Carbohydrate-Based Copolymers. Hydrolysis of Copoly(ester amide)s Containing <scp>l</scp>-Arabinose Units

Pinilla, Inmaculada Molina; Martı́nez, Manuel Bueno; Galbis, Juan A.

doi:10.1021/ma0113024

Cited by 7 publications

(2 citation statements)

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“…Additionally, carbohydrates and their derivatives are of ubiquity and convenient availability. A multitude of studies have been conducted on the synthesis of PEAs by monosaccharide (e.g., l -arabinose, d -xylose), polysaccharide (e.g., starch), polyol (e.g., xylitol, sorbitol, glucitol), and other corresponding carbohydrate derivatives (Figure ).…”

Section: Synthesis Of Poly(ester Amide)smentioning

confidence: 99%

Recent Advances of Poly(ester amide)s-Based Biomaterials

Han

2022

Biomacromolecules

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Biodegradable and biocompatible biomaterials have offered much more opportunities from an engineering standpoint for treating diseases and maintaining health. Poly(ester amide)s (PEAs), as an outstanding family among such biomaterials, have risen overwhelmingly in the past decades. These synthetic polymers have easily and widely available raw materials and a diversity of synthetic approaches, which have attracted considerable attention. More importantly, combining the superiorities of polyamides and polyesters, PEAs have emerged with better functions. They could have improved biodegradability, biocompatibility, and cell− material interactions. The PEAs derived from α-amino acids even allow the introduction of pendant sites for further modification or functionalization. Meanwhile, it is gradually recognized that the chemical structures are closely related to the physiochemical and biological properties of PEAs so that their properties can be precisely controlled. PEAs therefore become significant materials in the biomedical fields. This review will attempt to summarize the recent progress in the development of PEAs with respect to the preparation materials and methods, structure−property relationships along with their latest biomedical accomplishments, especially for drug delivery and tissue engineering.

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Section: Synthesis Of Poly(ester Amide)smentioning

confidence: 99%

Recent Advances of Poly(ester amide)s-Based Biomaterials

Han

2022

Biomacromolecules

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“…Their thermal properties have been studied by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Their in vitro hydrolysis has been evaluated and studied in a different paper …”

Section: Introductionmentioning

confidence: 99%

Carbohydrate-Based Copolymers. Synthesis and Characterization of Copoly(ester amide)s Containing l-Arabinose Units

et al. 2002

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Copoly(ester amide)s, abbreviated as PVGAn, have been prepared by random copolymerization of 1-amino-1-deoxy-2,3,4-tri-O-methyl-5-O-[(pentachlorophenoxy)succinyl]-l-arabinitol hydrochloride and 5-amino-1-O-[(pentachlorophenoxy)glutaryl]pentanol hydrochloride by the active ester polycondensation method. The molar ratios of the two comonomers in the feed varied from 1/99 to 50/50. The two monomeric units are randomly distributed within the copolymers, as assessed by NMR analysis, and the degree of randomness and average sequence lengths of the different copoly(ester amide)s have been experimentally determined. Thermal properties depend on the copoly(ester amide) composition, since it was found that the melting and the decomposition temperatures decreased as the molar fraction of carbohydrate-based monomer unit increased, whereas the glass-transition temperature increased in parallel.

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Random multiblock poly(ester amide)s containing poly(L‐lactide) and cycloaliphatic amide segments: Synthesis and biodegradation studies

Luckachan

Pillai

2006

J. Polym. Sci. A Polym. Chem.

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Novel multiblock poly(ester amide)s containing poly(L‐lactide) and cycloaliphatic amide segments were synthesized from telechelic oligomer of α,ω‐hydroxyl terminated poly(L‐lactide), 1,3‐cyclohexylbis(methylamine), and sebacoylchloride by the “two‐step” interfacial polycondensation method. The blocky nature of PEAs was established by FTIR and 1H NMR spectroscopies. The effect of relative content of ester and amide segments on the crystallization nature of PEAs was investigated by WAXD and DSC analyses. PEAs having lower content of PLLA, PEA 1 and PEA 2, showed a crystallization pattern analogous to polyamides, whereas PEA 3, having higher content of PLLA, showed two crystalline phases characterized by polyester and polyamide segments. Random nature of PEAs was observed from single Tg values. Biodegradation studies using the enzyme lipase from Candida Cylindracea showed higher degradation rate for PEA 3 than that for PEA 1 and PEA 2. FTIR, 1H NMR, and DSC analyses of the degraded products indicated the involvement of ester linkages in the degradation process. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 3250–3260, 2006

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Carbohydrate-Based Copolymers. Hydrolysis of Copoly(ester amide)s Containing l-Arabinose Units

Cited by 7 publications

References 20 publications

Recent Advances of Poly(ester amide)s-Based Biomaterials

Recent Advances of Poly(ester amide)s-Based Biomaterials

Carbohydrate-Based Copolymers. Synthesis and Characterization of Copoly(ester amide)s Containing l-Arabinose Units

Random multiblock poly(ester amide)s containing poly(L‐lactide) and cycloaliphatic amide segments: Synthesis and biodegradation studies

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