Carbohydrate Antigen 19–9 Producing Giant Epithelial Cyst of the Spleen in a Young Woman

Terada, Tadashi; Yasoshima, Mitsue; Yoshimitsu, Yutaka; Nakanuma, Yasuni

doi:10.1097/00004836-199401000-00014

Cited by 28 publications

(11 citation statements)

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“…High concentrations of CA 19-9 have been found in the serum and fluid of cysts in association with the immunoreactivity to CA 19-9 of the epithelium of primary spleen cysts 9. High concentrations of CEA and cancer CA 125 have also been found in the serum and fluid of primary epithelial spleen cysts 10.…”

Section: Discussionmentioning

confidence: 96%

Primary epithelial splenic cyst with micro-rupture and raised carbohydrate antigen CA 19-9: a paradigm of management

Papadopoulos¹,

Davatzikos

Kasabalis

et al. 2010

Case Reports

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SummaryEpithelial splenic cysts are rare entities that surgeons might not have previously encountered and their management is based on historical studies.A 21-year-old female presented with a cyst of the spleen that produced a high serum concentration of carbohydrate antigen CA 19-9. A partial splenectomy with the removal of the entire cyst and preservation of splenic parenchyma by laparotomy was performed and the patient made an uneventful recovery. A microscopic rupture of the wall of the cyst and degradation of blood in the fluid of the cyst were confirmed. Eighteen months following surgery a functional splenic parenchyma was documented. There was no episode of infection during this follow-up time.Partial surgical splenectomy with resection of the entire cyst prevents recurrence and preserves splenic function. BACKGROUND

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Section: Discussionmentioning

confidence: 96%

Primary epithelial splenic cyst with micro-rupture and raised carbohydrate antigen CA 19-9: a paradigm of management

Papadopoulos¹,

Davatzikos

Kasabalis

et al. 2010

Case Reports

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“…However, its usefulness is rather limited because elevated serum values of CA 19-9 may be encountered in patients with other gastrointestinal adenocarcinomas or even benign disorders, with a sensitivity and specificity of 77% and 88%, respectively 3. The first case of a splenic cyst with elevated serum CA 19-9 was reported by Terada et al 6 in 1994. Since then, elevated CA 19-9 serum values have been reported in approximately 30 cases of splenic cysts, most of epithelial origin 7.…”

Section: Discussionmentioning

confidence: 99%

Giant true cyst of the spleen with elevated serum markers, carbohydrate antigen 19-9 and cancer antigen 125

Uludağ

Yetkın²,

Çıtgez³

et al. 2009

Case Reports

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A 19-year-old woman presented with a left upper abdominal mass. Computed tomography of the abdomen showed a solitary cystic lesion in the splenic hilum, approximately 20×16 cm in size, demonstrating almost total displacement of the remaining splenic parenchyma. She had high serum concentrations of carbohydrate antigen 19-9 and cancer antigen 125. A splenectomy was performed. Immunohistochemical study confirmed the existence of an epithelial cyst. Following surgery, the serum concentrations of the tumour markers decreased gradually. True splenic cysts are rare and their origin is controversial. In splenic cysts with high serum concentrations of tumour markers, such as occurred in our patient, cystectomy or splenectomy were preferred to remove tumour marker-producing epithelium and to prevent recurrence after treatment. If the epithelial lining of the cyst cannot be detected under light microscopy, immunohistochemical study should be performed.

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“…Since Walz et al described elevated serum and intracystic CA19-9 and CEA levels in patients with mesothelial splenic cysts, high serum levels of tumor markers, especially CA19-9, have been reported in certain patients with epidermoid cysts. [18][19][20][21] The most likely reason for the high serum levels of CA19-9 is that CA19-9 is secreted from the epithelium on the inner cyst wall, and an increase in the intracystic pressure results in high serum CA19-9 levels. 18 Our patients also had high serum and intracystic levels of CA19-9, and we confirmed positive immunohistochemical staining in the cyst wall by anti-CA19-9, supporting this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Familial Epidermoid Cysts of the Spleen: Report of Two Cases

et al. 2006

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The familial occurrence of epidermoid cysts of the spleen is rare, with only six cases having ever been reported, to our knowledge. We recently diagnosed epidermoid cysts of the spleen in a mother and son. First, a 15-year-old boy was admitted to our hospital for management of blunt abdominal trauma. Computed tomography (CT) showed a ruptured large splenic cyst with an intraabdominal hematoma. We performed a splenectomy, and histopathological examination confirmed the existence of an epidermoid cyst of the spleen. About 2 years and 6 months later, the family physician found that the patient's 41-year-old mother had a large splenic cyst, and she was referred to our hospital for further investigation. CT showed a 10 x 8 cm cyst occupying most of the spleen. The patient underwent splenectomy, and a pathological diagnosis of an epidermoid cyst of the spleen was confirmed. Although the etiology of epidermoid cysts of the spleen is unclear, this familial occurrence may support the hypothesis of congenital malformation as a result of genetic change.

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Carbohydrate Antigen 19–9 Producing Giant Epithelial Cyst of the Spleen in a Young Woman

Cited by 28 publications

References 0 publications

Primary epithelial splenic cyst with micro-rupture and raised carbohydrate antigen CA 19-9: a paradigm of management

Primary epithelial splenic cyst with micro-rupture and raised carbohydrate antigen CA 19-9: a paradigm of management

Giant true cyst of the spleen with elevated serum markers, carbohydrate antigen 19-9 and cancer antigen 125

Familial Epidermoid Cysts of the Spleen: Report of Two Cases

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