Carbazoloquinones from Murraya koenigii

A benzoisofuranone derivative and carbazole alkaloids from Murraya koenigii and their antimicrobial activity

“…Traditionally, the plant is used as a stimulant, stomachic, febrifuge, analgesic and for the treatment of diarrhoea, dysentery and insect bites (Kirtikar et al, 1993;Yusuf et al, 1994). Previous phytochemical investigations on this plant revealed the occurrence of carbazole alkaloids (Narasimhan et al, 1968;Chowdhury and Chakraborty, 1971;Chakraborty et al, 1978;Rao et al, 1980;Bhattacharyya et al, 1982;Roy et al, 1982;Fiebig et al, 1985;Bhattacharyya and Chowdhury, 1985;Ito et al, 1993;Reisch et al, 1994;Saha and Chowdhury, 1998;Nutan et al, 1999;Ramsewak et al, 1999;Tachibana et al, 2001;Knolker and Reddy, 2002) and coumarins (Adebajo and Reisch, 2000;Murray et al, 1982). As a part of our research project focussing on Bangladeshi rutaceous species, we here report the isolation of a new benzoisofuranone derivative (10) and a new dimeric carbazole alkaloid (11) together with six known carbazoles and three known steroids from the stem bark of M. koenigii as well as the antimicrobial activities of compounds 1-3 and 6-11.…”

Novel Routes to Pyrroles, Indoles and Carbazoles - Applications in Natural Product Synthesis

“…9) was isolated from the root bark of Murraya euchrestifolia [67] and shows cardiotonic activity [68]. Koeniginequinone A and koeniginequinone B were obtained from the stem bark of Murraya koenigii [69]. The promising pharmacological activity led to a whole series of different total syntheses for murrayaquinone [43d, 43i, 44c], whereas koeniginequinone A and B were prepared in multi-step routes via Fischer-Borsche carbazole synthesis and subsequent oxidation to the carbazole-1,4-quinone [69,70].…”

7-Methoxy-8-Prenylated Coumarins from Murraya koenigii (Linn.) Spreng.

“…4 It has been medicinally important for its antimicrobial, anthelmintic, anti-inflammatory and hypoglecemic properties. 5 Previous phytochemical studies with the alcohol extract of stem bark of M. koenigii provided koenigine-quinone A, koeniginequinone B 6 , 9-carbethoxy-3-methylcarbazole, 9-formyl-3-methylcarbazole 7 , methyl-2-methoxycarbazole-3-carboxylate and 1-hydroxy-3-methyl carbazole. 8 stem bark of M. koenigii.…”