Carbohydrate metabolism and endocrine function in the pancreas remnant after major pancreatic resection

Mizumoto, Ryuji; Kawarada, Yoshifumi; Goshima, Hiromichi; Tamaki, Hisao; Sekoguchi, Tsutomu; Tomikawa, Ichiro

doi:10.1016/0002-9610(82)90077-0

Cited by 22 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While it may be speculated that removal of acinar cells belonging to the exocrine portion of the pancreas could account for reductions in body/tissue mass accumulation, it has been reported previously that following 90% pancreatectomy the digestive function of the pancreas is well maintained [66]–[68]. Moreover, the reduction in body mass observed in our Px animals is consistent with the ∼20% reduction in mass observed in hyperglycemic Ins2 Akita +/− mice [14].…”

Section: Discussionsupporting

confidence: 90%

Impaired Growth and Force Production in Skeletal Muscles of Young Partially Pancreatectomized Rats: A Model of Adolescent Type 1 Diabetic Myopathy?

et al. 2010

View full text Add to dashboard Cite

This present study investigated the temporal effects of type 1 diabetes mellitus (T1DM) on adolescent skeletal muscle growth, morphology and contractile properties using a 90% partial pancreatecomy (Px) model of the disease. Four week-old male Sprague-Dawley rats were randomly assigned to Px (n = 25) or Sham (n = 24) surgery groups and euthanized at 4 or 8 weeks following an in situ assessment of muscle force production. Compared to Shams, Px were hyperglycemic (>15 mM) and displayed attenuated body mass gains by days 2 and 4, respectively (both P<0.05). Absolute maximal force production of the gastrocnemius plantaris soleus complex (GPS) was 30% and 50% lower in Px vs. Shams at 4 and 8 weeks, respectively (P<0.01). GP mass was 35% lower in Px vs Shams at 4 weeks (1.24±0.06 g vs. 1.93±0.03 g, P<0.05) and 45% lower at 8 weeks (1.57±0.12 vs. 2.80±0.06, P<0.05). GP fiber area was 15–20% lower in Px vs. Shams at 4 weeks in all fiber types. At 8 weeks, GP type I and II fiber areas were ∼25% and 40% less, respectively, in Px vs. Shams (group by fiber type interactions, P<0.05). Phosphorylation states of 4E-BP1 and S6K1 following leucine gavage increased 2.0- and 3.5-fold, respectively, in Shams but not in Px. Px rats also had impaired rates of muscle protein synthesis in the basal state and in response to gavage. Taken together, these data indicate that exposure of growing skeletal muscle to uncontrolled T1DM significantly impairs muscle growth and function largely as a result of impaired protein synthesis in type II fibers.

show abstract

Section: Discussionsupporting

confidence: 90%

Impaired Growth and Force Production in Skeletal Muscles of Young Partially Pancreatectomized Rats: A Model of Adolescent Type 1 Diabetic Myopathy?

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The pancreatic resection line directly affects pancreatic function, because it reflects the amount of resected pancreatic parenchyma. In our institution, an animal experiment using dogs revealed that diabetes mellitus due to pancreatectomy occurred frequently, especially when more than 70% pancreatectomy was performed in normal pancreas [20]. Additionally, we revealed that NAFLD occurred at a high rate: 87.5% of patients in whom the results of both the PFD test and immunoreactive insulin (IRI) level were less than 50% and 100 μU/ml in previous investigations [19].…”

Section: Discussionmentioning

confidence: 66%

Development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) after pancreaticoduodenectomy: proposal of a postoperative NAFLD scoring system

Kato

Isaji

Azumi

et al. 2009

J Hepato Biliary Pancreat

100

176

View full text Add to dashboard Cite

show abstract

“…In these reports, inadequate pancreatic exocrine function was suggested to be the main cause of de novo NAFLD after pancreaticoduodenectomy 13,15. However, others have suggested that the development of NAFLD after pancreaticoduodenectomy is caused by markedly impaired intestinal absorption, a gut barrier dysfunction with zinc deficiency,15,21,22 and a reduced serum apoB concentration, the latter of which impairs very-low-density lipoprotein secretion and leads to steatogenesis 15. Although, we did not check serum zinc levels and our case did not show steatorrhea or uncontrolled diabetes, we did administer multi-vitamins and the trace elements such as zinc and selenium to counterbalance any trace element deficiency and to maintain pancreatic enzyme levels from just after pancreaticoduodenectomy.…”

Section: Discussionmentioning

confidence: 99%

Severe steatohepatitis with hepatic decompensation resulting from malnutrition after pancreaticoduodenectomy

et al. 2012

View full text Add to dashboard Cite

The most common finding related to nonalcoholic steatohepatitis is obesity, but a status of severe malnutrition can also induce the steatohepatitis. The authors report a rare case of steatohepatitis leading to hepatic decompensation caused by malnutrition after pancreaticoduodenectomy. A 68-year-old female patient who had been previously diagnosed with pancreatic cancer and had undergone pancreaticoduodenectomy 5 months previously presented with abdominal distension. Routine CT performed 3 months after the surgery revealed severe fatty liver without evidence of tumor recurrence. After undergoing pancreaticoduodenectomy her food intake had reduced, and as a result she had lost 7 kg of body weight over 2 months. At this admission, CT revealed moderate amounts of ascites without tumor recurrence. Furthermore, her albumin and lipid profile levels were markedly decreased, and she had a flapping tremor and slurred speech suggestive of hepatic encephalopathy. Her liver biopsy findings were consistent with steatohepatitis and disclosed macrovesicular steatosis without definite fibrosis. After careful nutritional control, her symptoms disappeared and her laboratory findings improved.

show abstract

Carbohydrate metabolism and endocrine function in the pancreas remnant after major pancreatic resection

Cited by 22 publications

References 10 publications

Impaired Growth and Force Production in Skeletal Muscles of Young Partially Pancreatectomized Rats: A Model of Adolescent Type 1 Diabetic Myopathy?

Impaired Growth and Force Production in Skeletal Muscles of Young Partially Pancreatectomized Rats: A Model of Adolescent Type 1 Diabetic Myopathy?

Development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) after pancreaticoduodenectomy: proposal of a postoperative NAFLD scoring system

Severe steatohepatitis with hepatic decompensation resulting from malnutrition after pancreaticoduodenectomy

Contact Info

Product

Resources

About