors in therapeutic carbon beams

Osinga¹,

Ambrožová²,

Brabcová³

et al. 2014

J. Inst.

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In this paper we present a method for single track coincidence measurements using two different track detector materials. We employed plastic and fluorescent nuclear track detectors (PNTDs and FNTDs) in the entrance channel of a monoenergetic carbon ion beam covering the therapeutically useful energy range from 80 to 425 MeV/u. About 99 % of all primary particle tracks detected by both detectors were successfully matched, while 1 % of the particles were only detected by the FNTDs because of their superior spatial resolution. We conclude that both PNTDs and FNTDs are suitable for clinical carbon beam dosimetry with a detection efficiency of at least 98.82 % and 99.83 % respectively, if irradiations are performed with low fluence in the entrance channel of the ion beam. The investigated method can be adapted to other nuclear track detectors and offers the possibility to characterize new track detector materials against well-known detectors. Further, by combining two detectors with a restricted working range in the presented way a hybrid-detector system can be created with an extended and optimized working range.

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Section: Discussioncontrasting

confidence: 99%

Single track coincidence measurements of fluorescent and plastic nuclear track detectors in therapeutic carbon beams

Osinga¹,

Ambrožová²,

Brabcová³

et al. 2014

J. Inst.

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“…Clinical doses used in both institutions are expressed as gray equivalent. Physical comparison between the two facilities has been done for dose but not for LET distribution yet (9). If biological effectiveness of carbon-ion beams were different between the two facilities, we would have difficulty interpreting clinical results based on clinical dose.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Biological Effectiveness of Carbon-Ion Beams in Japan and Germany

Uzawa¹,

Andō²,

Koike³

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…Details concerning the beam characteristics, biological irradiation procedures and C-ion beam dosimetry have been previously described (29, 30). The experimental dose distributions were measured at the middle of a 6 cm SOBP of C ions, and the energy spread and the dose-average LET values were approximately 0–160 MeV and 50 keV/μm, respectively (7).…”

Section: Methodsmentioning

confidence: 99%

The Major DNA Repair Pathway after Both Proton and Carbon-Ion Radiation is NHEJ, but the HR Pathway is More Relevant in Carbon Ions

et al. 2015

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The purpose of this study was to identify the roles of non-homologous end-joining (NHEJ) or homologous recombination (HR) pathways in repairing DNA double-strand breaks (DSBs) induced by exposure to high-energy protons and carbon ions (C ions) versus gamma rays in Chinese hamster cells. Two Chinese hamster cell lines, ovary AA8 and lung fibroblast V79, as well as various mutant sublines lacking DNA-PKcs (V3), X-ray repair cross-complementing protein-4 [XRCC4 (XR1), XRCC3 (irs1SF) and XRCC2 (irs1)] were exposed to gamma rays (137Cs), protons (200 MeV; 2.2 keV/μm) and C ions (290 MeV; 50 keV/μm). V3 and XR1 cells lack the NHEJ pathway, whereas irs1 and irs1SF cells lack the HR pathway. After each exposure, survival was measured using a clonogenic survival assay, in situ DSB induction was evaluated by immunocytochemical analysis of histone H2AX phosphorylation at serine 139 (γ-H2AX foci) and chromosome aberrations were examined using solid staining. The findings from this study showed that clonogenic survival clearly depended on the NHEJ and HR pathway statuses, and that the DNA-PKcs−/− cells (V3) were the most sensitive to all radiation types. While protons and γ rays yielded almost the same biological effects, C-ion exposure greatly enhanced the sensitivity of wild-type and HR-deficient cells. However, no significant enhancement of sensitivity in cell killing was seen after C-ion irradiation of NHEJ deficient cells. Decreases in the number of γ-H2AX foci after irradiation occurred more slowly in the NHEJ deficient cells. In particular, V3 cells had the highest number of residual γ-H2AX foci at 24 h after C-ion irradiation. Chromosomal aberrations were significantly higher in both the NHEJ- and HR-deficient cell lines than in wild-type cell lines in response to all radiation types. Protons and gamma rays induced the same aberration levels in each cell line, whereas C ions introduced higher but not significantly different aberration levels. Our results suggest that the NHEJ pathway plays an important role in repairing DSBs induced by both clinical proton and C-ion beams. Furthermore, in C ions the HR pathway appears to be involved in the repair of DSBs to a greater extent compared to gamma rays and protons.

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Carbon beam dosimetry intercomparison at HIMAC

Cited by 24 publications

References 8 publications

Single track coincidence measurements of fluorescent and plastic nuclear track detectors in therapeutic carbon beams

Single track coincidence measurements of fluorescent and plastic nuclear track detectors in therapeutic carbon beams

Comparison of Biological Effectiveness of Carbon-Ion Beams in Japan and Germany

The Major DNA Repair Pathway after Both Proton and Carbon-Ion Radiation is NHEJ, but the HR Pathway is More Relevant in Carbon Ions

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