Carbapenem non-susceptibility of Klebsiella pneumoniae isolates in hospitals from 2011 to 2016, data from the German Antimicrobial Resistance Surveillance (ARS)

Koppe, Uwe; Laer, Anja von; Kroll, Lars Eric; Noll, Ines; Feig, Marcel; Schneider, Marc; Claus, H.; Eckmanns, Tim; Sin, Muna Abu

doi:10.1186/s13756-018-0362-9

Cited by 30 publications

(32 citation statements)

References 25 publications

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“…Increasing resistance to antibiotics is one of the main problems within present medicine. The rapid spread of CPE, including those with MBLs, has become a critical challenge of infection control and treatment [8]. The first carbapenemaseproducing bacteria were identified in 1991 in Japan [9].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the usefulness of selected methods for the detection of carbapenemases in Klebsiella strains

Sękowska

Bogiel

Kaczmarek

2020

Journal of Medical Microbiology

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Introduction. Klebsiella rods, belonging to the family Enterobacteriaceae , are generally opportunistic pathogens commonly associated with nosocomial infections, especially in intensive care units. Interestingly, strains of this genus also show multi-drug resistance. In recent years, multiple studies have indicated that the prevalence of carbapenem resistance has increased rapidly among Klebsiella representatives. Aim. The aim of this study was to assess the usefulness of selected phenotypic and genotypic methods for the detection of the most important carbapenemases in Klebsiella strains. Methodology. The study involved 51 Klebsiella strains. The ability to produce carbapenemases was determined by phenotypic methods (double disc synergy test, test with four discs and three inhibitors, CarbaNP test, culture on chromogenic medium, panels of automatic method – Phoenix, CIM test and modified Hodge test). The potential for carbapenemase synthesis was also evaluated using real-time PCR, detecting bla VIM/IMP, bla KPC, bla NDM and bla OXA-48 genes. Results. Using the phenotypic methods, positive results were obtained for all of the analysed strains. Using PCR, carbapenemase synthesis potential was confirmed on the molecular level; the bla VIM gene was detected in 23 strains, the bla NDM gene in 26 strains and the bla OXA-48 gene in two strains. Conclusion. There was complete agreement between the carbapenemases detected by the genetic method and the results obtained with phenotypic methods.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the usefulness of selected methods for the detection of carbapenemases in Klebsiella strains

Sękowska

Bogiel

Kaczmarek

2020

Journal of Medical Microbiology

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“…Uwe Koppe et al [20] reported the number of KP isolates tested non-susceptible to 3 carbapenems (imipenem, meropenem, and ertapenem). In our study, we explored the changing trends of KP isolates resistance to 1, 2, and 3 carbapenems.…”

Section: Discussionmentioning

confidence: 99%

The epidemiology, risk factors and outcomes of Carbapenem-resistant Klebsiella pneumoniae infections in the intensive care unit from 2012 to 2018

Wang

Zou

Zhou

et al. 2020

Preprint

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Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing globally threat for human health, but the trends and clinical characteristics of CRKP infections in the intensive care unit(ICU) remain uninvestigated.Methods: A retrospective study was conducted among ICU patients infected with KP isolates from January 2012 to December 2018. Carbapenem resistant to Klebsiella pneumoniae was defined according to Clinical and Laboratory Standards Institute (CLSI) criteria. The incidence and changing trend of CRKP were determined. CRKP patient sources, specimen types, infection sources and outcomes were investigated. Results: There were 256(40.13%) patients with CRKP and 382(59.87%) patients with CSKP. The incidence of CRKP increased from 2012(11.11%) to 2017(63.48%) and decreased in 2018(51.52%). The proportion of isolates not susceptible to three carbapenems increased from 0 to 98.04%. The rates of CRKP isolated from blood, wound, urine and pleural fluid were higher than that of CSKP. CRKP infections were mainly ICU acquired, rather than input acquired. Conclusion: The incidence of CRKP was high in ICU, but showed a downward trend. Implementation of different infection control measures to different sources of patients, specimen types, and KP infections are necessary. Surveillance data will be needed for ICU patients to decrease the incidence and mortality of CRKP.

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“…Monitoring data from the German Antimicrobial Resistance Surveillance (ARS) show that the isolation rate of K. pneumoniae, which was not sensitive to carbapenems, in Germany in 2011-2016 was only 0.63%. [17] In addition, K. pneumoniae, which was not sensitive to carbapenems, was often resistant to other antibiotics, such as gentamicin, Sulfanilamide and tegacyclin.…”

Section: Discussionmentioning

confidence: 99%

Bacterial etiology of lower respiratory tract infection:a surveillance report from a Chinese large teaching hospital from 2015 to 2019

Zhang

Tian

2020

Preprint

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Background Sputum is the most common specimen type of lower respiratory tract in China, but its cultivation result is easily confused by the bacteria colonized in the oral cavity and pharynx. It is very difficult to evaluate the clinical significance of sputum culture results both for clinicians and microbiologists. Bronchoscope alveolus lavage fluid(BALF)is a good specimen, which can accurately reflect the situation of lower respiratory tract infections (LRIs). Methods The accumulated data of BALF culture and antimicrobial susceptibility test in our hospital from January 2015 to October 2019 were reviewed and analyzed. Results The positive rate of BALF culture in our hospital was 18.3% (3467/18935) in 2015–2019. The most common pathogens were Klebsiella pneumoniae (18.1%, 627/3467), Pseudomonas aeruginosa (16.9%, 587/3467) and Acinetobacter baumannii (14.0%, 485/3467). For the eight most common pathogens, 40–70 years old was the highest age of distribution, but for Escherichia coli and Streptococcus pneumoniae, 0–5 years old was also the higher age of distribution. The antibiotic resistance rate of K. pneumoniae to imipenem and meropenem was 30.6% and 30.8%, respectively. The sensitivity of P. aeruginosa to antibiotics other than minocycline and ticarcillin clavulanic acid was all more than 60%. However, the resistance rate of A. baumannii to antibiotics other than tegacyclin and minocycline was all more than 80%. Conclusions 40–70 years old was the high incidence age of lower respiratory tract bacterial infection. K. pneumoniae resistant to carbapenems (CR-K. pneumoniae) and A. baumannii were a great challenge to clinical treatment and bacterial resistance control.

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Carbapenem non-susceptibility of Klebsiella pneumoniae isolates in hospitals from 2011 to 2016, data from the German Antimicrobial Resistance Surveillance (ARS)

Cited by 30 publications

References 25 publications

Evaluation of the usefulness of selected methods for the detection of carbapenemases in Klebsiella strains

Evaluation of the usefulness of selected methods for the detection of carbapenemases in Klebsiella strains

The epidemiology, risk factors and outcomes of Carbapenem-resistant Klebsiella pneumoniae infections in the intensive care unit from 2012 to 2018

Bacterial etiology of lower respiratory tract infection:a surveillance report from a Chinese large teaching hospital from 2015 to 2019

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