Carbohydrate loading in the preoperative setting

Hill, Lee; Miller, Malcolm

doi:10.7196/samj.8746

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…This result also matched to the theoretical concept that administration of oral glucose solution preoperatively can trigger the insulin secretion, thus change the patient's metabolic status from fasted state to fed state [8]. The main stress response as a result of surgical trauma is the release of stress hormone and cytokine that comparable with the level of the trauma.…”

Section: Discussionsupporting

confidence: 73%

Metabolic Stress Response Attenuate by Oral Glucose Preoperatively in Patient Underwent Major Surgery with General Anesthesia

Widnyana¹,

Senapathi²,

Aryabiantara³

et al. 2017

Int J Anesth Pain Med

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Background: Fasting, anesthesia and surgery lead to metabolic stress response. Increase of cortisol level lead to insulin resistance and hyperglicemic state has significant effect to the wound healing and increase morbidity and mortality to the patient undergoing surgery. The aim of this research is to prove that preoperative oral glucose loading can decrease metabolic stress response and also the difference effect on preoperative oral glucose that given twice and once time to decrease metabolic stress response in patient undergoing major oncology surgery.

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Section: Discussionsupporting

confidence: 73%

Metabolic Stress Response Attenuate by Oral Glucose Preoperatively in Patient Underwent Major Surgery with General Anesthesia

Widnyana¹,

Senapathi²,

Aryabiantara³

et al. 2017

Int J Anesth Pain Med

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The effects of preoperative carbohydrate loading on the metabolic response to surgery in a low resource setting

Weledji

Njong

Chichom

et al. 2017

International Journal of Surgery Open

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Background The stress response to surgery involves catabolism and gluconeogenesis resulting in postoperative hyperglycaemia. Postoperative hyperglycaemia is a risk factor for postoperative complications and preoperative fasting further aggravates this response. A carbohydrate (CHO) drink instead of fasting is expected to decrease insulin resistance and reduce post-operative hyperglycaemia. The aim of this study was to assess the effect of the reduction of the pre-operative fasting period on post-operative hyperglycaemia and post-operative complications in open surgery. Methods A hospital-based prospective case control study of 70 patients scheduled for elective surgery were sampled to either a case (carbohydrate-loaded) or a control (FAST) group. Postoperative hyperglycaemia and complications were the primary and secondary outcomes respectively reported. Results 70 patients were recruited with 35 patients per group. 40 (57%) were females. The mean blood glucose on the first postoperative day was significantly higher in those who fasted (146.20 ± 38.36 mg/dl) than in those who received the energy drink (123.06 ± 26.64 mg/dl), p = 0.004. Postoperative infections were significantly higher in the control group than in the CHO group (31.43%; and 8.57%; 95% C.I: 1.23–19.47) p = 0.033. The mean length of hospital stay was longer in the FAST (12.54days ± 15.08) than in the CHO (9.17days ± 12.65) group although the difference was not statistically significant p = 0.315. The mean age, surgery type and mean duration of surgery were significant between groups but not upon logistic regression for significant clinical and demographic variables. Conclusion Preoperative CHO loading is effective and safe in reducing post-operative hyperglycaemia and infection in open general surgery even in a low resource setting. Highlights

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Carbohydrate loading in the preoperative setting

Cited by 2 publications

References 12 publications

Metabolic Stress Response Attenuate by Oral Glucose Preoperatively in Patient Underwent Major Surgery with General Anesthesia

Metabolic Stress Response Attenuate by Oral Glucose Preoperatively in Patient Underwent Major Surgery with General Anesthesia

The effects of preoperative carbohydrate loading on the metabolic response to surgery in a low resource setting

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