Carbamoylmannose enhances the tumor targeting ability of supramolecular nanoparticles formed through host–guest complexation of a pair of homopolymers

Yao, Xikuang; Zhu, Qiwen; Li, Cheng; Yuan, Kangjun; Che, Rui; Zhang, Peng; Yang, Chengli; Lü, Wei; Wu, Wei; Jiang, Xiqun

doi:10.1039/c6tb02863b

Cited by 17 publications

(10 citation statements)

References 43 publications

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“…[177][178][179][180] Furthermore, stimulus-responsive β-CD-based nanoplatforms have also been described as promising candidates for developing a variety of practical theranostics by combining tumour judgement and handling to detect therapeutic drug biodistribution and recognize imaging-guided chemotherapy. [181][182][183][184] 6.7. Wastewater Applications Synthesize β-CD based NPs to offer an ecofriendly platform for the selective removal of organic compounds typically present in wastewater, industrialized misuse water and pharmaceutical residues in particular in municipal wastewater.…”

Section: β-Cd Based Nanoplatforms For Cancer Treatmentmentioning

confidence: 99%

β‐Cyclodextrin‐Based Nanocomposite Derivatives: State of the Art in Synthesis, Characterization and Application in Molecular Recognition

Tarannum

Kumar

2022

ChemistrySelect

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This review describes the synthesis of nanocomposite derivatives based on β‐cyclodextrin (β‐CD) using silver nanoparticles (NPs), gold NPs, magnetic NPs, carbon nanotubes, nanosheets, carbon dots and graphene oxide NPs. These nanocomposites were prepared by green synthesis method, chemical method, reduction method, thermal reduction, ultrasonication method and hydrothermal method. β‐CD is cyclic oligosaccharide consisting of seven glucose units linked by 1,4‐α‐glycosidic bonds. Its external surface is hydrophilic due to the substantial hydroxyl groups, and the interior is hydrophobic. β‐CD are useful in nanocomposites and metallic NPs because they provide nanoplatforms for biocompatibility. β‐CD is commonly used to change NPs because of their excellent biocompatibility, amphipathic properties and for enhancing the morphological and chemical features of nanocomposites. Thus, nanostructured materials based on β‐CD may enhance the potential for molecular recognition property which is a natural phenomenon and fundamentally important in chemistry and biology. The most important area in molecular recognition research is design and synthesis of model receptors (hosts) to recognize substrates (guests) of biochemical significance to mimic biological events. Because NPs have a high surface‐to‐volume ratio when combined with molecularly imprinted polymers (MIPs). This review briefs the application and characterizations of β‐CD based nanocomposites derivatives in molecular recognition.

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Section: β-Cd Based Nanoplatforms For Cancer Treatmentmentioning

confidence: 99%

β‐Cyclodextrin‐Based Nanocomposite Derivatives: State of the Art in Synthesis, Characterization and Application in Molecular Recognition

Tarannum

Kumar

2022

ChemistrySelect

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“…Electrostatic complexes of the amphiphilic polyelectrolytes, cationic polysuccinimide with secondary hydrophobic amine groups and anionic sodium polyaspartate, showed an increased ability to encapsulate curcumin, rapid cell internalization and reduced cytotoxicity in comparison to the individual polyelectrolytes [76]. Incorporation of carbamoylmannose in polyelectrolyte NPs illustrated specific uptake from cancer cells through receptor-mediated endocytosis [77]. Interestingly, this bleomycin monosaccharide was loaded on NPs formed by host-guest interactions between β-cyclodextrin-terminated poly(N-vinylpyrrolidone) and adamantyl-ended poly(aspartic acid).…”

Section: Self-assembled Nanoformulationsmentioning

confidence: 99%

Current Research on Polyelectrolyte Nanostructures: From Molecular Interactions to Biomedical Applications

Papagiannopoulos¹

2021

Macromol

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Polyelectrolytes have been at the center of interdisciplinary research for many decades. In the field of polymer science and soft matter, they have provided the dimensions of electrostatic interactions, which opens a vast variety of opportunities for new physical properties and applications. In biological matter, polyelectrolytes are present in many forms, from extracellular polysaccharides to complex DNA molecules and proteins. This review discusses the recent research on polyelectrolytes covering the fundamental level of their conformations and nanostructures, their molecular interactions with materials that have close relevance to bioapplications and their applications in the biomedical field. This approach is motivated by the fact that the polyelectrolyte research is constantly active in all the aforementioned levels and continually affects many critical scientific areas.

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“…Four kinds of inhibitors were employed: NaN 3 , which is a kind of adenosine 5′-triphosphate (ATP)-dependent endocytosis inhibitor; CPZ, which is a clathrin-mediated endocytosis inhibitor; methyl-β-cyclodextrin, which is a caveolae-mediated endocytosis inhibitor; and cytochalasin B, which inhibits micropinocytosis. 50,51 The CPP vesicles were added into the A549 cells at 37°C for 4 h after the cells were pretreated with various inhibitors. As shown in Supporting Information Figure S9, even in the presence of various endocytosis inhibitors, CPP vesicles could be efficiently internalized by cells, indicating that the inhibitors had no significant effect on the process of cellular internalization of CPP vesicles.…”

Section: Cell Internalization Of Cpp Assembliesmentioning

confidence: 99%

Self-Assembly of Crystalline Vesicles from Nonplanar π-Conjugated Nanocycles

Tang

Qiao

et al. 2021

CCS Chem

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There is a great demand for self-assembled carbon nanomaterials because of their importance in optoelectronics, biomaterials, and so forth. Herein, we report a novel type of self-assembled, nanoscale, crystalline vesicle from nonplanar π-conjugated nanocycles. We designed four different structural [8]cycloparaphenylenes ([8]CPPs) molecules and demonstrated that these nonplanar π-conjugated CPP nanocycles could self-assemble into multilamellar, crystalline vesicles in tetrahydrofuran (THF)/H 2 O mixed solvent. The critical driving force for the assembly of nanoscale CPP vesicles is crystallization and π-π interaction of nonplanar, nanocyclic molecules. The size of CPP vesicles could be regulated by changing water content, temperature, and concentration in solution. Our data demonstrate that these π-conjugated nanocycle-based vesicles show a remarkable ability to enter cells in an energy-or temperature-independent manner and kill cancer cells. When the side groups of the CPP molecule were changed, the CPP vesicles showed a large difference in the cytotoxicity, and two CPP vesicles could effectively kill cancer cells as well as first-class antitumor agents.

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Carbamoylmannose enhances the tumor targeting ability of supramolecular nanoparticles formed through host–guest complexation of a pair of homopolymers

Abstract: Bleomycin monosaccharide-decorated platinum-incorporating supramolecular nanoparticles showed excellent tumor targeting and antitumor efficacy.

Cited by 17 publications

References 43 publications

β‐Cyclodextrin‐Based Nanocomposite Derivatives: State of the Art in Synthesis, Characterization and Application in Molecular Recognition

β‐Cyclodextrin‐Based Nanocomposite Derivatives: State of the Art in Synthesis, Characterization and Application in Molecular Recognition

Current Research on Polyelectrolyte Nanostructures: From Molecular Interactions to Biomedical Applications

Self-Assembly of Crystalline Vesicles from Nonplanar π-Conjugated Nanocycles

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