Carbofuran pesticide toxicity to the eye

Kempuraj, Duraisamy; Zhang, Eric; Gupta, Suneel; Gupta, Ramesh C.; Sinha, Nishant R.; Mohan, Rajiv R.

doi:10.1016/j.exer.2022.109355

Cited by 10 publications

(3 citation statements)

References 97 publications

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“…Insecticide residues, including carbofuran, in food can pose a threat to non-target organisms [7]. Clinical symptoms of carbofuran poisoning include vomiting, dizziness, muscle weakness, diarrhea, shortness of breath, convulsions, and blurred vision [8]. Bonner et al reported that farmers exposed to carbofuran had a 95% higher risk of lung cancer [9].…”

Section: Introductionmentioning

confidence: 99%

The influence of carbofuran insecticide exposure on the number of type II Lung Cells in Mice (Mus musculus)

Mohammad Vicky Indra Pradicta,

Widjiati Widjiati,

Ratna Damayanti

et al. 2024

Int. J. Biol. Pharm. Sci. Arch.

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The aim of this research was to demonstrate lung histopathological damage in mice (Mus musculus) caused by carbofuran exposure. Twenty female mice (Mus musculus) aged 10 weeks with a body weight of 25-30 g were used in the study. The mice were divided into four groups: P0, P1, P2, and P3. All samples received 0.5 ml/day of physiological NaCl, and P1, P2, and P3 were additionally exposed to carbofuran at doses of 0.0208, 0.0417, and 0.0833 mg/kg body weight of mice/day, respectively. This treatment was carried out for 10 days. Data analysis was performed using ANOVA followed by the BNJ test. The results showed an increase in necrotic type II cells with increasing doses of carbofuran.

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Section: Introductionmentioning

confidence: 99%

The influence of carbofuran insecticide exposure on the number of type II Lung Cells in Mice (Mus musculus)

Mohammad Vicky Indra Pradicta,

Widjiati Widjiati,

Ratna Damayanti

et al. 2024

Int. J. Biol. Pharm. Sci. Arch.

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“…22 Pollutants with different physicochemical properties negatively impact the visual function and performance of distinct organisms. Previous studies reported that heavy metals, 23,24 isoflucypram, 25 triphenyltin, 26 carbofuran, 27 etc., exposed to the environment for a long period could gradually accumulate within the organism and cause severe neurological and retinal cell damage. Considering the crucial role of vision in the survival of organisms and the vulnerability of ocular development to xenobiotics, it is essential to conduct screening studies to understand the detrimental effects and underlying mechanisms of environmental pollutants on visual functions.…”

Section: ■ Introductionmentioning

confidence: 99%

Retinal Degeneration Response to Graphene Quantum Dots: Disruption of the Blood–Retina Barrier Modulated by Surface Modification-Dependent DNA Methylation

Liu,

Tan,

Wang

et al. 2024

Environ. Sci. Technol.

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Graphene quantum dots (GQDs) are used in diverse fields from chemistry-related materials to biomedicines, thus causing their substantial release into the environment. Appropriate visual function is crucial for facilitating the decisionmaking process within the nervous system. Given the direct interaction of eyes with the environment and even nanoparticles, herein, GQDs, sulfonic acid−doped GQDs (S-GQDs), and aminofunctionalized GQDs (A-GQDs) were employed to understand the potential optic neurotoxicity disruption mechanism by GQDs. The negatively charged GQDs and S-GQDs disturbed the response to light stimulation and impaired the structure of the retinal nuclear layer of zebrafish larvae, causing vision disorder and retinal degeneration. Albeit with sublethal concentrations, a considerably reduced expression of the retinal vascular sprouting factor sirt1 through increased DNA methylation damaged the blood−retina barrier. Importantly, the regulatory effect on vision function was influenced by negatively charged GQDs and S-GQDs but not positively charged A-GQDs. Moreover, cluster analysis and computational simulation studies indicated that binding affinities between GQDs and the DNMT1−ligand binding might be the dominant determinant of the vision function response. The previously unknown pathway of blood−retinal barrier interference offers opportunities to investigate the biological consequences of GQD-based nanomaterials, guiding innovation in the industry toward environmental sustainability.

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“…Carbofuran is an inodorous carbamate pesticide that kills insects and nematodes in the crops like soybeans and potatoes. However, it can cause serious damage to human eyes and skin and cause a burning sensation (Kempuraj et al, 2022). On exposure to high temperatures, it releases toxic nitrogen oxides.…”

Section: Introductionmentioning

confidence: 99%

Carbofuran Intoxication in Males, Also Called Cat Killer Pills

Mustafa

Irfan

2023

Biol Clin Sci Res J

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Carbofuran is a frequently used insecticide, acaricide, and nematicide that is used in the field of agriculture all around the world. Presently, carbofuran is commonly used in malicious poisoning. It is among the class of insecticides that are used to eradicate soil-dwelling pests from crops. Approximately 20,000 tonnes of this product is used annually. As effective as it is in controlling insects, it has notorious side effects on humans and is now introduced as "Cat Killer Pills." A 26-year-old male, a healthy student of 12th standard, presented with a suicidal attempt with this 'Cat Killer Pill.' 6 hours after ingestion, he experienced weakness, fatigue, sweating, breathing difficulties, and disorientation. He was initially treated at another hospital, where he was intubated due to a suppressed respiratory system. Upon presentation, he was intubated. He was treated with Atropine and Pralidoxime, which helped in his cure. The results of this study suggest that in addition to the cholinolytic effects of atropine, Pralidoxime may prevent and antagonize the acute toxicity of carbofuran by reactivating cholinesterase and rapid elimination of carbofuran.

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Carbofuran pesticide toxicity to the eye

Cited by 10 publications

References 97 publications

The influence of carbofuran insecticide exposure on the number of type II Lung Cells in Mice (Mus musculus)

The influence of carbofuran insecticide exposure on the number of type II Lung Cells in Mice (Mus musculus)

Retinal Degeneration Response to Graphene Quantum Dots: Disruption of the Blood–Retina Barrier Modulated by Surface Modification-Dependent DNA Methylation

Carbofuran Intoxication in Males, Also Called Cat Killer Pills

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