Abstract:The high transmissibility and genetic variability of the influenza virus have made the design of effective approaches to control the infection particularly challenging. The virus surface hemagglutinin (HA) protein is responsible for the viral attachment to the host cell surface via the binding with its glycoligands, such as sialyllactose (SL), and thereby is an attractive target for antiviral designs. Herein we present the facile construction and development of two SL-incorporated chitosan-based materials, eit… Show more
“…Many chitosan derivatives, such as trimethyl chitosan, Zwitterionic chitosan, and glycated chitosan, have been invented recently [62–65]. With the development of nanotechnology, chitosan have shown its unique advantages when combined with nanoparticles.…”
With the development of cancer immunotherapy, cancer vaccine has become a novel modality for cancer treatment, and the important role of adjuvant has been realized recently. Chitin, chitosan, and their derivatives have shown their advantages as adjuvants for cancer vaccine. In this paper, the adjuvant properties of chitin and chitosan were discussed, and some detailed information about glycated chitosan and chitosan nanoparticles was also presented to illustrate the trend for future development.
“…Many chitosan derivatives, such as trimethyl chitosan, Zwitterionic chitosan, and glycated chitosan, have been invented recently [62–65]. With the development of nanotechnology, chitosan have shown its unique advantages when combined with nanoparticles.…”
With the development of cancer immunotherapy, cancer vaccine has become a novel modality for cancer treatment, and the important role of adjuvant has been realized recently. Chitin, chitosan, and their derivatives have shown their advantages as adjuvants for cancer vaccine. In this paper, the adjuvant properties of chitin and chitosan were discussed, and some detailed information about glycated chitosan and chitosan nanoparticles was also presented to illustrate the trend for future development.
“…Influence virus start the infection of host cells by its surface hemagglutinin (HA) protein that binds to its glycoligands, such as sialyllactose (SL). The group of Cheng and co-workers 167 presented the construction of two SL-incorporated chitosan-based materials, either as a water-soluble polymer or as a functional fiber, and demonstrated their abilities for viral adhesion inhibition and decontamination.…”
“…Polymeric membranes formed from chitosan and polyvinyl alcohol nanofibres cross-linked with glutaraldehyde have the ability to adsorb porcine parvovirus (PPV) and sindbis virus (SINV) particles [23,24]. Influenza A virus particles may be adsorbed by the carbohydrate-functionalized chitosan filaments [25]. The application of proteins and peptides as adsorbents has been also reported [26,27].…”
A novel biopolymeric material in the form of nano/microspheres was developed which was capable of adsorbing coronaviruses. The biopolymer was obtained by crosslinking of chitosan (CHIT) with genipin, a nontoxic compound of plant origin, in inverted emulsion and reacting the chitosan nano/microspheres obtained (CHIT-NS/MS) with glycidyltrimethyl-ammonium chloride (GTMAC). As a result the nano/microspheres of N-(2-hydroxypropyl)-3-trimethyl chitosan (HTCC-NS/MS) were obtained. HTCC-NS/MS were studied as the adsorbents of human coronavirus NL63 (HCoV-NL63), mouse hepatitis virus (MHV), and human coronavirus HCoV-OC43 particles in aqueous virus suspensions. By studying cytopathic effect (CPE) caused by these viruses and performing PCR analyses it was found HTCC-NS/MS strongly adsorb the particles of HCoV-NL63 virus, moderately adsorb mouse hepatitis virus (MHV) particles, but do not adsorb HCoV-OC43 coronavirus. The adsorption capacity of HTCC-NS/MS well correlated with the antiviral activity of soluble HTCC against a given virus. Importantly, it was shown that HCoV-NL63 particles could be desorbed from the HTCC-NS/MS surface with a salt solution of high ionic strength with retention of virus virulence. The obtained material may be applied for the removal of coronaviruses, purification and concentration of virus samples obtained from biological matrices and for purification of water from pathogenic coronaviruses.
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