Carbohydrate-binding proteins of marine invertebrates

Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (−)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (−)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1–5 (TH 1–5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the afore-mentioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.

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“…The inhibitory activity of some of these lectins against human immunodeficiency virus has been examined (Luk’ianov et al 2007). …”

Section: Antiviral Activity Of Invertebrate Productsmentioning

confidence: 99%

Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

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“…A scarce number of reports deal with molluscan natural products’ effectivity against their peculiar viral infections, but, on the other hand, a large number of human viral pathogens have been found susceptible to molluscan metabolites reflecting a lack of tailored antiviral response in their innate immune system (Dang et al., ). Secondary metabolites isolated from no less than eight gastropods ( Haliotis laevigata , Haliotis rubra , Haliotis rufescens , Littorina littorea , Buccinulum corneum , Tegula gallina , Rapana venosa , and Buccinum undatum ) (Table ), and nine bivalves ( Mercenaria mercenaria , Mya arenaria , R. philippinarum , Cerastoderma edule , Mytilus galloprovincialis , Crenomytilus grayanus , Crassostrea virginica , Crassostrea gigas , and Ostrea edulis ) (Table ) have been described as potent against many, generally human, viruses (Dang, Benkendorff, & Speck, ; Dang, Speck, Doroudi, Smith, & Benkendorff, ; Defer, Bourgougnon, & Fleury, , ; Dolashka et al., ; Dolashka‐Angelova et al., ; Dupuy, Bonami, & Roch, ; Genova‐Kalou et al., ; Li, ; Li & Traxler, ; Li et al., ; Li, Prescott, & Jahnes, ; Luk'yanov et al., ; Marderosian, ; Olicard, Didier, Marty, Bourgougnon, & Renault, ; Olicard, Renault, Torhy, Benmansour, & Bourgougnon, ; Prescott, Li, Caldes, & Martino, ; Roch, Beschin, & Bernard, ; Roch, Yang, Toubiana, & Aumelas, ; Silvestri et al., ). An extraordinarily large number (roughly 100,000 species) of mollusks, hence, remains untested for potential antiviral efficacy (Dang et al., ).…”

Section: Health‐promoting Efficacy Of Marine Mollusksmentioning

confidence: 99%

“…Proteins and glycoproteins are the most abundant compounds found in molluscan extracts active against viruses (Dang et al., ). To quote some examples, kelletinin A ( B. corneum ) has been found active against Human T‐cell leukemia virus type 1 (Orlando, Strazzullo, Carretta, De Falco, & Grippo, ; Silvestri et al., ), hemocyanin ( R. venosa ) against Respiratory syncytial virus, Herpes simplex virus (HSV)‐1 and ‐2, and Epstein–Barr virus (EBV) (Dolashka et al., ; Dolashka‐Angelova et al., ; Genova‐Kalou et al., ; Nesterova et al., ), mytilin ( M. galloprovincialis ) against White spot syndrome virus (Dupuy et al., ), defensin ( M. galloprovincialis ) against human immunodeficiency virus type 1 (HIV‐1) (Roch et al., ), while lectin ( C. grayanus ) against HIV (Luk'yanov et al., ). Though their exact mechanism of action is hitherto unknown, apparently, they counteract invading virus either by directly inactivating it and preventing its binding to or entrance into target cells or by inhibiting its replication and transcription (Dang et al., ).…”

Section: Health‐promoting Efficacy Of Marine Mollusksmentioning

confidence: 99%

Marine Mollusks: Food with Benefits

Khan

Yang

2019

Comp Rev Food Sci Food Safe

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The extremely vast biodiversity represented by marine mollusks alongside their widespread utility as a source of food and their high nutritional value has aroused great interest from the scientific community. Furthermore, they can be caught with ease, and their commercial breeding and farming is rampant. This article comprehends the global availability of these organisms, their pretreatment and handling procedures, and their health‐promoting potential with a focus on their antiviral, anti‐inflammatory, and antimicrobial properties. The emphasis herein is on their potential use in the food and nutraceutical industry. In addition, mollusks consumption as part of everyday diet can also be helpful in avoiding many ailments as they are rich in vital nutrients and active secondary metabolites, as well as have the ability to enhance immune response. Moreover, the available literature suggests that normal cooking practices have no notable adverse effects on their nutritional value and they retain certain bioactivities even after the action of digestive enzymes. Though mollusks have been widely studied in relation to the health‐promoting effects reviewed here, there is still more scope for further research in this direction in order to fully utilize this enormous source of food and nutraceuticals.

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“…It inhibited HIV-1-induced cytopathy and viral p24 antigen production in host cells with EC 50 values of 0.15 and 0.23 μg/ml, respectively. Luk'ianov et al (2007) purified three lectins from Crenomytilus grayanus (designated as CGL) and Didemnum ternatanum (designated as DTL and DTL-A). CGL manifested high specificity to glycoproteins Table 2 Amino acid sequences of selected algal lectins B*^, B+^, and B-^represent identical, similar amino acids within the proteins and gaps in alignments, respectively of the mucin type.…”

Section: Antiviral Activitymentioning

confidence: 99%

Marine lectins and their medicinal applications

Cheung

Wong

Pan

et al. 2015

Appl Microbiol Biotechnol

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Marine organisms have been extensively explored for the last several decades as potential sources of novel biologically active compounds, and extensive research has been conducted on lectins. Lectins derived from marine organisms are structurally diverse and also differ from those identified from terrestrial organisms. Marine lectins appear to be particularly useful in some biological applications. They seem to induce negligible immunogenicity because they have a relatively small size, are more stable due to extensive disulfide bridge formation, and have high specificity for complex glyco-conjugates and carbohydrates instead of simple sugars. It is clear that many of them have not yet been extensively studied when compared with their terrestrial counterparts. Marine lectins can be used to design and develop new potentially useful therapeutic agents. This review encompasses recent research on the isolation and identification of marine lectins with potential value in medicinal applications.

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Carbohydrate-binding proteins of marine invertebrates

Cited by 24 publications

References 30 publications

Antifungal and antiviral products of marine organisms

Antifungal and antiviral products of marine organisms

Marine Mollusks: Food with Benefits

Marine lectins and their medicinal applications

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