Carbohydrate-Deficient Transferrin: Validity of a New Alcohol Biomarker in a Sample of Patients with Diabetes and Hypertension

Fleming, Michael F.; Mundt, Marlon

doi:10.3122/jabfm.17.4.247

Cited by 42 publications

(31 citation statements)

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“…This observation supports the data of Figlie et al [15]. The higher values measured in women under the age of 45 years can be explained by hormonal contraception, regular use of cosmetics and hormone-containing hair-dyes [16,17]. Based on data of the literature, CDT clearly seems to be a better parameter for assessing alcohol consumption than GGT or MCV [3,5,11].…”

Section: Discussionsupporting

confidence: 84%

Levels of carbohydrate-deficient transferrin according to gender and age in a small town in Hungary

Szabó¹,

Környei²,

Keller³

et al. 2009

Clinical and Experimental Medical Journal

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Abbreviations ALT = alanine aminotransferase; AST = aspartate aminotransferase; CDT = carbohydrate-deficient transferrin; GGT = gamma-glutamyl transpeptidase; HPLC = high performance liquid chromatography; MCV = mean corpuscular volume The estimated amounts of alcohol consumed regularly are data recorded on the basis of patients' self-report at history-taking. In many instances, however, patients do not genuinely inform their physician on the extent of their alcohol consumption, and in some cases they simply conceal it. In such cases determination of the amount of carbohydrate-deficient transferrin (CDT) can be helpful. Objective: To determine the levels of carbohydrate-deficient transferrin in a healthy population. Methods: The authors performed examinations among inhabitants of a small Hungarian town (Enese). Data of 409 individuals (average age: 49.7 years) have been processed. They included 204 men (average age: 49.3 years) and 205 women (average age: 50.3 years). Subjects were divided into two groups: 1) those who consumed no alcohol or only small quantities (< 40 g/day) and 2) the so-called social drinkers who consumed an amount corresponding to 40 to 60 g alcohol/day. Levels of carbohydrate-deficient transferrin were measured by immune turbidimetry with an automated instrument Hitachi 912 (Roche USA).Results: In persons consuming no or only small quantities of alcohol, the levels of CDT rise gradually with the increasing age. In the age group between 45 and 65 years the values are significantly higher than in people under 25 years of age. In the younger age group under 45 years, women were found to have significantly higher levels than men. In the social drinkers (beverage consumption corresponding to 40 to 60 g alcohol/day) the values were higher in all cases as compared to those in the non-consuming group, and in the age group between 45 and 65 years the levels were significantly higher than in the younger age group. Of them, men had significantly higher values as compared to women. Conclusion: CDT levels show a moderate rise with the age, and social drinking increases the values as well.

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Section: Discussionsupporting

confidence: 84%

Levels of carbohydrate-deficient transferrin according to gender and age in a small town in Hungary

Szabó¹,

Környei²,

Keller³

et al. 2009

Clinical and Experimental Medical Journal

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“…New biomarkers that have high specificity and sensitivity are increasingly being used today. One of them is CDT, the first test to be approved in the USA by the FDA (Food and Drug Administration) as the biomarker for alcoholism (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Carbohydrate-Deficient Transferrin - A Contemporary Biomarker in Comparison with Traditional Laboratory Markers of Chronic Alcohol Abuse

Maksić¹,

Vodnik²,

Stanković³

et al. 2010

Journal of Medical Biochemistry

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Summary: Timely identification of excessive alcohol use and its potential complications is a prerequisite for successful treatment. Several routine tests have been used in laboratories that may help in diagnosing alcoholism, such as determination of MCV, AST, ALT, GGT, but it has been shown that they lack specificity and sensitivity. Contemporary biomarkers are increasingly being used today that may due to their unique characteristics help in disco vering the onset of chronic alcohol abuse, as well as in abstinence and relapse monitoring. The term carbohydrate-deficient transferrin (CDT) stands for a small group of human transferrin isoforms (asialo, monosialo, and disialotran sferrin) with a lower degree of glycosylation in comparison to the dominant transferrin isoform (tetrasialotransferrin). Persons consuming large quantities of alcohol (≥50 -80 g daily) over a period of at least two weeks have increased concentrations of transferrin isoforms lacking one (disialo transferrin) or both (asialotransferrin) carbohydrate chains. In this paper the traditional markers of chronic alcohol abuse (GGT, AST, ALT, and MCV) were determined, as well as the new biomarker CDT, after which diagnostic evaluation was performed and their usability and clinical value in routine laboratory practice were estimated. These markers were also determined in heavy alcoholics on admission into hospital and after two weeks of therapy, with the aim of estimating their diagnostic value for abstinence and relapse monitoring. Keywords: alcoholism, biomarkers, CDT, transferrinKratak sadr`aj: Pravovremeno prepoznavanje preko merne upotrebe alkohola i potencijalnih komplika cija pred uslov je za uspe{no le~enje. U laboratorijama se koristi neko liko rutinskih testova koji mogu da pomognu u dijagnostici alkoholizma, kao npr. odre|ivanje MCV, AST, ALT, GGT, ali su se pokazali kao nedovoljno specifi~ni i osetljivi. Danas su sve vi{e u upotrebi savremeni biomarkeri koji zahvaljuju}i svojim jedin stvenim osobinama mogu da pomognu kod otkrivanja po ja ve hroni~nog alkoholizma, kao i pri pra}enju apstinencije i relapsa. Naziv transferin deficijentan ugljenim hidratima (CDT) podrazumeva manju grupu izoformi humanog trans ferina (asialo-, monosialo-i disialo-transferin), koje imaju ni`i stepen glikozilacije u pore|enju sa do minantnom izo for mom transferina (tetrasialotran sfe rin). Osobe koje unose velike koli~ine alkohola (≥50-80 g dnevno) u periodu od najmanje 2 nedelje imaju povi{ene koncentracije izoformi transferina kojima nedostaje jedan (disialotransferin) ili oba (asialotransferin) ugljeno hidratna lanca. U ovom radu oba vlje no je odre|ivanje tradicionalnih marke ra hroni~ne alko ho lne potro{nje (GGT, AST, ALT i MCV), kao i novog bio markera CDT, a zatim je izvr{ena dijagno sti~ka evaluacija i procena njihove upotrebljivosti i klini~ke vrednosti u rutin skoj laboratorijskoj praksi. Tako|e je izvr{eno odre|ivanje navedenih markera kod te{kih alkoholi~ara pri prijemu na bolni~ko odeljenje i nakon 2 nedelje terapije u cilju proce ne njihove dijag...

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“…CDT test characteristics were determined through a study involving a primary care sample of 799 patients (Fleming and Mundt 2004). Cost estimates for the decision tree were derived from the Trial of Early Alcohol Treatment (Project TrEAT) (Fleming et al, 2002).…”

Section: Michael F Fleming and Kathyrn Sullivan Dilliementioning

confidence: 99%

Alcohol Biomarker Screening in Medical and Surgical Settings

Miller¹,

Spies

Neumann

et al. 2006

Alcoholism Clin & Exp Res

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This article highlights the proceedings of a symposium presented at the 28th Annual Meeting of the Research Society on Alcoholism in Santa Barbara, CA, on June 28, 2005, organized and chaired by Peter Miller. The presentations included (1) Screening for Alcohol Use Disorders in Surgical and Trauma Patients, presented by Claudia Spies; (2) Are Serum Levels of %CDT and GGT Related to Severity of Liver Biopsy Inflammation, Fibrosis, and Steatohepatitis in Patients with Hepatitis C? by Martin Javors; (3) Biochemical Alcohol Screening in the Treatment of Hypertension, presented by Peter Miller; and (4) The Cost-Effectiveness of a New Biomarker, CDT, in a Primary Care Sample, by Michael Fleming. Presentations were discussed by Raymond Anton.

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Carbohydrate-Deficient Transferrin: Validity of a New Alcohol Biomarker in a Sample of Patients with Diabetes and Hypertension

Cited by 42 publications

References 40 publications

Levels of carbohydrate-deficient transferrin according to gender and age in a small town in Hungary

Levels of carbohydrate-deficient transferrin according to gender and age in a small town in Hungary

Carbohydrate-Deficient Transferrin - A Contemporary Biomarker in Comparison with Traditional Laboratory Markers of Chronic Alcohol Abuse

Alcohol Biomarker Screening in Medical and Surgical Settings

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