Carbohydrate Assimilation and Utilization by Newborn Pigs

Curtis, S. E.; Heidenreich, C. J.; Foley, C. Michael

doi:10.2527/jas1966.253655x

Cited by 29 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, unlike the piglet, most of the extra heat required to maintain homeo thermy in the human infant is generated through non-shivering thermogenesis [19]. Under thermoneutral conditions the glucose disappearance rate, the basal insulin level and its response to glucose administration observed in the present experiments is simi lar to that previously reported for piglets [12,16,37],…”

Section: Fig 3 the Rate O F Glucose Disappearance (K(l; %/Min) And supporting

confidence: 78%

Influence of Environmental Temperature on Glucose Tolerance and Insulin Response in the New-Born Piglet

Close¹,

Dividich

Duée

1985

Neonatology

View full text Add to dashboard Cite

Plasma glucose and insulin concentrations were measured in 45 new-born piglets both before and at regular intervals throughout a 2-hour period following an intravenous administration of glucose (1 g/kg body weight), at environmental temperatures of 17, 24 and 33 °C. As anticipated, rectal temperature (TR was dependent upon the environmental temperature. During the glucose tolerance test (GTT), TR remained constant at both 24 and 33 °C, 37.0 ± 0.2 compared with 38.0 ± 0.1 °C. However at 17 °C, 12 piglets were able to maintain a constant TR (35.8 ± 0.2 °C), whereas the remaining 6 piglets became hypothermic (32.8 ± 0.4 °C), with TR decreasing continuously throughout the GTT. Their body weight was 210 g below that of the other piglets (p < 0.05). Those piglets at 17 and 24 °C which maintained homeothermy had a higher glucose disappearance rate (KG; 2.00 and 2.31%/min, respectively) than those kept within thermal neutrality (1.66%/min). The insulin response to glucose was similar. During hypothermia, on the other hand, both KG (0.76 ± 0.12%/min) and the insulin response were significantly less (p < 0.05) than in all other piglets. These results indicate that the glucose uptake by the skeletal muscle is increased in cold-exposed, normothermic piglets and results in an increased metabolic rate. Failure to maintain homeothermy diminishes glucose uptake and inhibits insulin release.

show abstract

Section: Fig 3 the Rate O F Glucose Disappearance (K(l; %/Min) And supporting

confidence: 78%

Influence of Environmental Temperature on Glucose Tolerance and Insulin Response in the New-Born Piglet

Close¹,

Dividich

Duée

1985

Neonatology

View full text Add to dashboard Cite

show abstract

“…Brooks and Davis (1969) (Mersmann et al 1972) to 8.2 and 7.2Vo (Shelley 1961), respectively, but a low liver glycogen value of 2.36Vc was reported by Buitrago et al (19'7 4 (Holub 1971) that the normal glycogen reserve of the newborn pig would meet its energy needs for only 7-8 h. Reports of direct, detailed measurement of depletion rate in the neonatal pig over several days are limited. Curtis et al (1966) found reduc-tions in total carbohydrate concentration of liver and muscle (gluteus maximus), respec-tively, from 12.2 to 8.0Vo and from 8.0 to 7. }Vo dwing the first 8 h of life.…”

mentioning

confidence: 99%

Body Composition and Glycogen Reserves in the Neonatal Pig During the First 96 Hours Postpartum

Elliot¹,

Lodge²

1977

Can. J. Anim. Sci.

View full text Add to dashboard Cite

show abstract

“…A systematic study of the tolerance of sows to intravenous injections of glucose has not been reported, although several workers have studied the intravenous glucose tolerance of immature pigs [Hanawalt, Link and Sampson, 1947; Link, 1953;Meyer, Briskey, Hoekstra and Bray, 1962;Curtis, Heidenreich and Folley, 1966]. In addition none of these workers made any attempt to assess the results of an intravenous glucose tolerance test (IVGTT) in a quantitative manner such as was described by Duncan [1956] in his work with man.…”

mentioning

confidence: 99%

The Intravenous Glucose Tolerance Test in the Pig

Anderson¹,

Elsley²

1970

Exp Physiol

View full text Add to dashboard Cite

After intravenous injection of 50 g glucose the blood glucose concentration in sows declined very quickly from the high concentrations initially found. The blood glucose concentration always returned to the fasting concentration within the period 18-45 min after glucose injection. The rate at which the glucose was removed was a function of the total blood glucose concentration.After the blood glucose concentration returned to the fasting concentration, the concentration continued to fall, concentrations of 5-10 mg/100 ml. being achieved regularly with no overt signs of hypoglycaemia.The time required for the blood glucose concentration to return to the fasting glucose concentration was found to be the most repeatable quantitative assessment of the test in the pig.A systematic study of the tolerance of sows to intravenous injections of glucose has not been reported, although several workers have studied the intravenous glucose tolerance of immature pigs [Hanawalt, Link and Sampson, 1947; Link, 1953;Meyer, Briskey, Hoekstra and Bray, 1962;Curtis, Heidenreich and Folley, 1966]. In addition none of these workers made any attempt to assess the results of an intravenous glucose tolerance test (IVGTT) in a quantitative manner such as was described by Duncan [1956] in his work with man. The aim of the work reported in this paper was to develop a method of assessing quantitatively the results of an IVGTT in the sow, and to determine whether there was a sufficient range in the glucose tolerance between sows to merit studies now proceeding of any possible relation between the sow's glucose tolerance and the birth weight of her litters. A relation of this nature had already been demonstrated in the case of man where a state of diabetes or pre-diabetes results in heavier babies at birth [Kyle, 1963]. METHODSThe animals used were Large White sows drawn from the Rowett Research Institute pig herd. The tests were undertaken either when the animals were non-pregnant and had not been lactating for some weeks or in the first 14 days of pregnancy. Animals were given a uniform feed intake of 2-2 kg per day of a standard diet [Elsley, Anderson, McDonald, McPherson and Smart, 1966] and had been receiving this diet for at least three weeks prior to the test. On the day before the test, an indwelling catheter was placed in the jugular vein, and in some cases in the carotid artery, using a method described previously [Anderson and Elsley, 1969].On the morning of the test, three initial samples of blood were withdrawn from the animal by means of the catheter. A standard dose of 50 g of glucose in 50 per cent * Present address: Institute of Animal Physiology, Babraham, Cambridge. 104

show abstract

Carbohydrate Assimilation and Utilization by Newborn Pigs

Cited by 29 publications

References 14 publications

Influence of Environmental Temperature on Glucose Tolerance and Insulin Response in the New-Born Piglet

Influence of Environmental Temperature on Glucose Tolerance and Insulin Response in the New-Born Piglet

Body Composition and Glycogen Reserves in the Neonatal Pig During the First 96 Hours Postpartum

The Intravenous Glucose Tolerance Test in the Pig

Contact Info

Product

Resources

About