Carbohydrate Metabolism in Normal Pregnancy

Hurwitz, David; Jensen, Dorothy

doi:10.1056/nejm194603072341004

Cited by 48 publications

(10 citation statements)

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“…These results are not dissimilar to those in Europids where Lind et al (2) found that mean FBG did not change during pregnancy, although values were lower than in nonpregnant women; these findings were similar to those of Hurwitz and Jensen (11). Of more direct relevance to our findings, Famuyiwa et al (7) also reported that in Nigerian women, FBG levels in the three trimesters and postpartum were significantly lower when compared with nonpregnant control subjects.…”

Section: Conclusion-our Results Thussupporting

confidence: 87%

Glucose Tolerance During and After Pregnancy in Nondiabetic Women in an Urban Population in Tanzania

Lutale

Justesen²,

Swai³

et al. 1993

Diabetes Care

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Section: Conclusion-our Results Thussupporting

confidence: 87%

Glucose Tolerance During and After Pregnancy in Nondiabetic Women in an Urban Population in Tanzania

Lutale

Justesen²,

Swai³

et al. 1993

Diabetes Care

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“…The rate of fall, k, obtained from a visual fit of the experimental sugar levels between 10 and 60 minutes to the equation logey = loge A -kt, served as the index of tolerance. A total of 116 healthy women was tested, including 30 nonpregnant, 25 postpartum, and 61 subjects with uncomplicated pregnancies. There was a significant elevation in k during pregnancy.…”

Section: Sum Marymentioning

confidence: 99%

“…The limitations of the oral glucose tolerance test, particularly during pregnancy (20)(21)(22)(23), cast doubt on interpretations indicating impaired tolerance in nondiabetic women (24)(25)(26)(27). Intravenous tolerance tests have been inconclusive (28) with some values (29) were fitted to the equation, log.y = log.A -kt, where y is the blood glucose concentration in milligrams per 100 ml, A is the intercept with the vertical axis, and t is the lapsed time in minutes.…”

mentioning

confidence: 99%

The Rapid Intravenous Glucose Tolerance Test in Pregnancy*

Silverstone¹,

Solomons²,

Rubricius³

1961

J. Clin. Invest.

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“…By this procedure the pregnant women may exhibit a normal tolerance to glucose or may in many instances exhibit a decreased tolerance to glucose (1)(2)(3)(4). Selman (3), for instance, reports 22 out of 47 patients studied by him to show high, prolonged or high and prolonged blood glucose levels when judged by certain criteria.…”

mentioning

confidence: 99%

The Intravenous Glucose Tolerance Test in Pregnancy 1

Johnson¹,

Bonsnes²,

Barad³

1948

J. Clin. Invest.

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Since the introduction of the glucose tolerance test as a diagnostic aid the glucose has-classically been administered by mouth. By this procedure the pregnant women may exhibit a normal tolerance to glucose or may in many instances exhibit a decreased tolerance to glucose (1-4). Selman (3), for instance, reports 22 out of 47 patients studied by him to show high, prolonged or high and prolonged blood glucose levels when judged by certain criteria. Hurwitz and Jensen (4) find normal fasting blood sugar levels and normal peaks, but 81 per cent of their pregnant series showed high blood sugar values at two hours. From these data these authors conclude that pregnancy exerts a deleterious effect on carbohydrate metabolism.The disadvantages of the oral route of administration of the glucose are many and they have been pointed out by several authors (5-9). These disadvantages have led to the use of the intravenous route of administration (8, 9) as a better test of the ability of the subject to metabolize glucose. In pregnancy all the objections to the oral route of administration apply as they do in the nonpregnant individual. In addition, alterations in the gastrointestinal tract peculiar to pregnancy might complicate the picture further.In view of these considerations we have determined the tolerance of pregnant women to intravenously administered glucose. The over-all procedure employed is essentially the same as the one described by Lozner, Winkler, Taylor and Peters (9) who have determined the tolerance of nonpregnant individuals to 25 grams of intravenously administered glucose. SUBJECTS AND METHODSSubjects were chosen from the obstetrical in-patient and out-patient services of the New York Hospital. Only 1 This study was aided by a grant from the John and Mary R. Markle Foundation, women whose course and past history were considered normal were chosen. Individuals with histories of previous glycosuria, or current diabetes, hypertension, kidney or liver disease were eliminated. The tests were performed on subjects at various stages of pregnancy. Subjects for control study were chosen from gynecological in-patients. They were all within the child-bearing age.Only those with benign conditions were selected.There were 20 in the pregnant group. Their ages ranged from 17 to 43 years with an average age of 28.9 years. There were five in the fourth, three in the fifth, two in the sixth, three in the seventh, three in the eighth, one in the ninth, and three in the tenth lunar month of pregnancy. There were 11 in the non-pregnant group. Their ages ranged from 20 to 38 years with an average age of 28.9 years.All subjects were in the post-absorptive state. Some were encouraged to drink 600 to 800 ml. of water before the test was started in order to promote urine flow. A No. 18 Foley indwelling catheter with a 5-ml. bag was placed in the bladder and the bladder emptied. A blood sample was withdrawn. Then 50 ml. of 50 per cent glucose were injected intravenously through a No. 18 needle in 45 to 60 seconds. Blood samples were ...

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Carbohydrate Metabolism in Normal Pregnancy

Cited by 48 publications

References 0 publications

Glucose Tolerance During and After Pregnancy in Nondiabetic Women in an Urban Population in Tanzania

Glucose Tolerance During and After Pregnancy in Nondiabetic Women in an Urban Population in Tanzania

The Rapid Intravenous Glucose Tolerance Test in Pregnancy*

The Intravenous Glucose Tolerance Test in Pregnancy 1

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