Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients

Laurence, V.M.; Ward, R.; Dennis, IF; Bleehen, N. M.

doi:10.1038/bjc.1995.303

Cited by 32 publications

(13 citation statements)

References 29 publications

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“…From a clinical standpoint, it is encouraging that the response to carbogen is observable in a primary tumour model (MNU-induced mammary adenocarcinoma) that arises from a single transformed cell. Significant increases in median pO2, measured by microelectrodes, in response to carbogen have been reported for a range of human tumours (Falk et al, 1992;Laurence et al, 1995) and data on 19 patients indicate that responses of human tumours to carbogen breathing can be satisfactorily monitored by GRE MRI (Taylor et al, 1996). This method may thus become a useful clinical tool in the assessment of patient treatment protocols by monitoring tumour blood flow and oxygenation noninvasively.…”

Section: Discussionmentioning

confidence: 99%

The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imaging

Robinson

Rodrigues²,

Ojugo³

et al. 1997

Br J Cancer

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Summary Gradient-recalled echo magnetic resonance imaging (GRE MRI), which gives information on blood flow and oxygenation changes (Robinson SP, Howe FA, Griffiths JR 1995, Int J Radiat Oncol Biol Phys 33: 855), was used to observe the responses of six rodent tumour models to carbogen breathing. In one transplanted rat tumour, the Morris hepatoma 961 8a, and a chemically induced rat tumour, the MNUinduced mammary adenocarcinoma, there were marked image intensity increases, similar to those previously observed in the rat GH3 prolactinoma. In contrast, the rat Walker carcinosarcoma showed no response. In two mouse tumours, the RIF-1 fibrosarcoma and the human xenograft HT29, carbogen breathing induced a transient fall in signal intensity that reversed spontaneously within a few minutes. The rat GH3 prolactinoma was xenografted into nude mice, and an increase in image intensity was found in response to carbogen, suggesting that any effects that carbogen may have had on the host were not significant determinants of the tumour response. The increases in GRE image intensity of the MNU, H9618a and GH3 tumours during carbogen breathing are consistent with increases in tumour oxygenation and blood flow, whereas the responses of the RIF-1 and HT29 tumours may be the result of a transient steal effect followed by homeostatic correction.

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Section: Discussionmentioning

confidence: 99%

The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imaging

Robinson

Rodrigues²,

Ojugo³

et al. 1997

Br J Cancer

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“…It has been used with or without nicotinamide, which can increase vascular perfusion. The ARCON protocol is currently being evaluated in the clinic and has been demonstrated to increase oxygenation and local control in these patients 94. Nonrandomized clinical studies showed promising results using the ARCON protocol.…”

Section: Treatments To Overcome or Exploit Hypoxiamentioning

confidence: 99%

Hypoxia in head and neck cancer: How much, how important?

Haustermans²,

et al. 2005

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“…The current study was perfonned using one extreme method, BBO, to introduce tumor hyper-oxygenafion. There are other methods, such as using normobaric oxygen/carbogen which may be more clinically applicable, for improving tumor oxygenation (21)(22)(23). The results of the present study warrant further investigation ofthese hyper-oxygenation techniques to improve tumor response to PDT.…”

Section: Discussionmentioning

confidence: 80%

<title>Oxygen effect of photodynamic therapy</title>

Chen

Murphy

et al. 1997

SPIE Proceedings

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Photodynamic therapy (PDT) is rapidly becoming an accepted therapeutic modality for the treatment of some types of malignant tumors. An important feature of PDT is its absolute dependence on molecular oxygen during light irradiation. Hypoxic tumor cells, either pre-existing or photochemically depleted of their oxygen supply during light irradiation, are resistant to PDT treatment, and contribute to treatment failures. We hypothesize that tumor response to PDT can be improved by combining PDT with Hyper-oxygenation, which may simultaneously compensate for the oxygen depletion by PDT and increase oxygenation of the pre-existing hyjoxic cells. The doubling time ofMammary carcinoma (MCa) tumors, implanted in either leg or flank of C3H mice, was evaluated after PDT treatment with/without addition of hyperoxygenation. By adding hyperoxygenation (hyperbaric or normobaric oxygen) to a non-curative PDT dose, a further delay in the tumor regrowth was observed. For a sub-curative dose PDT treatment, the addition of hyperoxygenation resulted in an increase in tumor cure. The results indicate that tumor response can be improved by combining PDT and hyperoxygenation.

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Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients

Cited by 32 publications

References 29 publications

The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imaging

The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imaging

Hypoxia in head and neck cancer: How much, how important?

<title>Oxygen effect of photodynamic therapy</title>

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