Carbapenem-resistant Enterobacteriaceae in pediatric bloodstream infections in rural Southern India

Sekar, Ramalingam; Mythreyee, Manoharan; Srivani, Seetharaman; Sivakumaran, Dharmaraj; Lallitha, Sivathanu; Saranya, Selvam

doi:10.1007/s13312-017-1204-1

Cited by 20 publications

(15 citation statements)

References 10 publications

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“…The class A carbapenemase in KPC in paediatric hospital isolated in the USA and UK [10,11,14]. And class B including NDM, IMP and VIM has been described in India, USA and Spain respectively [3,8,18]. A outbreak of OXA-48 (class D) begun in 2012 (16 cases in NICU and 1 in PICU) confirmed that all the microorganisms isolated from children belonged to the same strain (ST11) [19].…”

Section: Discussionmentioning

confidence: 86%

“…In the past decade, carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat and begun to spread worldwide [1,2]. CRE have been sporadically reported in Asia in recent years [3]. Carbapenem antibiotics have been used as the most effective drugs for the treatment of these severe infections.…”

Section: Introductionmentioning

confidence: 99%

“…However, with the widespread use of imipenem and meropenem, CRE is increasing year by year. Due to the multiple drug resistance mechanisms produced by CRE, the selection of antimicrobial agents for the treatment of CRE infection poses great challenges [1,3,4]. A study on CRE infection showed that CRE can cause many serious infections, such as pneumonia, intra-abdominal infections, urinary tract infections, and device-related infections.…”

Section: Introductionmentioning

confidence: 99%

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The characteristics of antimicrobial resistance and treatment of carbapenem-resistant Enterobacteriaceae infections in children from 2013 to 2018 in a chinese tertiary hospital

Jia¹,

Pan²,

Luo³

et al. 2019

Preprint

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Background The aim of this study was to performe a retrospective analysis of prevalence and treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections in children in a tertiary hospital. Methods The non-repeat clinical isolates of CRE in children were collected in Liaocheng People's Hospital from January, 2013 to December, 2018. The bacterial identification and antibiotic susceptibility was performed according to the standard methods. The isolated strains will be detected carbapenemases genotypes and homology analysis. All data on the culture-positive strains and associated clinical infection from different pediatric wards were reviewed. Results A total of 20 CRE strains isolated from pediatric patients, which derived from different infection sites and present a classification of multiple species of Enterobacteriaceae. And the production of IMP-type carbapenemase in these strains is the main reason of antimicrobial resistance. Most of the infected patients have severe comorbidities and invasive procedures, and use insensitive drugs due to the high resistance rates and medication restrictions. Nevertheless, most infected children have been treated despite the resistance of pathogens to multiple antimicrobial agents. In our follow-up survey, most children received adjuvant therapy such as human intravenous immunoglobulin, which may be an important factor in helping patients defeat pathogenic bacteria. Conclusions This study demonstrates a high prevalence of IMP-mediated CRE infection in pediatric patients with severe comorbidities and invasive procedures. Most children have been cured, which may be related to application of adjuvant therapy and weaker pathogenicity of the IMP-type Enterobacteriaceae.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The characteristics of antimicrobial resistance and treatment of carbapenem-resistant Enterobacteriaceae infections in children from 2013 to 2018 in a chinese tertiary hospital

Jia¹,

Pan²,

Luo³

et al. 2019

Preprint

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“…5,12 There are few reports on prevalence of CRE in rural population from India. One study from rural southern India reported 22.1% of CRE in isolates from hospitalized children with blood stream infections, 13 while another study from the same rural population on hospitalized patients reported a prevalence of carbapenemase-producing E. coli and K. pneumoniae among all categories of infections, i.e.,19.4%. 6 However, in the later study, resistance to ertapenem was detected by disc diffusion method only in contrast to our study where detection rate of CRE was based on positivity by both MHT and MIC.…”

Section: Discussionmentioning

confidence: 99%

Carbapenemase and NDM-1 Production by Escherichia coli and Klebsiella pneumoniae from Patients belonging to a Rural Community in North India Hospitalized with CommunityAcquired Infections

Chattopadhya¹

2018

JCD

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Carbapenem-resistant Enterobacteriaceae, especially New Delhi metallo-β-lactamase type-1-producing strains, exhibit multidrug resistance, thus posing a serious public health threat for treatment of infections caused by Gram-negative bacteria. However, most of the studies on the problem have been confined to hospitalized patients from urban population. The present study was carried out to detect carbapenemase production among Escherichia coli and Klebsiella pneumoniae Isolated from rural population hospitalized with community acquired infections. A total of 296 non-repetitive isolates of E. coli and K. pneumoniae were subjected to Modified Hodge test for carbapenemase detection, Metallo-β-lactamase detection by MIC test strip MBL and molecular detection of bla NDM gene by Polymerase Chain Reaction (PCR). Twenty three (7.8%) of the 296 isolates were detected as carbapenemase producers, of which five (21.7%) were found to harbor bla NDM genes by PCR. Gene sequencing of all the five isolates revealed bla NDM-1 genes. The present study showed the prevalence of carbapenemase-producing E. coli and K. pneumoniae in the rural community of North India and spread of NDM-1.

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“…Patients from countries where CRO are endemic (e.g., India, Turkey, or Egypt) (11)(12)(13)(14)25) may introduce CRO into pediatric institutions in countries where they are not endemic, suggesting the need for specific interventions, such as screening for colonization and specific empirical antimicrobial treatment in patients from these countries newly admitted with infectious diseases (36,40,42).…”

Section: Risk Factors For Infection or Colonizationmentioning

confidence: 99%

Carbapenem-Resistant Gram-Negative Bacterial Infections in Children

Aguilera‐Alonso

Escosa-García

Saavedra-Lozano

et al. 2020

Antimicrob Agents Chemother

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Carbapenem-resistant organisms (CRO) are a major global public health threat. Enterobacterales hydrolyze almost all β-lactams through carbapenemase production. Infections caused by CRO are challenging to treat due to the limited number of antimicrobial options. This leads to significant morbidity and mortality. Over the last few years, several new antibiotics effective against CRO have been approved. Some of them (e.g., plazomicin or imipenem-cilastatin-relebactam) are currently approved for use only by adults; others (e.g., ceftazidime-avibactam) have recently been approved for use by children. Recommendations for antibiotic therapy of CRO infections in pediatric patients are based on evidence mainly from adult studies. The availability of pediatric pharmacokinetic and safety data is the cornerstone to broaden the use of proposed agents in adults to the pediatric population. This article provides a comprehensive review of the current knowledge regarding infections caused by CRO with a focus on children, which includes epidemiology, risk factors, outcomes, and antimicrobial therapy management, with particular attention being given to new antibiotics.

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Carbapenem-resistant Enterobacteriaceae in pediatric bloodstream infections in rural Southern India

Cited by 20 publications

References 10 publications

The characteristics of antimicrobial resistance and treatment of carbapenem-resistant Enterobacteriaceae infections in children from 2013 to 2018 in a chinese tertiary hospital

The characteristics of antimicrobial resistance and treatment of carbapenem-resistant Enterobacteriaceae infections in children from 2013 to 2018 in a chinese tertiary hospital

Carbapenemase and NDM-1 Production by Escherichia coli and Klebsiella pneumoniae from Patients belonging to a Rural Community in North India Hospitalized with CommunityAcquired Infections

Carbapenem-Resistant Gram-Negative Bacterial Infections in Children

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