Carbon-13 Nuclear Magnetic Resonance Study of Naproxen Interaction with Cyciodextrins in Solution

Comparative Effects of (SBE)7m‐β‐CD and HP‐β‐CD on the Stability of Two Anti‐neoplastic Agents, Melphalan and Carmustine

“…[29][30][31][32] However, individual protons will shift to varying extents, depending on the nature of the environment they are in and the proximity of anisotropy-producing functional groups. The nonspecific solvent effect of (SBE) 7m -␤-CD or HP-␤-CD on the chemical shifts of various protons is not likely to be a significant factor at the cyclodextrin concentrations used here.…”

Reversible Pore Block of Connexin Channels by Cyclodextrins

“…To characterize further the nature of CD interaction with connexin, permeability studies were carried out in the presence of CDs and some of their known water-soluble and hydrophobic guest molecules (19,71,72). For these studies, the CDs were applied at concentrations that had no effect on Cx32 channels when applied alone (2 mM ␣CD and 5 mM ␤CD) at 4°C.…”

“…By themselves these guest compounds had no effect on channel activity (naproxen could not be tested due to insolubility). The water-soluble guests 2AA and cinnamic acid were added to the TSF solutions, and the water-insoluble guest naproxen was dehydrated into the CD annulus prior to TSF by repeated lyophilization (71).…”

Interaction of naproxen with ionic cyclodextrins in aqueous solution and in the solid state

“…Naproxen ((S)-(+)-6-methoxy-␣-methyl-2-naphthaleneacetic acid) is a non-steroidal antiinflammatory drug whose very low water solubility (about 27 mg L −1 at 25 • C) can be significantly improved by complexation with native ß-cyclodextrin [1] and even more so with alkyl-and hydroxyalkyl-ß-cyclodextrin-derivatives [2][3][4][5][6]. The several studies performed in this regard have made it possible to highlight the important role of the nature of the cyclodextrin derivatives substituent in determining their solubilizing and complexing power towards naproxen and indicated the methyl-ß-derivative as the most efficient partner for this drug [2][3][4][5][6][7][8].…”