Carbapenem‐ResistantEscherichia coliHarboringKlebsiella pneumoniaeCarbapenemase β‐Lactamases Associated with Long‐Term Care Facilities

Abstract

Nine carbapenem-resistant Escherichia coli isolates harboring Klebsiella pneumoniae carbapenemase (KPC)-2 or KPC-3 enzymes were identified in patients residing in 7 distinct long-term care facilities. Cefotaxime-hydrolyzing (CTX-M)-type beta-lactamases were also documented in 3 isolates. The identification of these enzymes in patients staying in long-term care facilities should be of great concern to all components of health care systems.

Detection and Characterization of <i>β</i>-Lactamase Encoding Genes in Carbapenem Non-Susceptible Gram-Negative Bacteria and Susceptibility of Isolates to Ceftazidime-Avibactam at a New York City Community Hospital

“…In this surveillance study designed to identify current β-lactamases in a New York City hospital, KPC β-lactamases were the predominant enzymes characterized in carbapenem non-susceptible Enterobacteriaceae and reinforces our previously published studies recognizing such enzymes in hospitalized and community patients and in residents of our associated LTCF [6] Klebsiella pneumoniae (13) 64 Check MDR microarray systems or other commercially available systems. These enzymes are not inhibited by any current β-lactamase inhibitors, including avibactam.…”

Carbapenemases in Klebsiella pneumoniae and Other Enterobacteriaceae: an Evolving Crisis of Global Dimensions

“…Outbreaks of KPC-producing E. coli have occurred in health care facilities in various countries, including the United States, Israel, and Greece (29,105,160,249). Also, sporadic KPC-positive isolates of a wide variety of other enterobacterial species have been described worldwide (Table 1) (166,191).…”

Susceptibility Profiles, Molecular Epidemiology, and Detection of KPC-Producing Escherichia coli Isolates from the New York City Vicinity

“…(16,20). The spread of bla KPC to Escherichia coli is particularly worrisome, and reports of these isolates from the United States and Israel have surfaced (2,12,14,19). A propensity for these pathogens to be recovered from residents of long-term-care facilities has been noted (2,12,14,19).…”

“…Isolates of E. coli from Queens were screened with meropenem disk diffusion testing; nonsusceptible isolates were also tested for the presence of bla KPC . Some of the isolates from Brooklyn and Queens have been included in prior reports (2,19). Isolates from Connecticut were referred to the Research Laboratory in Brooklyn because of their relatively high MICs to carbapenems.…”