Carbomer gel bearing methotrexate loaded lipid nanocontainers shows improved topical delivery intended for effective management of psoriasis

Tripathi, Priyanka; Kumar, Abdhesh; Jain, Pavan Kumar; Patel, Jay

doi:10.1016/j.ijbiomac.2018.08.136

Cited by 49 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained results indicated that the developed hydrogel carriers significantly reduced irritation in comparison to a conventional MTX loaded hydrogel. Due to the numerous problems associated with the penetration of various types of drugs through the skin, the use of solid lipid nanoparticles (SLNs) and NLCs as carriers of drugs, which show great similarity to skin lipids and quite high stability and the possibility of incorporating drugs of different molecular weight, may increase their deposition in the skin, which may result in prolonged release of therapeutic compounds in its layers [112]. Poorskin permeability of many medicinal substances used in psoriasis therapy significantly reduces their effectiveness at the target site of action.…”

Section: Psoriasismentioning

confidence: 99%

Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review

Zagórska‐Dziok

Sobczak

2020

Pharmaceutics

View full text Add to dashboard Cite

Hydrogels are playing an increasingly important role in medicine and pharmacy. Due to their favorable physicochemical properties, biocompatibility, and designed interaction with living surroundings, they seem to be one of the most promising groups of biomaterials. Hydrogel formulations from natural, semi, or synthetic polymeric materials have gained great attention in recent years for treating various dermatology maladies and for cosmetology procedures. The purpose of this review is to present a brief review on the basic concept of hydrogels, synthesis methods, relevant mechanisms, and applications in dermatology or cosmetology. This review discusses transdermal therapies and the recent advances that have occurred in the field.

show abstract

Section: Psoriasismentioning

confidence: 99%

Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review

Zagórska‐Dziok

Sobczak

2020

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…The most investigated entrapment of drugs and other therapeutics are polymeric hydrogels based on covalent linkages. Numerous such hydrogels containing drug complexes have successfully been developed for skin diseases [ 69 , 70 ], wound healing [ 71 , 72 ], and inflammatory alleviation [ 73 ], among many others.…”

Section: Supramolecular Hydrogels As Carriers For Biologically Active Substancesmentioning

confidence: 99%

From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances

Skopińska-Wiśniewska

Flor

Kozłowska

2021

IJMS

View full text Add to dashboard Cite

Supramolecular hydrogels are 3D, elastic, water-swelled materials that are held together by reversible, non-covalent interactions, such as hydrogen bonds, hydrophobic, ionic, host–guest interactions, and metal–ligand coordination. These interactions determine the hydrogels’ unique properties: mechanical strength; stretchability; injectability; ability to self-heal; shear-thinning; and sensitivity to stimuli, e.g., pH, temperature, the presence of ions, and other chemical substances. For this reason, supramolecular hydrogels have attracted considerable attention as carriers for active substance delivery systems. In this paper, we focused on the various types of non-covalent interactions. The hydrogen bonds, hydrophobic, ionic, coordination, and host–guest interactions between hydrogel components have been described. We also provided an overview of the recent studies on supramolecular hydrogel applications, such as cancer therapy, anti-inflammatory gels, antimicrobial activity, controlled gene drug delivery, and tissue engineering.

show abstract

“…On the other hand, hydrogel presence increases the viscosity of the system, and this influences the applicability and sensory properties as well as prolongs contact time with the skin. Moreover, the nanocarrier/hydrogel matrix systems have increased controlled release, which prolongs the exposition of the skin to the active agent [ 129 , 130 ]. It is also worth noting that when hydrogels are used as the carriers of lipid nanostructures, it is possible to obtain a preparation for topical application with a methotrexate (MTX) immunosuppressant [ 129 ], which is used in the systemic treatment of psoriasis.…”

Section: Polymeric Gels and Their Propertiesmentioning

confidence: 99%

“…Moreover, the nanocarrier/hydrogel matrix systems have increased controlled release, which prolongs the exposition of the skin to the active agent [ 129 , 130 ]. It is also worth noting that when hydrogels are used as the carriers of lipid nanostructures, it is possible to obtain a preparation for topical application with a methotrexate (MTX) immunosuppressant [ 129 ], which is used in the systemic treatment of psoriasis. Tripathi et al showed that this both limited systemic side effects of the application of this drug and had a limited irritating effect in comparison with a typical hydrogel with MTX.…”

Section: Polymeric Gels and Their Propertiesmentioning

confidence: 99%

“…Similarly to hydrogels, emulgels can be a carrier of plant extracts with a potential therapeutic effect [ 172 ] or, similar to oleogels, they can contain fish oil, which can additionally act as a penetration enhancer and have an anti-inflammatory effect [ 175 ]. If microemulsion is used [ 129 ], they can also enable the combination of corticosteroids and substances with keratolytic properties.…”

Section: Polymeric Gels and Their Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Polymeric Gels and Their Application in the Treatment of Psoriasis Vulgaris: A Review

Kulawik‐Pióro

Miastkowska

2021

IJMS

View full text Add to dashboard Cite

Psoriasis is a chronic skin disease, and it is especially characterized by the occurrence of red, itchy, and scaly eruptions on the skin. The quality of life of patients with psoriasis is decreased because this disease remains incurable, despite the rapid progress of therapeutic methods and the introduction of many innovative antipsoriatic drugs. Moreover, many patients with psoriasis are dissatisfied with their current treatment methods and the form with which the drug is applied. The patients complain about skin irritation, clothing stains, unpleasant smell, or excessive viscosity of the preparation. The causes of these issues should be linked with little effectiveness of the therapy caused by low permeation of the drug into the skin, as well as patients’ disobeying doctors’ recommendations, e.g., concerning regular application of the preparation. Both of these factors are closely related to the physicochemical form of the preparation and its rheological and mechanical properties. To improve the quality of patients’ lives, it is important to gain knowledge about the specific form of the drug and its effect on the safety and efficacy of a therapy as well as the patients’ comfort during application. Therefore, we present a literature review and a detailed analysis of the composition, rheological properties, and mechanical properties of polymeric gels as an alternative to viscous and greasy ointments. We discuss the following polymeric gels: hydrogels, oleogels, emulgels, and bigels. In our opinion, they have many characteristics (i.e., safety, effectiveness, desired durability, acceptance by patients), which can contribute to the development of an effective and, at the same time comfortable, method of local treatment of psoriasis for patients.

show abstract

Carbomer gel bearing methotrexate loaded lipid nanocontainers shows improved topical delivery intended for effective management of psoriasis

Cited by 49 publications

References 30 publications

Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review

Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review

From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances

Polymeric Gels and Their Application in the Treatment of Psoriasis Vulgaris: A Review

Contact Info

Product

Resources

About