Carbapenem-Susceptible OXA-23-Producing Proteus mirabilis in the French Community

Potron, Anaïs; Hocquet, Didier; Triponney, Pauline; Plésiat, Patrick; Bertrand, Xavier; Valot, Benoı̂t

doi:10.1128/aac.00191-19

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…In addition, as opposed to other Enterobacterales species, the most prevalent carbapenemases reported in Acinetobacter spp. (i.e., OXA-23, OXA-24/40 and OXA-58) have also been reported in P. mirabilis: OXA-23 in France and Finland, OXA-24/40 in Algeria and OXA-58 in Belgium and Germany (4)(5)(6)(7)(8)(9). Recently, a global phylogenetic analysis has demonstrated that a unique clone of P. mirabilis is responsible for the dissemination OXA-23 or OXA-58 carbapenemases in humans and animals since 1996 (10).…”

mentioning

confidence: 75%

High Prevalence of OXA-23 Carbapenemase-Producing Proteus mirabilis among Amoxicillin-Clavulanate-Resistant Isolates in France

Lombès

Bonnin

Laurent

et al. 2022

Antimicrob Agents Chemother

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In this multicentric study performed in 12 French hospitals, we reported that 26.9% (14/52) of the amoxicillin/clavulanate-resistant Proteus mirabilis isolates produced the OXA-23 carbapenemase. We found that inhibition zone diameter less than 11 mm around amoxicillin/clavulanate disc was an accurate screening cut-off to detect these OXA-23 producers. We confirmed by whole genome sequencing that these OXA-23-producers all belonged to the same lineage that has been demonstrated to disseminate OXA-23 or OXA-58 in P. mirabilis .

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mentioning

confidence: 75%

High Prevalence of OXA-23 Carbapenemase-Producing Proteus mirabilis among Amoxicillin-Clavulanate-Resistant Isolates in France

Lombès

Bonnin

Laurent

et al. 2022

Antimicrob Agents Chemother

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“…In study of Bonnet et al (2002) the bla OXA−23 gene was chromosomeencoded, probably resulting from the integration of a plasmid unable to replicate in Enterobacterales. More recently, Österblad et al (2016) in Finland, andPotron et al (2019) in France also described the occurrence of the bla OXA−23 gene in the chromosome of a P. mirabilis isolate with a close genetic environment typical of A. baumannii with insertion sequences ISAba1, ISAba14 and ISAba125. Other resistance genes would have been inserted together with bla OXA−23 such as sul2, floR, strB, and strA (Österblad et al, 2016).…”

Section: Oxa-23mentioning

confidence: 98%

“…Besides the OXA-48 family, which is exclusively found in Enterobacterales and is thus expected to be found in Proteus, other CHDLs such as OXA-23, OXA-40, OXA-58 that have been exclusively identified in Acinetobacter species (Bonnin et al, 2013a) have recently been identified in P. mirabilis (Bonnet et al, 2002;Girlich et al, 2017;Leulmi et al, 2019;Potron et al, 2019).…”

Section: Oxa-48mentioning

confidence: 99%

Genetics of Acquired Antibiotic Resistance Genes in Proteus spp.

2020

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Proteus spp. are commensal Enterobacterales of the human digestive tract. At the same time, P. mirabilis is commonly involved in urinary tract infections (UTI). P. mirabilis is naturally resistant to several antibiotics including colistin and shows reduced susceptibility to imipenem. However higher levels of resistance to imipenem commonly occur in P. mirabilis isolates consecutively to the loss of porins, reduced expression of penicillin binding proteins (PBPs) PBP1a, PBP2, or acquisition of several antibiotic resistance genes, including carbapenemase genes. In addition, resistance to nonβ-lactams is also frequently reported including molecules used for treating UTI infections (e.g., fluoroquinolones, nitrofurans). Emergence and spread of multidrug resistant P. mirabilis isolates, including those producing ESBLs, AmpC cephalosporinases and carbapenemases, are being more and more frequently reported. This review covers Proteus spp. with a focus on the different genetic mechanisms involved in the acquisition of resistance genes to multiple antibiotic classes turning P. mirabilis into a dreadful pandrug resistant bacteria and resulting in difficult to treat infections.

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“…The frequency of OXA-48 production in the United States has been low, with occasional localized isolates reported (248)(249)(250). Interestingly, OXA-23 is often found in P. mirabilis and was the causative pathogen in a cluster of community-onset infections in France (251). However, this provided only low-level resistance to carbapenems in this organism and may go undetected.…”

Section: Carbapenemase-producing Bacteriamentioning

confidence: 99%

Epidemiology of β-Lactamase-Producing Pathogens

Bush

Bradford²

2020

Clin Microbiol Rev

532

440

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SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past 70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases. Although penicillinases in Staphylococcus aureus challenged the initial uses of penicillin, β-lactamases are most important in Gram-negative bacteria, particularly in enteric and nonfermentative pathogens, where collectively they confer resistance to all β-lactam-containing antibiotics. Critical β-lactamases are those enzymes whose genes are encoded on mobile elements that are transferable among species. Major β-lactamase families include plasmid-mediated extended-spectrum β-lactamases (ESBLs), AmpC cephalosporinases, and carbapenemases now appearing globally, with geographic preferences for specific variants. CTX-M enzymes include the most common ESBLs that are prevalent in all areas of the world. In contrast, KPC serine carbapenemases are present more frequently in the Americas, the Mediterranean countries, and China, whereas NDM metallo-β-lactamases are more prevalent in the Indian subcontinent and Eastern Europe. As selective pressure from β-lactam use continues, multiple β-lactamases per organism are increasingly common, including pathogens carrying three different carbapenemase genes. These organisms may be spread throughout health care facilities as well as in the community, warranting close attention to increased infection control measures and stewardship of the β-lactam-containing drugs in an effort to control selection of even more deleterious pathogens.

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Carbapenem-Susceptible OXA-23-Producing Proteus mirabilis in the French Community

Cited by 10 publications

References 18 publications

High Prevalence of OXA-23 Carbapenemase-Producing Proteus mirabilis among Amoxicillin-Clavulanate-Resistant Isolates in France

High Prevalence of OXA-23 Carbapenemase-Producing Proteus mirabilis among Amoxicillin-Clavulanate-Resistant Isolates in France

Genetics of Acquired Antibiotic Resistance Genes in Proteus spp.

Epidemiology of β-Lactamase-Producing Pathogens

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