Carbapenem-resistant Acinetobacter baumannii in patients with burn injury: A systematic review and meta-analysis

Lima, William Gustavo; Alves, Geisa Cristina Silva; Sanches, Cristina; Fernandes, Simone Odília Antunes; Paiva, Magna Cristina de

doi:10.1016/j.burns.2019.07.006

Cited by 46 publications

(30 citation statements)

References 57 publications

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“…Additional reports described KPC-3 in A. baumannii a Portugese University hospital [138], and both KPC-2 and KPC-3 in isolates from Brazil [139]. In a recent meta-analysis about A. baumannii in burn injury patients, the prevalence of KPC was over 16% [140]. Carriers of a KPC variants are usually MDR microorganism, and standard medical treatment becomes ineffective with high mortality rates [139].…”

Section: Ambler Class a Enzymesmentioning

confidence: 99%

Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen

2020

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Being a multidrug-resistant and an invasive pathogen, Acinetobacter baumannii is one of the major causes of nosocomial infections in the current healthcare system. It has been recognized as an agent of pneumonia, septicemia, meningitis, urinary tract and wound infections, and is associated with high mortality. Pathogenesis in A. baumannii infections is an outcome of multiple virulence factors, including porins, capsules, and cell wall lipopolysaccharide, enzymes, biofilm production, motility, and iron-acquisition systems, among others. Such virulence factors help the organism to resist stressful environmental conditions and enable development of severe infections. Parallel to increased prevalence of infections caused by A. baumannii, challenging and diverse resistance mechanisms in this pathogen are well recognized, with major classes of antibiotics becoming minimally effective. Through a wide array of antibiotic-hydrolyzing enzymes, efflux pump changes, impermeability, and antibiotic target mutations, A. baumannii models a unique ability to maintain a multidrug-resistant phenotype, further complicating treatment. Understanding mechanisms behind diseases, virulence, and resistance acquisition are central to infectious disease knowledge about A. baumannii. The aims of this review are to highlight infections and disease-producing factors in A. baumannii and to touch base on mechanisms of resistance to various antibiotic classes.

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Section: Ambler Class a Enzymesmentioning

confidence: 99%

Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen

2020

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“…Once the A. baumannii is found in a hospital surroundings, there is a serious amount of health risk for vulnerable, chronically ill patients in ICU wards since most of them are immunocompromised and stay in the hospital for an extended period of time (Howard et al 2012). Acinetobacter baumannii is responsible for a number of diseases such as pneumonia (especially VAP), osteomyelitis, peritonitis, endocarditis, septicaemia, meningitis, and wound, skin, soft tissue, urinary tract, ear and eye infections (Joshi et al 2006;Lima et al 2019).…”

Section: Nosocomial Infectionsmentioning

confidence: 99%

“…For these reasons, they are usually prescribed as antibiotics of last resort for critically ill patients. In recent years, Acinetobacter species have become a significant cause of critical healthcare-associated diseases and infections (Lima et al 2019). Acinetobacter baumannii is predominantly related to hospital-acquired infections globally and is an aerobic Gram-negative pathogen that leads to infections of the skin, bloodstream, urinary tract and other soft tissues (Joshi and Litake 2013;Lin and Lan 2014;Lee et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Carbapenem resistance in Acinetobacter baumannii , and their importance in hospital‐acquired infections: a scientific review

2021

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Carbapenem is an important therapy for serious hospital-acquired infections and for the care of patients affected by multidrug-resistant organisms, specifically Acinetobacter baumannii; however, with the global increase of carbapenem-resistant A. baumannii, this pathogen has significantly threatened public health. Thus, there is a pressing need to better understand this pathogen in order to develop novel treatments and control strategies for dealing with A. baumannii. In this review, we discuss an overview of carbapenem, including its discovery, development, classification and biological characteristics, and its importance in hospital medicine especially in critical care units. We also describe the peculiarity of bacterial pathogen, A. baumannii, including its commonly reported virulence factors, environmental persistence and carbapenem resistance mechanisms. In closing, we discuss various control strategies for overcoming carbapenem resistance in hospitals and for limiting outbreaks. With the appearance of strains that resist carbapenem, the aim of this review is to highlight the importance of understanding this increasingly problematic healthcare-associated pathogen that creates significant concern in the field of nosocomial infections and overall public health. Carbapenem Development and history of carbapenemSafe and effective antibiotics play an important role in medical care and their development remains one of the

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“…As reported previously, it has been observed that A. baumannii is transmitted primarily by contact or invasive procedures, such as surgery, mechanical respirator or tracheostomy [6,21]. It has been also described that burned patients are particularly susceptible to an Acinetobacter infection during hospitalization [22]. All patients enrolled in this study underwent an invasive procedure and/or were immunocompromised.…”

Section: Discussionmentioning

confidence: 59%

Nosocomial transmission of extensively drug resistant Acinetobacter baumannii strains in a tertiary level hospital

et al. 2020

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Acinetobacter baumannii is an opportunistic infectious agent that affects primarily immunocompromised individuals. A. baumannii is highly prevalent in hospital settings being commonly associated with nosocomial transmission and drug resistance. Here, we report the identification and genetic characterization of A. baumannii strains among patients in a tertiary level hospital in Mexico. Whole genome sequencing analysis was performed to establish their genetic relationship and drug resistance mutations profile. Ten genetically different, extensively drug resistant strains were identified circulating among seven wards. The genetic profiles showed resistance primarily against aminoglycosides and beta-lactam antibiotics. Importantly, no mutants conferring resistance to colistin were observed. The results highlight the importance of implementing robust classification schemes for advanced genetic characterization of A. baumannii clinical isolates and simultaneous detection of drug resistance markers for adequate patient's management in clinical settings.

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Carbapenem-resistant Acinetobacter baumannii in patients with burn injury: A systematic review and meta-analysis

Cited by 46 publications

References 57 publications

Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen

Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen

Carbapenem resistance in Acinetobacter baumannii , and their importance in hospital‐acquired infections: a scientific review

Nosocomial transmission of extensively drug resistant Acinetobacter baumannii strains in a tertiary level hospital

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